inflammation in fetal sheep from intra-amniotic injection of ureaplasma parvum.bronchopulmonary dysplasia is associated with chorioamnionitis and fetal lung inflammation. ureaplasma species are the bacteria most frequently isolated from chorioamnionitis. very chronic ureaplasma colonization of amniotic fluid causes low-grade lung inflammation and functional lung maturation in fetal sheep. less is known about shorter exposures of the fetal lung. therefore, we hypothesized that ureaplasmas would cause an acute inflammatory response that would alter lung development. singleto ...201020935228
maternal administration of erythromycin fails to eradicate intrauterine ureaplasma infection in an ovine model.erythromycin is the standard antibiotic used for treatment of infection with ureaplasma spp. during pregnancy; however, maternally administered erythromycin may be ineffective at eliminating intra-amniotic ureaplasma infections. we examined whether erythromycin would eradicate intra-amniotic ureaplasma infections in pregnant sheep. at gestational day (gd) 50 (term, gd 150), pregnant ewes received intra-amniotic injections of erythromycin-sensitive ureaplasma parvum serovar 3 (n = 16) or 10b medi ...201020610808
ventilation-mediated injury after preterm delivery of ureaplasma parvum colonized fetal lambs.ureaplasma species are the microorganisms most frequently isolated from women with preterm birth and are associated with an increased risk of bronchopulmonary dysplasia. initiation of ventilation with high tidal volumes (vt) causes lung injury and inflammation. we investigated whether antenatal colonization with ureaplasma parvum serovar 3 (up) would alter the inflammatory response to mechanical ventilation of preterm lambs. merino ewes were given intraamniotic injections of up at 55-d gestation ...201020220549
experimental amniotic fluid infection in sheep: effects of ureaplasma parvum serovars 3 and 6 on preterm or term fetal sheep.the objective of the study was to determine the effects in late gestation of ureaplasma parvum serovar 3 colonization and the effects, preterm, of u. parvum serovar 6.200818166324
chronic fetal exposure to ureaplasma parvum suppresses innate immune responses in sheep.the chorioamnionitis associated with preterm delivery is often polymicrobial with ureaplasma being the most common isolate. to evaluate interactions between the different proinflammatory mediators, we hypothesized that ureaplasma exposure would increase fetal responsiveness to lps. fetal sheep were given intra-amniotic (ia) injections of media (control) or ureaplasma parvum serovar 3 either 7 or 70 d before preterm delivery. another group received an ia injection of escherichia coli lps 2 d prio ...201121784974
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