characterization of a canine homolog of hepatitis c estimated 3% of the world's population is chronically infected with hepatitis c virus (hcv). although hcv was discovered more than 20 y ago, its origin remains obscure largely because no closely related animal virus homolog has been identified; furthermore, efforts to understand hcv pathogenesis have been hampered by the absence of animal models other than chimpanzees for human disease. here we report the identification in domestic dogs of a nonprimate hepacivirus. comparative phylogenetic an ...201121610165
canine hepacivirus ns3 serine protease can cleave the human adaptor proteins mavs and trif.canine hepacivirus (chv) was recently identified in domestic dogs and horses. the finding that chv is genetically the virus most closely related to hepatitis c virus (hcv) has raised the question of whether hcv might have evolved as the result of close contact between dogs and/or horses and humans. the aim of this study was to investigate whether the ns3/4a serine protease of chv specifically cleaves human mitochondrial antiviral signaling protein (mavs) and toll-il-1 receptor domain-containing ...201222870331
serology-enabled discovery of genetically diverse hepaciviruses in a new host.genetic and biological characterization of new hepaciviruses infecting animals contributes to our understanding of the ultimate origins of hepatitis c virus (hcv) infection in humans and dramatically enhances our ability to study its pathogenesis using tractable animal models. animal homologs of hcv include a recently discovered canine hepacivirus (chv) and gb virus b (gbv-b), both viruses with largely undetermined natural host ranges. here we used a versatile serology-based approach to determin ...201222491452
nonprimate hepaciviruses in domestic horses, united kingdom.although the origin of hepatitis c virus infections in humans remains undetermined, a close homolog of this virus, termed canine hepacivirus (chv) and found in respiratory secretions of dogs, provides evidence for a wider distribution of hepaciviruses in mammals. we determined frequencies of active infection among dogs and other mammals in the united kingdom. samples from dogs (46 respiratory, 99 plasma, 45 autopsy samples) were chv negative by pcr. screening of 362 samples from cats, horses, do ...023171728
molecular surveillance of traditional and emerging pathogens associated with canine infectious respiratory disease.a molecular survey for traditional and emerging pathogens associated with canine infectious respiratory disease (cird) was conducted in italy between 2011 and 2013 on a total of 138 dogs, including 78 early acute clinically ill cird animals, 22 non-clinical but exposed to clinically ill cird dogs and 38 cird convalescent dogs. the results showed that canine parainfluenza virus (cpiv) was the most commonly detected cird pathogen, followed by canine respiratory coronavirus (crcov), bordetella bron ...201627527760
new and emerging pathogens in canine infectious respiratory disease.canine infectious respiratory disease is a common, worldwide disease syndrome of multifactorial etiology. this review presents a summary of 6 viruses (canine respiratory coronavirus, canine pneumovirus, canine influenza virus, pantropic canine coronavirus, canine bocavirus, and canine hepacivirus) and 2 bacteria (streptococcus zooepidemicus and mycoplasma cynos) that have been associated with respiratory disease in dogs. for some pathogens a causal role is clear, whereas for others, ongoing rese ...201424232191
canine hepacivirus and idiopathic hepatitis in dogs from a dutch cohort.liver diseases are highly prevalent in the general dog population, though the etiology is often unknown. recently a homolog of human hepatitis c virus was discovered in dogs with respiratory infections. although this canine hepacivirus (chv) was detectable in some liver samples, a clear link with liver disease has not been established. a recent study by bexfield et al. showed that in a large cohort of dogs from the uk with idiopathic hepatitis, no evidence can be found for exposure to, or carrie ...201424903449
canine hepacivirus is not associated with chronic liver disease in dogs.canine hepacivirus (chv) has recently been identified in liver and respiratory tract samples from dogs, and comparative phylogenetic analysis has confirmed it to be the closest genetic relative of hepatitis c virus (hcv) described to date. chv offers great potential as a model system for hcv, but only if the underlying processes of infection and pathogenesis are similar for both viruses. however, it is not yet clear if chv is hepatotrophic. canine chronic hepatitis (ch) is a common and usually i ...201424438684
detection of non-primate hepaciviruses in uk dogs.non-primate hepacivirus (nphv) has been identified in dogs, horses, bats and wild rodents. the presence of nphv in dogs outside of the usa however is yet to be established. here we describe for the first time the detection of nphv in the uk dog population (described throughout the manuscript as cnnphv). we examined tissues collected from dogs housed in a rehoming kennel where respiratory disease was endemic. cnnphv rna was detected in the tracheal tissues of 48/210 dogs by rt-pcr, and in the liv ...201526086431
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