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bovine aortic endothelial cells are susceptible to hantaan virus infection.hantavirus serotype hantaan (htn) is one of the causative agents of hemorrhagic fever with renal syndrome (hfrs, lethality up to 10%). the natural host of htn is apodemus agrarius. recent studies have shown that domestic animals like cattle are sporadically seropositive for hantaviruses. in the present study, the susceptibility of bovine aortic endothelial cells (baec) expressing alpha(v)beta(3)-integrin to a htn infection was investigated. viral nucleocapsid protein and genomic rna segments wer ...200415033559
hantavirus pulmonary syndrome, central plateau, southeastern, and southern brazil.hantavirus pulmonary syndrome (hps) is an increasing health problem in brazil because of encroachment of sprawling urban, agricultural, and cattle-raising areas into habitats of subfamily sigmodontinae rodents, which serve as hantavirus reservoirs. from 1993 through june 2007, a total of 884 cases of hps were reported in brazil (case-fatality rate 39%). to better understand this emerging disease, we collected 89 human serum samples and 68 rodent lung samples containing antibodies to hantavirus f ...200919331732
bovine and human-derived passive immunization could help slow a future avian influenza pandemic.an epidemic of human transmitted avian influenza could have casualties on a scale seen in the great spanish influenza pandemic of 1918. this paper proposes that should such occur before effective vaccines and antiviral drugs are available, the outbreak could be significantly slowed by consumption of raw milk produced by herds of pathogen-free lactating cows intranasally inoculated with heat-sterilized sputa pooled from avian influenza patients, supplemented by parenteral serum immune globulin fr ...200918824305
new ecological aspects of hantavirus infection: a change of a paradigm and a challenge of prevention--a review.in the last decades a significant number of so far unknown or underestimated pathogens have emerged as fundamental health hazards of the human population despite intensive research and exceptional efforts of modern medicine to embank and eradicate infectious diseases. almost all incidents caused by such emerging pathogens could be ascribed to agents that are zoonotic or expanded their host range and crossed species barriers. many different factors influence the status of a pathogen to remain unn ...200515744574
community ecology of small mammal populations in panamá following an outbreak of hantavirus pulmonary syndrome.in late 1999 and early 2000, an outbreak of hantavirus pulmonary syndrome (hps) occurred in and around los santos, on the azuero peninsula of southwestern panamá. this hps episode, resulting in 22% case fatality, was linked to the costa rican pigmy rice rat, oligoryzomys fulvescens costaricensis, which harbored a then undescribed hantavirus, choclo virus. in addition, cherrie's cane rat, zygodontomys brevicauda cherriei, was identified as carrying a distinct hantavirus, calabazo virus with no kn ...200415266755
bovine aortic endothelial cells are susceptible to hantavirus infection; a new aspect in hantavirus ecology.hantaviruses are enveloped rna viruses that belong to the family bunyaviridae. they are the causative agents of hemorrhagic fever with renal syndrome (hfrs) and hantavirus pulmonary syndrome (hps). hantaviruses show a worldwide distribution with specific rodent species as natural hosts. it is known that rodents can transmit the virus via feces, urine, saliva, or bites to humans. additionally, antibodies against different hantaviruses were also found in domestic animals, for example, danes et al. ...200414972540
hbv core particles as a carrier for b cell/t cell epitopes.in the middle 80s, recombinant hepatitis b virus cores (hbc) gave onset to icosahedral virus-like particles (vlps) as a basic class of non-infectious carriers of foreign immunological epitopes. the recombinant hbc particles were used to display immunodominant epitopes of hepatitis b, c, and e virus, human rhinovirus, papillomavirus, hantavirus, and influenza virus, human and simian immunodeficiency virus, bovine and feline leukemia virus, foot-and-mouth disease virus, murine cytomegalovirus and ...200111509871
a habitat-based model for the spread of hantavirus between reservoir and spillover species.new habitat-based models for spread of hantavirus are developed which account for interspecies interaction. existing habitat-based models do not consider interspecies pathogen transmission, a primary route for emergence of new infectious diseases and reservoirs in wildlife and man. the modeling of interspecies transmission has the potential to provide more accurate predictions of disease persistence and emergence dynamics. the new models are motivated by our recent work on hantavirus in rodent c ...200919616014
in vitro antiviral activity of lactoferrin and ribavirin upon hantavirus.bovine lactoferrin (lf) and ribavirin (rbv) were tested as antiviral agents against seoul type hantavirus (sr-11 strain) in vitro. hantaviral foci number in vero e6 cells infected with sr-11 was reduced with lf treatment by 5 days post infection to obtain a 50% effective dose (ed50) of 2500 microg/ml, while pretreatment with lf was highly efficacious having an ed50 of 39 microg/ml. conversely, 1 h pretreatment with rbv revealed no inhibition of viral focus formation but could significantly reduc ...200011003470
