intratypic genome variability of the coxsackievirus b1 2a protease analyse the intratypic genome variability of coxsackievirus b1, 17 coxsackievirus b1 isolates were collected over a period of 10 years. nucleotide sequences of the 2a coding region of the various coxsackievirus b1 isolates and known sequences of other enteroviruses were compared. the maximum diversity observed within the entire group of coxsackievirus b1 isolates was 25%. comparison of deduced amino acid sequences revealed a maximum diversity of 5%. phylogenetic analysis demonstrates a close ...19948126468
genotypic variation in coxsackievirus b5 isolates from three different outbreaks in the united states.genomic sequences in vp1/2a and 5'-non-coding region of 10 isolates of coxsackievirus b5 from three outbreaks were compared with published sequences of another coxsackievirus b5, swine vesicular disease virus, coxsackievirus b1, coxsackievirus b3, and coxsackievirus b4. isolates of coxsackievirus b5 from the same outbreak showed close relations, not exceeding 7.2% in nucleotide differences. differences were greater between isolates from different outbreaks, varying between 8.4 and 16%. we have a ...19958578854
specificity of the coxsackievirus b4 vp4 capsid protein investigated in silico.the enterovirus genus encompasses several species and various serotypes, like coxsackievirus-b1 (cv-b1) to cv-b6, and many variants. the role of these viruses, especially cv-b4, in the pathogenesis of type 1 diabetes is strongly suspected. it has been reported that antibodies directed towards the region of amino acids 11-30 of the vp4 capsid protein enhance the infection of human peripheral blood mononuclear cells with cv-b4. in order to predict the inter- and intra-serotype specificity of the r ...201121878192
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