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in vitro antiplasmodial, antileishmanial and antitrypanosomal activities of selected medicinal plants used in the traditional arabian peninsular region.worldwide particularly in developing countries, a large proportion of the population is at risk for tropical parasitic diseases. several medicinal plants are still used traditionally against protozoal infections in yemen and saudi arabia. thus the present study investigated the in vitro antiprotozoal activity of twenty-five plants collected from the arabian peninsula.201222520595
study of the in vitro antiplasmodial, antileishmanial and antitrypanosomal activities of medicinal plants from saudi arabia.the present study investigated the in vitro antiprotozoal activity of sixteen selected medicinal plants. plant materials were extracted with methanol and screened in vitro against erythrocytic schizonts of plasmodium falciparum, intracellular amastigotes of leishmania infantum and trypanosoma cruzi and free trypomastigotes of t. brucei. cytotoxic activity was determined against mrc-5 cells to assess selectivity. the criterion for activity was an ic₅₀ < 10 μg/ml (<5 μg/ml for t. brucei) and a sel ...201223011279
in vitro activities of plant extracts from saudi arabia against malaria, leishmaniasis, sleeping sickness and chagas disease.the in vitro activity of the methanol extracts of 51 plants randomly collected from the kingdom of saudi arabia and some of their fractions (petroleum ether, chloroform, ethyl acetate and aqueous) were evaluated against plasmodium falciparum, trypanosoma brucei brucei, t. cruzi and leishmania infantum, as well as toxicity against mrc-5 fibroblast cells. ten crude methanolic extracts that demonstrated potent and adequately selective antiprotozoal activity were subjected to solvent fractionation u ...201020127723
in vitro antiprotozoal activity of triterpenoid constituents of kleinia odora growing in saudi arabia.two lupane and four ursane triterpenes, namely epilupeol (1), lupeol acetate (2), ursolic acid (3), brein (4), 3β 11α-dihydroxy urs-12-ene (5) and ursolic acid lactone (6) were isolated from aerial parts of kleinia odora and identified. compounds 1 and 3-6 were isolated for the first time from k. odora. the triterpene constituents were investigated for antiprotozoal potential against erythrocytic schizonts of plasmodium falciparum, intracellular amastigotes of leishmania infantum and trypanosoma ...201323912274
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