serological evidence for borna disease virus infection in humans, wild rodents and other vertebrates in finland.borna disease virus (bdv) can infect many vertebrate species, including humans. bdv infection may lead to meningoencephalomyelitis in animals. an association with human neuropsychiatric diseases has been reported, but the causal relationship between bdv and human disease remains unclear.200717129759
targeting vascular injury using hantavirus-pseudotyped lentiviral vectors.restenosis is a pathological condition involving intimal hyperplasia and negative arterial remodeling. gene therapy vectors have shown modest therapeutic effects, but the level of infectivity has been relatively poor. in the present study we have designed a modified lentiviral vector (lv) pseudotyped with a strain of hantavirus (htnv) to improve the transduction efficiency into vascular smooth muscle and endothelial cells in vitro and in vivo. in vivo studies using adult new zealand white rabbit ...200616431160
characterization of in vitro and in vivo antiviral activity of lactoferrin and ribavirin upon hantavirus.mechanisms of anti-hantaviral activities of bovine lactoferrin (lf) and ribavirin (rbv) were investigated. hantavirus focus formation at 48 hr was 15% of the control in cells treated with 400 microg/ml lf for 1 hr at 37 degrees c prior to viral infection. post infection treatment with 100 microg/ml rbv also inhibited the focus formation to 2.5% of the control. combined lf pre- and rbv post-infection treatment completely inhibited focus formation. viral glycoprotein (g2) and nucleocapsid protein ...200111459009
evaluation of promed-mail as an electronic early warning system for emerging animal diseases: 1996 to 2004.to identify emerging animal and zoonotic diseases and associated geographic distribution, disease agents, animal hosts, and seasonality of reporting in the program for monitoring emerging diseases (promed)-mail electronic early warning system.200617014355
serum levels of alpha and gamma interferons in hemorrhagic fever with renal syndrome.hemorrhagic fever with renal syndrome is an acute viral disease caused by hantavirus. on the basis of clinical observation, the illness is divided into five sequential stages: febrile, hypotensive, oliguric, diuretic, and convalescent. because interferons can be induced by viruses, and because their stimulating effects on immune cells can alter the course of viral infections, we examined the presence of alpha interferon (ifn-alpha) and gamma interferon (ifn-gamma) in 276 serum samples collected ...19947848512
the public health laboratory service (phls) and its role in the control of zoonotic disease.the aetiology of zoonotic infections embraces organisms from every branch of the microbial world. in addition, zoonoses must be considered as a truly global problem, both in terms of their distribution and the measures required for their control. within the uk, zoonotic disease is considered to be less frequent than in some less developed parts of the world. however, its contribution to overall morbidity and mortality within the uk population is not well established. in an attempt to define the ...200010913770
serologic survey of selected pathogens in white-tailed and mule deer in western nebraska.exposure of free-ranging white-tailed deer (odocoileus virginianus) and mule deer (odocoileus hemionus) in western nebraska to selected livestock pathogens was determined by serology and attempted virus isolation. antibodies to bluetongue virus, epizootic hemorrhagic disease virus, and bovine respiratory syncytial virus were present in both species of deer. no serologic reactors to brucella or anaplasma were found. attempts to isolate bluetongue virus were negative.19862845156
[antibodies against hantaviruses in game and domestic oxen in the czech republic].using the test of indirect immunofluorescence, the authors examined sera of animals for antibodies against the strain cg 18-20 of hantavirus (identical with strain puumala) and against the hantaan strain. as a control and supplement of the examination the authors used cells containing the tbe virus, strain hypr. in a group of 260 hares (lepus europaeus) in 3.5% antibodies were present against hantavirus cg 18-20. of 41 deer (capreolus capreolus) they were present in 14.1%. of 11 fallow-deers non ...19921534516
simple procedure for preparation of bluetongue virus and epizootic hemorrhagic disease virus antigens for agar gel immunodiffusion.a simplified procedure was developed for preparing soluble antigen from two related orbiviruses, bluetongue and epizootic hemorrhagic disease viruses, for agar gel immunodiffusion. the antigens gave excellent results in both micro-agar gel diffusion (agar gel precipitin) and macro-agar gel diffusion (bluetongue immunodiffusion). minor modification in the spatial arrangement of reference antisera, commonly utilized in the agar gel immunodiffusion tests, was employed to reduce the possible develop ...19836140269
viral zoonoses - a threat under control?despite intensive research and considerable effort to eradicate infectious diseases, modern medicine has failed to control many infectious diseases which have been thought to be easy to overcome with advances in medical science and technology. in fact, infectious diseases remain a dominant feature in public health considerations for the 21st century. some infectious agents already known to be pathogenic have gained increasing importance in recent decades due to changes in disease patterns. furth ...200312684545
