Publications

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lessons from the nipah virus outbreak in malaysia.the nipah virus outbreak in malaysia (september 1998 to may 1999) resulted in 265 cases of acute encephalitis with 105 deaths, and near collapse of the billion-dollar pig-farming industry. because it was initially attributed to japanese encephalitis, early control measures were ineffective, and the outbreak spread to other parts of malaysia and nearby singapore. the isolation of the novel aetiological agent, the nipah virus (niv), from the cerebrospinal fluid of an outbreak victim was the turnin ...200719108397
generation of tioman virus nucleocapsid-like particles in yeast saccharomyces cerevisiae.tioman virus (tiov) was isolated from a number of pooled urine samples of tioman island flying foxes (pteropus hypomelanus) during the search for the reservoir host of nipah virus. studies have established tiov as a new virus in the family paramyxoviridae. this novel paramyxovirus is antigenically related to menangle virus that was isolated in australia in 1997 during disease outbreak in pigs. tiov causes mild disease in pigs and has a predilection for lymphoid tissues. recent serosurvey showed ...200919559738
nipah virus encephalitis outbreak in malaysia.emerging infectious diseases involving zoonosis have become important global health problems. the 1998 outbreak of severe febrile encephalitis among pig farmers in malaysia caused by a newly emergent paramyxovirus, nipah virus, is a good example. this disease has the potential to spread to other countries through infected animals and can cause considerable economic loss. the clinical presentation includes segmental myoclonus, areflexia, hypertension, and tachycardia, and histologic evidence incl ...200211938496
tioman virus, a novel paramyxovirus isolated from fruit bats in malaysia.a search for the natural host of nipah virus has led to the isolation of a previously unknown member of the family paramyxoviridae. tioman virus (tiv) was isolated from the urine of fruit bats (pteropus hypomelanus) found on the island of the same name off the eastern coast of peninsular malaysia. an electron microscopic study of tiv-infected cells revealed spherical and pleomorphic-enveloped viral particles (100--500 nm in size) with a single fringe of embedded peplomers. virus morphogenesis oc ...200111336547
isolation of nipah virus from malaysian island flying-foxes.in late 1998, nipah virus emerged in peninsular malaysia and caused fatal disease in domestic pigs and humans and substantial economic loss to the local pig industry. surveillance of wildlife species during the outbreak showed neutralizing antibodies to nipah virus mainly in island flying-foxes (pteropus hypomelanus) and malayan flying-foxes (pteropus vampyrus) but no virus reactive with anti-nipah virus antibodies was isolated. we adopted a novel approach of collecting urine from these island f ...200211880045
full length genome sequence of tioman virus, a novel paramyxovirus in the genus rubulavirus isolated from fruit bats in malaysia.a novel paramyxovirus in the genus rubulavirus, named tioman virus (tiv), was isolated in 1999 from a number of pooled urine samples of island flying foxes (pteropus hypomelanus) during the search for the reservoir host of nipah virus. tiv is antigenically related to menangle virus (menv) that was isolated in australia in 1997 during disease outbreak in pigs. sequence analysis of the full length genome indicated that tiv is a novel member of the genus rubulavirus within the subfamily paramyxovir ...200212111411
molecular characterization of nipah virus from pteropus hypomelanus in southern thailand.nipah virus (niv) first emerged in malaysia in 1998, with two bat species (pteropus hypomelanus and p. vampyrus) as the putative natural reservoirs. in 2002, niv igg antibodies were detected in these species from thailand, but viral rna could not be detected for strain characterization. two strains of niv (malaysia and bangladesh) have been found in p. lylei in central thailand, although bangladesh strain, the causative strain for the outbreak in bangladesh since 2001, was dominant. to understan ...201627016237
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