evidence that cache valley virus induces congenital malformations in outbreak of congenital abnormalities occurred in sheep at san angelo, texas, between december 1986 and february 1987. of 360 lambs born, 19.2% had arthrogryposis or other musculo-skeletal problems and hydranencephaly (agh), and the total neonatal loss was 25.6%. in 1987, all ewes that were tested with agh lambs had antibody to cache valley virus (cvv), whereas 62% of the ewes with normal lambs had cvv-specific antibody. pre-colostral serum samples from agh lambs had neutralizing antibody to c ...19902107620
cache valley virus.cache valley virus (cvv) is a causative agent of a mosquito-borne disease syndrome of sheep and, possibly, of all ruminants, characterized by embryonic and fetal death, stillbirths, and multiple congenital malformations. cvv is endemic in canada, mexico, and the united states. several related bunyaviruses also may play a role in syndromes of congenital malformations and embryonic losses in north america.19947728634
isolations of cache valley virus in texas, 1981.two strains of the same virus (isolates ar 168 and 7856), were isolated in 1981 from an apparently healthy cow and a sick sheep in tx, u.s.a. these isolates were shown to be members of the bunyamwera serogroup (family bunyaviridae, genus bunyavirus) by complement-fixation tests. serum dilution-plaque reduction neutralization test results indicated that the isolates are closely related to cache valley virus. the virus isolates were characterized by sensitivity to lipid solvent, size (50-100 nm by ...19873101276
laboratory investigation of a naturally occurring outbreak of arthrogryposis-hydranencephaly in texas epizootic of abortions, weak lambs, stillbirths, and congenital arthrogryposis-hydranencephaly occurred in a sheep flock in west texas. the outbreak began during the first week of january 1987 and continued through the third week of february 1987. lambs born after february 1987 were not affected. a high incidence of antibodies to cache valley virus (texas 7856 isolate) was demonstrated in the ewes' serum and in precolostral serum from affected lambs. no virus was isolated from tissues and bod ...19892488650
cache valley virus infection in texas sheep flocks.cache valley virus (cvv), an arbovirus indigenous to the united states, has been implicated as an important teratogenic agent in sheep. the prevalence and distribution of texas sheep with cvv-specific antibody were investigated. in 1981, 19.1% of 366 sheep located in 22 counties of texas had antibodies specific for cvv. of 50 flocks examined in the major sheep-producing counties in texas, 34 had sheep with antibodies that reacted with cvv, including all sheep tested in 6 flocks that were seropos ...19911917638
ovine arthrogryposis and central nervous system malformations associated with in utero cache valley virus infection: spontaneous disease.gross appearance and histologic lesions seen in 15 newborn lambs in an outbreak of congenital arthrogryposis with hydrocephalus or hydranencephaly (cah) in texas are described. severe arthrogryposis with skeletal muscle hypoplasia was seen in limbs of affected lambs. spinal column deformities were also present. multiple central nervous system (cns) malformations were present in cah lambs including micrencephaly, cerebellar hypoplasia, micromelia, hydrocephalus, hydranencephaly, and porencephaly. ...19892492399
congenital malformations in sheep resulting from in utero inoculation of cache valley virus.serologic evidence indicated that an episode of congenital abnormalities in sheep was caused by cache valley virus (cvv), a bunyavirus indigenous to the united states. to determine the teratogenic potential of cvv in sheep, fetuses were infected in utero between 27 and 54 days of gestation with an isolate (ck-102) obtained in 1987 from a sentinel sheep in san angelo, texas. the dams of these fetuses were euthanatized between 28 and 75 days after inoculation, and the fetuses were examined for mal ...19902122779
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