emerging infectious diseases and pathogens.emerging infectious diseases are caused by old, new, and mutant microorganisms. emergence of these pathogens can be attributed to changes in the characteristics and risk factors of patients, the widespread use of antibiotics, changes in the environment, the role of xenotransplantation, and international travel. in the united states, the incidences of c. difficile, cyclosporiasis, enterohemorrhagic e. coli gastroenteritis, hantavirus, hepatitis c virus infection, and lyme disease have increased s ...199910318733
parasites, diseases and health status of sympatric populations of sambar deer and white-tailed deer in florida.from december 1983 to december 1984 a study on parasites, diseases and health status was conducted on sympatric populations of sambar deer (cervus unicolor) and white-tailed deer (odocoileus virginianus) from st. vincent island, franklin county, florida. ten sambar and six white-tailed deer were examined. white-tailed deer had antibodies to epizootic hemorrhagic disease virus and bluetongue virus. serologic tests for antibodies to the etiologic agents of bovine virus diarrhea, infectious bovine ...19873035242
antibodies against certain bluetongue and epizootic haemorrhagic disease viral serotypes in indonesian ruminants.the orbiviruses contain several important viruses of livestock including bluetongue (bt) and epizootic haemorrhagic disease of deer (ehd) which share some group antigens. preliminary screening of sera for antibodies to orbiviruses by the agar gel immunodiffusion (agid) test has previously revealed widespread infections with the bt group in indonesia. however serum neutralization (sn) tests give a more accurate estimate of exposure to each serotype in the bt and ehd groups, and in this study were ...19911679575
expression of integrin alphavbeta3 in pig, dog and cattle.the alphavbeta3 integrin, also known as vitronectin receptor, is an adhesive glycoprotein that promotes angiogenesis in the embryo and tumors such as melanoma. integrin alphavbeta3 is one of the receptors for adenovirus and hantavirus. there is little information on the constitutive expression of this integrin especially in animal species that are used for biomedical research. we used light and electron microscope immunocytochemistry and western blots to determine integrin alphavbeta3 expression ...200111642723
emerging infectious diseases in the united states, 1993.three outbreaks of disease in the united states in 1993 caused by escherichia coli o157:h7, cryptosporidium organisms, and a previously unrecognized hantavirus clearly illustrate the increasing challenges posed by emerging infectious diseases. the largest us outbreak of e. coli o157:h7 infection reported occurred as a result of contaminated hamburgers served at a fast-food restaurant chain. the largest recorded waterborne disease outbreak in us history was due to contamination of a municipal wat ...19948035009
andes virus recognition of human and syrian hamster beta3 integrins is determined by an l33p substitution in the psi domain.andes virus (andv) causes a fatal hantavirus pulmonary syndrome (hps) in humans and syrian hamsters. human alpha(v)beta(3) integrins are receptors for several pathogenic hantaviruses, and the function of alpha(v)beta(3) integrins on endothelial cells suggests a role for alpha(v)beta(3) in hantavirus directed vascular permeability. we determined here that andv infection of human endothelial cells or syrian hamster-derived bhk-21 cells was selectively inhibited by the high-affinity alpha(v)beta(3) ...201019846530
low prevalence of antibodies against the zoonotic agents brucella abortus, leptospira spp., streptococcus suis serotype ii, hantavirus, and lymphocytic choriomeningitis virus among veterinarians and pig farmers in the southern part of the netherlands.serum samples from 102 veterinarians and 191 pig farmers from the southern part of the netherlands were investigated for antibodies against brucella abortus, leptospira spp, streptococcus suis serotype ii, hantavirus (hv), and lymphocytic choriomeningitis virus (lcmv). all samples were collected in 1993 and stored until this study was performed. the prevalence of antibodies against b.abortus in veterinarians (4.5%) was significantly higher (p = 0.01) than in pig farmers (0%). none of the veterin ...199910321013
serologic survey for hantavirus infection in domestic animals and coyotes from new mexico and northeastern arizona.to determine whether animals had serologic evidence of infection with sin nombre virus (snv).19989540866
serological evidence of thailand virus-related hantavirus infection among suspected leptospirosis patients in kandy, sri lanka.a cross-sectional study was undertaken to determine the current prevalence of leptospirosis and hantaviral infections, and the socio-demographic characteristics and risk factors of infected patients, in kandy, sri lanka. this report discusses the serological evidence of hantavirus infections among 105 suspected leptospirosis patients, 8 of whom had hantavirus antibodies. serotyping elisa showed that these 8 patients had high optical density values for thailand virus. most of the sera showed that ...201121266762
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