[a great franco-mauritian epidemiologist: joseph désiré tholozan (1820-18970].born in 1820 from french parents in diego garcia, an islet then linked to mauritius where he started in port-louis his school years, joseph désiré tholozan was an original personality. he undertook medical studies in france (m. d. thesis, paris, 1843) after having joined the military health service (1841) as a surgeon serving in various garrisons in the country and later at the hospital of the valde-grâce in paris (1849). successful at the "agrégation" of medicine in 1853, he later participated ...19989559181
[joseph désiré tholozan and the persian relapsing fever].in the year 1879, tholozan seems to have been convinced of the danger caused by the bites of ornithodores in persia, as a result of very careful observations of sick persons suffering from iranian relapsing fever due to borrelia persica. among the ticks collected by him and sent to entomologists in france was the true vector, named argas (presently ornithodoros) tholozani by laboulbene and megnin. tholozan's contribution to our knowledge on persian relapsing fever is really important. he was one ...199811625357
the epidemiology of tick-borne relapsing fever in iran during 1997-2006.tick-borne relapsing fever is an acute febrile and endemic disease in iran. for many reasons, the incidence of disease is on decrease, however tick-borne relapsing fever is still a health issue in the rural areas for travelers. this study was carried out during 1997-2006 to investigate the tick-borne relapsing fever in iran.200919411042
borrelia persica infection in dogs and cats: clinical manifestations, clinicopathological findings and genetic characterization.relapsing fever (rf) is an acute infectious disease caused by arthropod-borne spirochetes of the genus borrelia. the disease is characterized by recurrent episodes of fever that concur with spirochetemia. the rf borrelioses include louse-borne rf caused by borrelia recurrentis and tick-borne endemic rf transmitted by argasid soft ticks and caused by several borrelia spp. such as b. crocidurae, b. coriaceae, b. duttoni, b. hermsii, b. hispanica and b. persica. human infection with b. persica is t ...201627160515
borrelia persica: in vitro cultivation and characterization via conventional pcr and multilocus sequence analysis of two strains isolated from a cat and ticks from israel.borrelia persica, one of the pathogenic agents of tick-borne relapsing fever, is transmitted by the soft tick ornithodoros tholozani. it causes infections in humans as well as in animals. in this study, we developed a medium, termed pettenkofer/lmu bp, for reliable in vitro cultivation. cell densities up to 5.2×10(7) viable cells/ml were achieved over at least 40 passages. the cultivable b. persica strain isolated from a cat was further analyzed by amplification of the flab gene using convention ...201526169028
a case of canine borreliosis in iran caused by borrelia persica.tick-borne relapsing fever is an endemic disease in iran, with most cases attributed to infection by borrelia persica, which is transmitted by ornithodoros tholozani soft ticks. here, we report spirochetemia in blood of a puppy residing in tehran, iran. the causative species was identified by use of highly discriminative igs sequencing; the 489 bp igs sequence obtained in our study showed 99% identity (100% coverage) when compared with b. persica sequences derived from clinical cases or from o. ...201626776536
borrelia persica infection in immunocompetent mice--a new tool to study the infection kinetics in vivo.borrelia persica, a bacterium transmitted by the soft tick ornithodoros tholozani, causes tick-borne relapsing fever in humans in the middle east, central asia and the indian peninsula. immunocompetent c3h/heouj mice were infected intradermally with b. persica at varying doses: 1 x 10(6), 1 x 10(4), 1 x 10(2) and 4 x 10(0) spirochetes/mouse. subsequently, blood samples were collected and screened for the presence of b. persica dna. spirochetes were detected in all mice infected with 1 x 10(6), 1 ...201626890814
detection of borrelia persica infection in ornithodoros tholozani using pcr targeting rrs gene and xenodiagnosis.relapsing fever caused by borrelia persica, is an acute tick-borne disease which is transmitted by soft ticks of ornithodoros tholozani to human.201123113113
molecular characterization of borrelia persica, the agent of tick borne relapsing fever in israel and the palestinian authority.the identification of the tick borne relapsing fever (tbrf) agent in israel and the palestinian authority relies on the morphology and the association of borrelia persica with its vector ornithodoros tholozani. molecular based data on b. persica are very scarce as the organism is still non-cultivable. in this study, we were able to sequence three complete 16s rrna genes, 12 partial flab genes, 18 partial glpq genes, 16 rrs-ilet intergenic spacers (igs) from nine ticks and ten human blood samples ...201021124792
relapsing fever borreliosis in eurasia--forgotten, but certainly not gone!tick-borne relapsing fever (tbrf) has been reported in eurasia and attributed mainly to borrelia persica, although other entities have also been described. ornithodoros tholozani is the most important tick vector, found in india and kashmir, the southern countries of the former ussr, iran, iraq, syria, jordan, turkey, israel, egypt, and cyprus. it inhabits caves, ruins, and burrows of rodents and small mammals. in the northern countries, o. tholozani also lives in houses and cowsheds. in israel, ...200919489923
postexposure treatment with doxycycline for the prevention of tick-borne relapsing fever.tick-borne relapsing fever (tbrf) is an acute febrile illness. in israel, tbrf is caused by borrelia persica and is transmitted by ornithodoros tholozani ticks. we examined the safety and efficacy of postexposure treatment to prevent tbrf.200616837678
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