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molecular cloning and functional characterization of eleven subtypes of interferon-α in amur tigers (panthera tigris altaica).interferon has a broad-spectrum of antiviral effects and represents an ideal choice for the development of antiviral drugs. nonetheless, information about alpha interferon (ifn-α) is vacant in amur tiger (panthera tigris altaica), an endangered species and indigenous to northeast asia. herein, 11 ptifn-αs genes, which encoded proteins of 164-165 amino acids, were amplified. afterwards, expression and purification were conducted in escherichia coli. in physicochemical analysis, ptifn-αs were show ...201728751224
outbreak and genotyping of canine distemper virus in captive siberian tigers and red pandas.in this study, four canine distemper virus (cdv) strains were isolated from captive siberian tigers (panthera tigris altaica) and red pandas (ailurus fulgens) during two separate cdv outbreaks in a zoo in guangdong province, china. sequence alignment and phylogenetic analyses based on the full-length hemagglutinin (h) and fusion (f) genes showed that they were closely identical to genotype asia-1. prior to confirmation of cdv in siberian tigers, to control spread of the disease, a live attenuate ...201728811626
morbillivirus infection in a wild siberian tiger in the russian far east.we report the first documented case of morbillivirus infection in a wild, free-ranging siberian tiger (panthera tigris altaica). the tigress entered a small village in the russian far east in an ambulatory but stuporous state with no apparent recognition or fear of humans. her condition progressed rapidly with neurological signs, anorexia, and ultimately death. histologic lesions included vacuolated to malacic white matter in the brain stem, cerebellum, and thalamus, with associated lymphocytic ...201020966275
canine distemper virus: an emerging disease in wild endangered amur tigers (panthera tigris altaica).fewer than 500 amur tigers (panthera tigris altaica) remain in the wild. due to low numbers and their solitary and reclusive nature, tiger sightings across their range in the russian far east and china are rare; sightings of sick tigers are rarer still. serious neurologic disease observed in several wild tigers since 2001 suggested disease emergence in this endangered species. to investigate this possibility, histology, immunohistochemistry (ihc), in situ hybridization (ish), and reverse transcr ...201323943758
canine distemper virus (cdv) in another big cat: should cdv be renamed carnivore distemper virus?one of the greatest threats to the conservation of wild cat populations may be dogs or, at least, one of their viruses. canine distemper virus (cdv), a single-stranded rna virus in the paramyxoviridae family and genus morbillivirus, infects and causes disease in a variety of species, not just canids. an outbreak of cdv in wild lions in the serengeti, tanzania, in 1994 was a wake-up call for conservationists, as it demonstrated that an infectious disease could swiftly impact a previously healthy ...201324045642
estimating the potential impact of canine distemper virus on the amur tiger population (panthera tigris altaica) in russia.lethal infections with canine distemper virus (cdv) have recently been diagnosed in amur tigers (panthera tigris altaica), but long-term implications for the population are unknown. this study evaluates the potential impact of cdv on a key tiger population in sikhote-alin biosphere zapovednik (sabz), and assesses how cdv might influence the extinction potential of other tiger populations of varying sizes. an individual-based stochastic, sird (susceptible-infected-recovered/dead) model was used t ...201425354196
serosurvey of free-ranging amur tigers in the russian far east.wild amur tigers (panthera tigris altaica, n=44) from the russian far east were tested for antibodies to feline leukemia virus, feline corona virus (fcov), feline immunodeficiency virus, feline parvovirus (fpv), canine distemper virus (cdv), toxoplasma gondii, and bartonella henselae. antibodies to fcov, cdv, fpv, and t. gondii were detected in 43, 15, 68, and 42% of tigers, respectively. no differences were detected in antibody prevalence estimates between tigers captured as part of a research ...201222247389
canine distemper virus as a threat to wild tigers in russia and across their range.canine distemper virus (cdv) has recently been identified in populations of wild tigers in russia and india. tiger populations are generally too small to maintain cdv for long periods, but are at risk of infections arising from more abundant susceptible hosts that constitute a reservoir of infection. because cdv is an additive mortality factor, it could represent a significant threat to small, isolated tiger populations. in russia, cdv was associated with the deaths of tigers in 2004 and 2010, a ...201525939829
mortality of amur tigers: the more things change, the more they stay the same.poaching as well as loss of habitat and prey are identified as causes of tiger population declines. although some studies have examined habitat requirements and prey availability, few studies have quantified cause-specific mortality of tigers. we used cumulative incidence functions (cifs) to quantify cause-specific mortality rates of tigers, expanding and refining earlier studies to assess the potential impact of a newly emerging disease. to quantify changes in tiger mortality over time, we re-e ...201526096683
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