Publications

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subcutaneous, but not intratracheal administration of the tlr9 agonist, cpg dna transiently reduces parainfluenza-3 virus shedding in newborn lambs.synthetic oligodeoxynucleotides (odn) containing cpg motifs signal through tlr9 and activate innate immunity resulting in protection against a variety of parasitic, bacterial and viral pathogens in mouse models. however, few studies have demonstrated protection in humans and large animals. in the present investigations, we evaluated protection by cpg odn in a parainfluenza-3 (pi-3) virus infection in neonatal lambs. subcutaneous (sc) injection of cpg odn induced high levels of 2'5'-a synthetase ...201020619456
prevalence of antibodies to bovine respiratory syncytial virus, bovine viral diarrhea virus, bovine herpesvirus-1, and bovine parainfluenza-3 virus in sheep and goats in quebec.serum samples were collected from 1,075 clinically normal sheep and goats from 77 flocks in 7 agricultural regions of quebec from june to august 1982. sheep and goats were tested for antibodies to bovine respiratory syncytial virus, bovine viral diarrhea virus, and bovine herpes-virus-1 by the indirect fluorescent antibody technique and for parainfluenza-3 virus by the hemagglutination inhibition test. the prevalence of antibodies in animals to respiratory syncytial virus was 31%; to bovine vira ...19846089626
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