multilocus microsatellite typing (mlmt) of strains from turkey and cyprus reveals a novel monophyletic l. donovani sensu lato foci of human cl caused by strains of the leishmania donovani (l. donovani) complex have been recently described in cyprus and the çukurova region in turkey (l. infantum) situated 150 km north of cyprus. cypriot strains were typed by multilocus enzyme electrophoresis (mlee) using the montpellier (mon) system as l. donovani zymodeme mon-37. however, multilocus microsatellite typing (mlmt) has shown that this zymodeme is paraphyletic; composed of distantly related genetic subgroups of differen ...201222348162
genomic confirmation of hybridisation and recent inbreeding in a vector-isolated leishmania population.although asexual reproduction via clonal propagation has been proposed as the principal reproductive mechanism across parasitic protozoa of the leishmania genus, sexual recombination has long been suspected, based on hybrid marker profiles detected in field isolates from different geographical locations. the recent experimental demonstration of a sexual cycle in leishmania within sand flies has confirmed the occurrence of hybridisation, but knowledge of the parasite life cycle in the wild still ...201424453988
in vitro antiprotozoal activity of extracts of five turkish lamiaceae species.the in vitro antiprotozoal activities of crude methanolic extracts from the aerial parts of five lamiaceae plants (salvia tomentosa, s. sclarea, s. dichroantha, nepeta nuda subsp. nuda and marrubium astracanicum subsp. macrodon) were evaluated against four parasitic protozoa, i.e. trypanosoma brucei rhodesiense, t. cruzi, leishmania donovani and plasmodium falciparum. the cytotoxic potentials of the extracts on l6 cells were also evaluated. melarsoprol, benznidazole, miltefosine, chloroquine and ...201122224291
turkish freshwater and marine macrophyte extracts show in vitro antiprotozoal activity and inhibit fabi, a key enzyme of plasmodium falciparum fatty acid biosynthesis.the ethanolic extracts of a number of turkish freshwater macrophytes (potamogeton perfoliatus, ranunculus tricophyllus and cladophora glomerata) and marine macroalgae (dictyota dichotoma, halopteris scoparia, posidonia oceanica, scinaia furcellata, sargassum natans and ulva lactuca) were assayed for their in vitro antiprotozoal activity. trypanosoma brucei rhodesiense, trypanosoma cruzi, leishmania donovani and plasmodium falciparum were used as test organisms. the cytotoxicity of the extracts w ...200616697632
visceral leishmaniasis and pseudomonas septicemia associated with hemophagocytic syndrome and myelodysplasia in a turkish 18-month-old boy presented with fever, hepatosplenomegaly, jaundice, pancytopenia, hyperferritinemia, hypertriglyceridemia and evidence of hemophagocytosis and trilineage myelodysplasia in the bone marrow aspiration. appropriate treatment was begun but he died after 12 hours of hospitalization due to gram-negative septicemia. post-mortem examination of liver biopsy revealed diffuse hemaphagocytic lymphohistiocytosis and leishmania-donovani bodies in macrophages.200516052865
evaluation of antiprotozoal and plasmodial enoyl-acp reductase inhibition potential of turkish medicinal plants.a total of 58 extracts of different polarity were prepared from various organs of 16 species of turkish plants and screened for their antitrypanosomal, antileishmanial and antiplasmodial activities. no significant activity was observed against trypanosoma cruzi, whereas many extracts showed appreciable trypanocidal potential against t. brucei rhodesiense, with the chcl(3)-soluble portion of phlomis kurdica being the most active (ic(50) 2.7 microg[sol ]ml). almost all extracts, particularly the c ...200515852483
[sporadic kala-azar in the black sea region].visceral leishmaniasis is a disease, also called kala-azar, caused by species of leishmania, which is known as intracellular parasite. disease show a broad spectrum on the clinical symptoms. this infection is seen classically in mediterranean countries, in same asian countries between 30th-48th north parallels and in south america. in mediterranean countries the parasite causing the visceral leishmaniasis is leishmania donovani. turkey is also a mediterranean country taking place between 36th-42 ...19902287295
the emergence of leishmania major and leishmania donovani in southern southern turkey, leishmania tropica and l. infantum are both the causative agents of cutaneous leishmaniasis (cl) and visceral leishmaniasis (vl), respectively. however, l. major and l. donovani were known to exist after the influx of syrian refugees.201424449479
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