Publications

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leishmania infantum: sequence homology within minicircle classes regardless of geographical distance. 19957498439
short report: leishmania tropica: etiologic agent of a case of canine visceral leishmaniasis in northern morocco.the domestic dog has been previously demonstrated to be the reservoir of leishmania infantum, the etiologic agent of human visceral leishmaniasis around the mediterranean basin. it can also be infected with l. tropica, the etiologic agent of anthroponotic cutaneous leishmaniasis in morocco. we report a canine l. tropica visceral infection for the first time in morocco.19979288811
morphological and isoenzymatic differentiation of sympatric populations of phlebotomus perniciosus and phlebotomus longicuspis (diptera: psychodidae) in northern morocco.the phlebotomine sandfly phlebotomus perniciosus newstead is a vector of leishmania infantum nicolle in the western mediterranean basin. in northern morocco it is often caught in sympatry with a closely related species, p. longicuspis nitzulescu. in the locality of chefchaouene where females of both species were morphologically distinguishable, none of the collected males exhibited forked copulatory valves, which is considered a specific character for p. perniciosus. they 1st were identified as ...199910071503
sandflies of the phlebotomus perniciosus complex: mitochondrial introgression and a new sibling species of p. longicuspis in the moroccan rif.the bloodsucking adult females of phlebotomus perniciosus newstead and p. longicuspis nitzulescu (diptera: psychodidae) are important vectors of the protozoan leishmania infantum nicolle (kinetoplastida: trypanosomatidae) in western mediterranean countries. the species status of the two phlebotomine sandflies was assessed, along with the epidemiological implications. individual sandflies from three moroccan rif populations were characterized morphologically, isoenzymatically (by the isoelectrofo ...200415009443
first detection and genetic typing of leishmania infantum mon-24 in a dog from the moroccan mediterranean coast: genetic diversity of mon-24.as in the countries edging the mediterranean basin, leishmania infantum zymodeme mon-1 is the main causative agent of visceral leishmaniasis in morocco, where visceral leishmaniasis is most active in the north-eastern slopes of the rif mountains. the dog was confirmed to be the main reservoir of l. infantum mon-1, while the reservoir of l. infantum mon-24 causative agent of both infantile visceral leishmaniasis and cutaneous leishmaniasis has not yet been identified. here we report the first det ...200717603990
[human leishmaniases in morocco: a nosogeographical diversity.]leishmaniases in morocco are endemic diseases. three forms of leishmaniasis are reported, visceral leishmaniasis, cutaneous leishmaniasis caused by leishmania tropica and cutaneous lesions due to leishmania major. leishmania infantum, a common parasite inducing visceral leishmaniasis, was observed thereafter in cutaneous lesions. the first case of cutaneous leishmaniasis due to l. tropica was isolated since 1987. but, this parasite was shown to be more polymorphic with almost 8 zymodemes. howeve ...200919942371
successful treatment of imported mucosal leishmania infantum leishmaniasis with miltefosine after severe hypokalemia under meglumine antimoniate treatment.old world mucosal leishmaniasis is a rare but regularly reported disease in southern europe. we report the case of a 64-year-old woman who developed severe hypokalemia under meglumine antimoniate treatment and was successfully treated under second line therapy with miltefosine.201122414039
a variant in the promoter of mbl2 is associated with protection against visceral leishmaniasis in morocco.progressive visceral leishmaniasis (vl) is fatal if not treated; yet, most infections with the causative agents are asymptomatic. we hypothesized that genetic factors contribute to this variable response to infection. the mannose-binding lectin 2 gene (mbl2) is a candidate that merits examination in the context of vl because it enhances infection with intracellular pathogens. four functional mbl2 polymorphisms at codons 52, 54, 57 and in the promoter at the -221 position (x/y) are known to be as ...201322995279
moroccan leishmania infantum: genetic diversity and population structure as revealed by multi-locus microsatellite typing.leishmania infantum causes visceral and cutaneous leishmaniasis in northern morocco. it predominantly affects children under 5 years with incidence of 150 cases/year. genetic variability and population structure have been investigated for 33 strains isolated from infected dogs and humans in morocco. a multilocus microsatellite typing (mlmt) approach was used in which a mlmtype based on size variation in 14 independent microsatellite markers was compiled for each strain. mlmt profiles of 10 tunis ...201324147078
