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in vitro and in vivo activities of a triterpenoid saponin extract (px-6518) from the plant maesa balansae against visceral leishmania species.the in vitro and in vivo activities of a mixture of six oleane triterpene saponins, recovered from the methanolic extract of the leaves of the vietnamese plant maesa balansae (px-6518), were evaluated against drug-sensitive visceral leishmania strains. the in vitro 50% inhibitory concentration (ic(50)) against intracellular leishmania infantum amastigotes was 0.04 micro g/ml. the cytotoxic concentrations causing 50% cell death (cc(50)s) were about 1 micro g/ml in murine macrophage host cells and ...200414693530
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