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in vitro susceptibility to antimonials and amphotericin b of leishmania infantum strains isolated from dogs in a region lacking drug selection pressure.the aim of this study was to evaluate the susceptibility to anti-leishmanial agents of 24 strains isolated from dogs living in the urban area of alger lacking drug selection pressure. two different leishmania infantum zymodemes, mon-1 and mon-281, were identified in these dogs. the in vitro susceptibility to the main forms of antimonial and amphotericin were assessed on promastigote and amastigote life stages in culture. the results obtained for both parasite life stages were concordant whatever ...201222349936
first detection of leishmania infantum dna in phlebotomus longicuspis nitzulescu, 1930 from visceral leishmaniasis endemic focus in algeria.two clinico-epidemiological forms of leishmaniasis caused by leishmania infantum complex are endemic in algeria: human visceral leishmaniasis (hvl) and sporadic cutaneous leishmaniasis. in the northern part of the country, the kabylian region is the main endemic hvl focus with more than 200 cases recorded annually. during the summer of 2009, an entomological study was performed in larbaa nath irathen with the aim to identify the vectors of leishmania and of phleboviruses. in the present paper, w ...201222350715
[leishmania infantum mon-1 isolated from phlebotomus perniciosus, in kabylia (algeria)]. 19902080833
cutaneous leishmaniasis caused by leishmania killicki, algeria. 201424565368
heterogeneity of molecular resistance patterns in antimony-resistant field isolates of leishmania species from the western mediterranean area.antimonials remain the first-line treatment for the various manifestations of leishmaniasis in most areas where the disease is endemic, and increasing cases of therapeutic failure associated with parasite resistance have been reported. in this study, we assessed the molecular status of 47 clinical isolates of leishmania causing visceral and cutaneous leishmaniasis from algeria, tunisia, and southern france. in total, we examined 14 genes that have been shown to exhibit significant variations in ...201424913173
development of a murine infection model with leishmania killicki, responsible for cutaneous leishmaniosis in algeria: application in pharmacology.in algeria, leishmania infantum, leishmania major, and leishmania killicki (leishmania tropica) are responsible for cutaneous leishmaniosis. we established a murine model of l. killicki infection to investigate its infective capacity, some immunophysiopathological aspects, and its suitability for pharmacological purposes. following the injection of l. major or l. killicki metacyclic promastigotes in the ear dermis of balb/c mice, the course of infection was followed. the infection with l. killic ...201626949705
the sandflies of algeria.twenty-two species of sandflies are known to be present in algeria: 12 phlebotomus and 10 sergentomyia. each species has its own ecological distribution except in the mountains of the central sahara where both mediterranean species and species of the ethiopian zoo-geographical area occur together. phlebotomus perniciosus and p. papatasi are the proven vectors of leishmania infantum visceral leishmaniasis and l. major cutaneous leishmaniasis respectively.19911841261
leishmania infantum: lipophosphoglycan intraspecific variation and interaction with vertebrate and invertebrate hosts.interspecies variations in lipophosphoglycan (lpg) have been the focus of intense study over the years due its role in specificity during sand fly-leishmania interaction. this cell surface glycoconjugate is highly polymorphic among species with variations in sugars that branch off the conserved gal(β1,4)man(α1)-po(4) backbone of repeat units. however, the degree of intraspecies polymorphism in lpg of leishmania infantum (syn. leishmania chagasi) is not known. in this study, intraspecific variati ...201021118695
[localized cutaneous leishmaniasis due to leishmania infantum mon-1 contracted in northern algeria].classically, the agent of the sporadic skin leishmaniasis in northern algeria is leishmania infantum mon-24. this paper reports the first documented observation of localized cutaneous leishmaniasis due to leishmania infantum zymodeme mon-1 in northern algeria. the interest of using the western blot serological analysis to guide the diagnosis and the usefulness of the hamster inoculation to isolate leishmania from pauciparasitized lesion is demonstrated.19989642468
phlebotomus (larroussius) perfiliewi naturally infected with dermotropic leishmania infantum at tenes, algeria. 19938249062
[a new enzymatic variant of leishmania infantum nicolle, 1908, agent of cutaneous leishmaniasis in northern algeria].for the first time, the pathogenic agent of cutaneous leishmaniasis in the north of algeria has been identified as leishmania infantum s.1. the parasite was found to be a newly discovered enzymatic variant (zymodeme 24) differing by two electromorphs from a variant isolated in france (zymodeme 11) from the same type of lesion. until now, the dermotropic zymodemes of algeria and france have not been seen in cases of visceral leishmaniasis of the mediterranean basin.19853985532
genetic polymorphism of algerian leishmania infantum strains revealed by multilocus microsatellite analysis.the present study applies multilocus microsatellite typing (mlmt) for studying the polymorphism among 55 strains of leishmania infantum from algeria. these strains from different algerian foci representing different zymodemes, hosts and clinical forms were analysed using 14 microsatellite markers. all 55 strains had individual mlmt profiles and no relationship was observed between them and different host or geographical origins. three populations of algerian l. infantum were identified by a baye ...200818755285
leishmania infantum and l. major in algeria.since 1980, the development of leishmaniasis in algeria has been marked by a considerable increase in the number of cases of both visceral leishmaniasis (1121 cases recorded) and cutaneous leishmaniasis (more than 2000 cases per year). new leishmania infantum and l. major foci have appeared in the north and south of the country. during this period, 100 strains of leishmania isolated from humans, other mammals and sandflies have been identified. the presence of l. major mon-25 in psammomys obesus ...19969015497
application of pcr-rflp for the exploration of the molecular diversity of leishmania infantum in algeria.in recent years, new methods have been developed for the molecular typing of leishmania that need to be extensively validated by studies of clinical isolates in a well defined epidemiological context. the present study is a contribution to this effort. using pcr-rflp of gp63 and cpb genes, we analysed 59 isolates of l. (l.) infantum obtained from different regions of algeria and originating from different clinical forms, hosts and zymodemes. pcr-rflp identified 15 different genotypes among the f ...200818407304
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