Publications

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[the immunogenic properties of marburg virus proteins].immunogenic and protective properties of vp40 and np proteins of marburg virus were studied. vp40 protein was shown to have insignificant immunogenicity and np protein to be capable of protecting the animals from lethal infection by stimulation of cell-mediated immunity. no significant increase in the specific antibody level was found.19921413715
[the detection of the marburg virus antigen by solid-phase immunoenzyme analysis].comparative studies of two variants of the enzyme-linked immunosorbent assay (elisa) were carried out to determine the sensitivity of the detection of marburg virus antigens in vero cells. both competitive and two-antibody elisa variants detected as little as 5 ng of marburg virus antigen. the vero cell monolayer was found to produce 5-50 ng/0.05 ml of the virus-specific proteins at 6 to 8 days postinfection.19911725078
[a comparison of the methods of fluorescent antibodies and solid-phase immunoenzyme analysis in the detection of marburg virus antibodies]. 19911796591
[the sensitivity of different experimental animals to the marburg virus]. 19911803784
[the sensitivity of different cell culture lines to the marburg virus]. 19911803785
[mechanisms of protective immune response in models of marburg fever in monkeys].the parameters of nonspecific immunity (interferon, tumor necrosis factor, natural killers), of spontaneous and mitogen-induced lymphocyte proliferation, of specific immunity (antibodies to marburg virus, antigen-stimulated proliferation) were found to change in the course of experimental marburg fever in immune and intact animals. the named factors were shown to influence the course of the disease; their role in the lethal outcome of the infection was demonstrated.19957676670
[the immunity indices of animals immunized with the inactivated marburg virus after infection with homologous virus].the data on changes in the parameters of specific and nonspecific immunity after challenge of the immunized animals with marburg virus are presented. mediators of the immune response: tumor necrosis factor, interferon, were shown to play different roles in the development of the disease and "protection" of animals. the survival rate of the immunized animals after the challenge with marburg virus was determined by the intensity and level of the immune response after challenge rather than by the l ...19948160440
[survival of marburg virus infectivity on contaminated surfaces and in aerosols].marburg virus was shown to survive for up to 4-5 days on contaminated surfaces. in aerosol it was not stable, the specific rate of its inactivation being 0.05 min-1. this brought the authors to a conclusion that a relatively close contact is needed for virus transmission from man to man, although the possibility of aerosol transmission of the infection may be appreciably increased in case of the hemorrhagic syndrome with a high level of viremia.19968669144
[involvement of internal organs of experimental animals infected with marburg disease virus]. 19949296679
differential induction of cellular detachment by envelope glycoproteins of marburg and ebola (zaire) viruses.human infection by marburg (mbg) or ebola (ebo) virus is associated with fatal haemorrhagic fevers. while these filoviruses may both incite disease as a result of explosive virus replication, we hypothesized that expression of individual viral gene products, such as the envelope glycoprotein (gp), may directly alter target cells and contribute to pathogenesis. we found that expression of ebo gp in 293t cells caused significant levels of cellular detachment in the absence of cell death or virus r ...200010950971
[ebola and marburg viruses: the humans strike back].ebola and marburg viruses are the causative agents of rapidly progressive hemorrhagic fevers with high mortality rates. pre- or post-exposure treatments against the diseases are currently not available for human use. in the field, establishment of strict quarantine measures preventing further virus transmission are still the only way to fight the infections. however, our knowledge of ebola and marburg viruses has markedly increased as a result of two recent discoveries discussed in this review. ...200616597410
laboratory diagnosis of ebola and marburg hemorrhagic fever.the control of filovirus outbreaks can be greatly enhanced by timely laboratory confirmation of infection or the identification of alternative disease processes. the status of current laboratory diagnostics for ebola and marburg virus infections is discussed in terms of the assays available and their interpretation. in addition, the role of field-based laboratory support and its limitations and capabilities in an outbreak response setting, especially in regards to real-time pcr and immunofiltrat ...200516267962
inactivated marburg virus elicits a nonprotective immune response in rhesus monkeys.in the present work the kinetics of some indices of immunity (tumor necrosis factor (tnf), interferon (ifn), natural killer cells (nk), lymphocyte proliferation activity, virus-specific antibodies, cd4/cd8 ratio) in response to marburg virus infection in macaca mulatta were studied. the different kinetics of immunological parameters for animals which survived marburg virus infection and for animals which died after infection are shown. a comparison of the indices of ifn, tnf and spontaneous lymp ...19968717394
[a comparative study of the in-vitro interaction of the marburg virus with macrophages from different animal species].the amplification of marburg virus in primary cultures of peritoneal macrophages of animals with different sensitivity to infection with this virus, as well as the capacity of this virus to adsorb on macrophages were studied. macrophages of the animals sensitive to marburg virus were capable to support its reproduction in vitro whereas those of resistant animals were not. macrophages of the animals with intermediate sensitivity were shown to be either completely resistant to virus reproduction o ...19911785187
the use of interferon for emergency prophylaxis of marburg hemorrhagic fever in monkeys.the possibility of emergency prophylaxis of marburg hemorrhagic fever with leukocytic and recombinant interferons was studied in experiments on cercopithecus aethiops. none of the agents protected monkeys from the action of lethal doses of marburg virus. recombinant interferon-alpha(2)administered according to the emergency prophylaxis schedule prolonged the mean life-span of monkeys injected with marburg virus in doses of 100 and 1000 ld50 by 1.9 and 6.1 days, respectively.200111687854
[the effect of the methods for producing an experimental marburg virus infection on the characteristics of the course of the disease in green monkeys].a comparative study on the features of the pathogenesis of marburg disease after parenteral and aerosol infection of green monkeys with a virus prepared from native culture suspension and that after lyophilization was carried out. the changes in the dynamics of the clotting time, the activity of serum aminotransferases, the duration of prefebrile period and survival time were analysed in different cases. no lethality was observed in animals infected with small doses of aerosol preparations.19921441442
the survival of filoviruses in liquids, on solid substrates and in a dynamic aerosol.filoviruses are associated with high morbidity and lethality rates in humans, are capable of human-to-human transmission, via infected material such as blood, and are believed to have low infectious doses for humans. filoviruses are able to infect via the respiratory route and are lethal at very low doses in experimental animal models, but there is minimal information on how well the filoviruses survive within aerosol particles. there is also little known about how well filoviruses survive in li ...201020553340
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