Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| subcutaneous, but not intratracheal administration of the tlr9 agonist, cpg dna transiently reduces parainfluenza-3 virus shedding in newborn lambs. | synthetic oligodeoxynucleotides (odn) containing cpg motifs signal through tlr9 and activate innate immunity resulting in protection against a variety of parasitic, bacterial and viral pathogens in mouse models. however, few studies have demonstrated protection in humans and large animals. in the present investigations, we evaluated protection by cpg odn in a parainfluenza-3 (pi-3) virus infection in neonatal lambs. subcutaneous (sc) injection of cpg odn induced high levels of 2'5'-a synthetase ... | 2010 | 20619456 |