pathogenesis of tularemia in monkeys aerogenically exposed to francisella tularensis 425.the pathogenesis of tularemia was studied in groups of rhesus monkeys (macaca mulatta) that inhaled graded 10-fold doses ranging from 10 through 10(6) organisms of francisella tularensis 425, a strain highly virulent for the white mouse but of reduced virulence for the domestic rabbit. mean incubation periods ranged from 3 to 6 days followed by acute illness lasting 5 to 11 days with subsequent recovery of most animals. the higher inhaled doses resulted in shorter incubation periods, longer and ...19724629251
infraspecific taxonomy of tularemia agent francisella tularensis mccoy et chapin.the authors investigated 286 strains of the tularemia microbe isolated in a number of countries of the old and the new world from humans, hares, rodents, ticks, water and other objects, including 217 strains from the ussr and 69 strains from other countries. as a result, the earlier observed subspecific differences in the biological properties of the tularemia strains isolated in different regions were reconfirmed on an extensive material. it is proposed to designate the three subspecies disting ...19827142690
first isolation of francisella tularensis subsp. tularensis in europe.francisella tularensis subsp. tularensis is the common causal agent of tularemia in the usa and canada, while f. tularensis subsp. palaearctica (holarctica) occurs in europe, asia, and to a minor extent in north america. f. tularensis subsp. mediaasiatica was found only in central asia in a part of the former soviet union. of the total of 155 f. tularensis strains isolated over the years 1978-1996 during the surveillance of tularemia in slovakia, 65 were from small mammals, 68 from ticks and 22 ...19989928875
evolutionary insights into il17a in leporids, il17a had been implicated in the host defense against extracellular pathogens, such as francisella tularensis that infects hares and rabbits and causes the zoonotic disease tularemia. here, we studied il17a from five lagomorphs, european rabbit, pygmy rabbit, brush rabbit, european brown hare, and american pika. we observed that this protein is highly conserved between these species, with a similarity of 97-99% in leporids and ~88% between leporids and american pika. the exon/intron ...201526788019
spatio-temporal dynamics of tularemia in french wildlife: 2002-2013.tularemia, caused by francisella tularensis, is endemic in france. the surveillance of this disease in wildlife is operated by the sagir network and by the national reference laboratory for tularemia. wild animals found dead or dying collected by the sagir network are necropsied and when tularemia is suspected culture and/or pcr are performed to confirm the diagnosis. the aim of this study was to present the results of tularemia surveillance in wildlife and to investigate the spatial and tempora ...201627435644
francisella species in ticks and animals, iberian peninsula.the presence of francisella species in 2134 ticks, 93 lagomorphs and 280 small mammals from the iberian peninsula was studied. overall, 19 ticks and 6 lagomorphs were positive for francisella tularensis subsp. holarctica, suggesting, as described for other regions, that lagomorphs may have an important role in the maintenance of f. tularensis in nature. of the 6 positive lagomorphs, 4 were identified as the european rabbit, oryctogalus cuniculus. additionally, 353 ticks and 3 small mammals were ...201626520052
comparison of bacterial culture and polymerase chain reaction (pcr) for the detection of f. tularensis subsp. holarctica in wild animals.detection of the zoonotic pathogen francisella tularensis subsp. holarctica (ef tularensis) in wild animals with culture techniques as well as polymerase chain reaction were compared and discussed on the basis of the investigation of 60 animals. the samples originated from 55 european brown hares (lepus europaeus), two red foxes (vulpes vulpes) and one each from a wild rabbit (oryctolagus cuniculus), a european beaver (castor fiber), and a lemur (lemur catta). when comparing the growth of 28 f. ...201323901583
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