| natural establishment of thiaminase activity in the alimentary tract of newborn lambs and effects on thiamine status and growth rates. | thiaminase activity was detected in the faeces of lambs at 2 to 5 days of age. levels of activity increased for 10 days and then declined over the next 3 to 4 weeks. decreased erythrocyte transketolase activity indicated thiamine insufficiency in lambs with high thiaminase activity. mean growth rates were 17% less in lambs with high thiaminase activity than in lambs with zero or low thiaminase activity. bacillus thiaminolyticus was the only organism isolated which produced thiaminase. treatment ... | 1987 | 3675411 |
| oral treatment of polioencephalomalacia and subclinical thiamine deficiency with thiamine propyl disulphide and thiamine hydrochloride. | thiaminase type i production by bacillus thiaminolyticus and activity in vitro were repressed by the primary substate thiamine and by thiamine monophosphate and thiamine propyl disulphide. at thiamine concentrations of 300-3000 mumol/l production of active enzyme by b. thiaminolyticus, and activity of purified enzyme, were totally repressed. growth of b. thiaminolyticus was inhibited by thiamine propyl disulphide at 3000 mumol/l. activity of purified thiaminase was lost when incubated with rumin ... | 1986 | 3806781 |
| the effect of thiaminase-induced subclinical thiamine deficiency on growth of weaner sheep. | three experiments were performed to examine for causes of poor growth of young merino sheep. weekly testing of animals 42 weeks of age for 10 weeks revealed that 90% of clinically poor animals were excreting high levels of thiaminase in their faeces; low levels of activity were present in 20% of clinically normal animals. there were significant differences in the mean erythrocyte transketolase activity of the thiaminase excreting poor animals and the thiaminase free normal animals. other known c ... | 1986 | 3962174 |
| thiamin and niacin in the rumen. | thiamin analogs, produced in the rumen by thiaminase i, in the presence of a cosubstrate appear to be responsible for the central nervous system disorder, polioencephalomalacia (pem). for pem to occur, an analog must be produced that inhibits an essential thiamin-requiring reaction, and results from a cosubstrate present in the rumen. in high concentrate diets, thiaminase i is produced by rumen microbes. however, pem can also be caused by thiaminase i of plant origin. based on physical character ... | 1984 | 6386781 |