molecular detection and identification of leishmania infection in naturally infected sand flies in a focus of cutaneous leishmaniasis in northern morocco.cutaneous leishmaniasis is an infectious disease caused by various species of the flagellate protozoan leishmania. during the past 20 years, cutaneous leishmaniasis has emerged as a major public health threat in morocco. the main objective of this study was to study the occurrence of leishmania infection in vectors and to identify sand fly blood meal sources in an endemic locality of cutaneous leishmaniasis within sefrou province, where the vectors of leishmaniasis were still unknown.201424990497
[a boy with an unexpected souvenir from morocco].a 12-year-old boy returned from a summer holiday in north morocco with a slowly progressive erythematous, infiltrated plaque with a central crust on his right cheek. we diagnosed this as cutaneous leishmaniasis. treatment for leishmania major infection failed; subsequent pcr species typing revealed leishmania infantum. this case shows the importance of recognition of parasitic skin diseases in travellers to the nearby subtropics and the value of leishmania species typing.201425227885
the current status of cutaneous leishmaniasis in morocco.cutaneous leishmaniasis (cl) is a public health problem on a global level because it affects the population of 88 countries. in morocco, it is widely distributed, caused by leishmania tropica, leishmania major and leishmania infantum rarely. the geographical distribution of different forms of leishmaniasis in morocco is linked to well described bioclimatic zones. over the past two decades, the epidemiological situation of cl has changed significantly. it acquire an increasingly epidemic status w ...201424659693
coexistence of leishmania tropica and leishmania infantum in sefrou province, morocco.cutaneous leishmaniasis (cl) has been recently emerged in new foci, posing a public health problem. increasing cases of cl have been reported during recent years in sefrou province, a previously non-endemic area. the present study was designed for epidemiological and parasitological characterization of the disease for the first time in this area. the results of a retrospective analysis of cl cases reports, between 2000 and 2011 showed that the incidence was estimated to 463/100,000 inhabitants/y ...201424161534
slc11a1 polymorphisms and susceptibility to visceral leishmaniasis in moroccan patients.human visceral leishmaniasis is endemic in the mediterranean basin. since most infections are sub-clinical or asymptomatic, host genetics can provide concrete evidence in determining disease outcome. slc11a1/nramp1 is a candidate gene that may be related to host susceptibility versus resistance to intracellular pathogens. this study aimed to determine possible association of slc11a1 polymorphisms with visceral leishmaniasis among moroccan children. a total of 106 children who developed visceral ...201425151047
species composition of phlebotomine sand fly fauna in an area with sporadic cases of leishmania infantum human visceral leishmaniasis, morocco.visceral and cutaneous leishmaniases are the main endemic vector-born diseases in morocco. human visceral leishmaniasis (hvl), by leishmania infantum, currently presents a significant health problem throughout the country and may constitute factor for death, especially among children with less than 15 years old. in the past, hvl has been basically absent or at least sporadic in marrakesh-tensift-al haouz region; however it became significant during the last decade. an entomological survey and a ...201525930188
visceral leishmaniasis due to leishmania infantum in a kidney transplant recipient living in france. 201525487142
ecological and epidemiological status of species of the phlebotomus perniciosus complex (diptera: psychodidae, phlebotominae) in morocco.leishmania infantum (kinetoplastida: trypanosomatidae) infection is transmitted by an infected female sand fly (diptera: psychodidae, phlebotominae) of the subgenus larroussius: phlebotomus ariasi, phlebotomus perniciosus, and phlebotomus longicuspis in the mediterranean basin. in morocco, the vectorial role of p. ariasi was demonstrated, while that of p. longicuspis and p. perniciosus is not elucidated. in addition, moroccan p. longicuspis and p. perniciosus populations present a higher morphol ...201626593735
the tlr2 and tlr4 gene polymorphisms in moroccan visceral leishmaniasis patients.visceral leishmaniasis (vl) is endemic in the mediterranean basin and leads to the most severe form of leishmania infection, lethal if left untreated. however, most infections are sub-clinical or asymptomatic, reflecting the influence of host genetic background on disease outcome. this study aimed to investigate possible association of tlr4 asp299gly, tlr4 thr399ile and tlr2 arg753gln polymorphisms with vl in moroccan children. we enrolled 119 children with vl caused by leishmania infantum as we ...201626943993
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