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prevalence of antibodies to 3 retroviruses in a captive colony of macaque monkeys.the prevalence of antibodies to 3 retroviruses in the macaque colony of the new england regional primate research center (nerprc) was determined using enzyme-linked immunosorbent assay procedures as well as radioimmunoprecipitation-sds polyacrylamide gel electrophoresis and indirect immunofluorescence tests. out of 848 macaques, 3 (0.35%) had antibodies to simian immunodeficiency virus (siv), 27 (3.2%) had antibodies to simian t-lymphotropic virus type i (stlv-1) and approximately 285 (34%) had ...19882895751
spontaneous renal lymphosarcoma in a juvenile cynomolgus monkey (macaca fascicularis).spontaneous lymphosarcoma, likely of renal origin, was diagnosed in a naive, juvenile, male cynomolgus monkey (macaca fascicularis). histologically, renal architecture was effaced by dense infiltrating sheets of plump cells with indistinct borders and scant amphophilic cytoplasm. mitoses were uncommon. similar neoplastic infiltrates were also present in the right renal cortex, one adrenal medulla, the prostate, seminal vesicles, myocardium, and the pulmonary interstitium. serological tests were ...19947932641
prevalence of enzootic simian viruses among urban performance monkeys in indonesia.animal reservoirs are the most important sources of emerging infectious diseases that threaten human populations. global travel and tourism bring ever-increasing numbers of humans into contact with animals, increasing the likelihood of cross species transmission of infectious agents. non-human primates come into contact with humans in a variety of contexts and may harbor infectious agents with zoonotic potential. we investigated the prevalence of infection with enzootic simian viruses among 20 u ...200516359412
establishment of specific pathogen-free macaque colonies in tsukuba primate research center of japan for aids research.cynomolgus monkeys have been maintained in indoor facilities as closed colony monkeys in tsukuba primate research center in japan since 1978. several microorganisms, including bacteria, parasites and viruses, were eliminated from the cynomolgus monkeys in this colony of tprc. various kinds of viruses (b virus, measles virus, simian varicella virus, simian immunodeficiency virus, simian t cell leukemia virus, simian d type retrovirus, simian cytomegalovirus, simian epstein-barr virus, and simian ...201020510748
severe acquired idiopathic thrombocytopenia in a female cynomolgus macaque (macaca fascicularis).a 4-y-old female cynomolgus macaque presented for veterinary evaluation prior to placement in a preclinical study showed markedly low platelet counts that continued to decrease over time. physical examination over the next several days showed areas of pale red discoloration in forelimbs, anterior thorax, and inguinal area and multifocal pinpoint areas of erythema or scabs. an area of dark red discoloration approximately 2 cm in diameter on the dorsal surface of the tongue was discovered on day 9 ...201526141452
transmission of stlv in a closed colony of macaques.a 3.3% seroprevalence of simian t-lymphotropic virus (stlv) was found in a closed breeding and research colony of rhesus and cynomolgus macaques in thailand. epidemiology of stlv within the colony was assessed by means of a retrospective analysis of banked and freshly collected serum samples, and a review of the animals' medical records. evidence was found that the virus had been imported into the colony by some of the original animals, and was subsequently transmitted both vertically and horizo ...200415195332
establishment of primate lymphoblastic cell lines by coculture with a simian t-cell leukemia virus-1 positive, hypoxanthine-guanine-phosphoribosyltransferase negative japanese macaque cell line.a cell line (jamh17+) resistant to 8-azaguanine was established from a human t-cell leukemia virus type 1 related virus (simian t-cell leukemia virus-1) positive japanese macaque cell line. lymphoblastic cell lines were established from the peripheral blood mononuclear cells of humans, hominoids, and several species of macaques by coculture with jamh17+ in hypoxanthine-aminopterin-thymidine medium. htlv-1 specific antigen was detected in some of the established cell lines. phenotypic analysis sh ...19882835483
low rates of transmission of srv-2 and stlv-i to juveniles in a population of macaca fascicularis facilitate establishment of specific retrovirus-free colonies.prevalence of simian retrovirus-2 (srv-2) and simian t lymphotropic virus type i (stlv-i), was unknown in 337 captive cynomolgus macaques.200919320800
simian t-cell lymphotropic virus type i alters the proviral load and biodistribution of simian retrovirus type 2 in co-infected macaques, supporting advancement of immunosuppressive pathology.the infection dynamics and pathology of a retrovirus may be altered by one or more additional viruses. to investigate this further, this study characterized proviral load, biodistribution and the immune response in macaca fascicularis naturally infected with combinations of simian retrovirus type 2 (srv-2) and simian t-cell lymphotropic virus type i (stlv-i). as the mesenteric lymph node (mln) and the spleen have been implicated previously in response to retroviral infection, the morphology and ...201323197576
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