Publications

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a history of biological disasters of animal origin in north america.this paper examines past occurrences in north america relevant to the possibility of biological disasters with animal origins. with respect to naturally occurring animal disease outbreaks, north america, while not as adversely affected by epizootics as other regions, has had its fair share of such outbreaks of both 'traditional' and emerging animal diseases. the traditional category includes such diseases as anthrax, classical swine fever, bluetongue, brucellosis, foot and mouth disease, and the ...200616796038
emerging viral diseases. 200011035785
low prevalence of antibodies against the zoonotic agents brucella abortus, leptospira spp., streptococcus suis serotype ii, hantavirus, and lymphocytic choriomeningitis virus among veterinarians and pig farmers in the southern part of the netherlands.serum samples from 102 veterinarians and 191 pig farmers from the southern part of the netherlands were investigated for antibodies against brucella abortus, leptospira spp, streptococcus suis serotype ii, hantavirus (hv), and lymphocytic choriomeningitis virus (lcmv). all samples were collected in 1993 and stored until this study was performed. the prevalence of antibodies against b.abortus in veterinarians (4.5%) was significantly higher (p = 0.01) than in pig farmers (0%). none of the veterin ...199910321013
neutralizing human monoclonal antibodies against puumala virus, causative agent of nephropathia epidemica: a novel method using antigen-coated magnetic beads for specific b cell isolation.human monoclonal antibodies (mabs) against puumala (puu) virus were generated and characterized. human spleen b lymphocytes were preselected for specific surface immunoglobulin (ig) using magnetic beads coated with the viral glycoproteins, and subsequently immortalized by epstein-barr virus transformation. four igg-positive monoclonal lymphoblastoid cell lines (lcls) were established and have remained stable mab secretors for over 12 months. analyses of the antigen and epitope specificities reco ...19937687648
viral zoonoses - a threat under control?despite intensive research and considerable effort to eradicate infectious diseases, modern medicine has failed to control many infectious diseases which have been thought to be easy to overcome with advances in medical science and technology. in fact, infectious diseases remain a dominant feature in public health considerations for the 21st century. some infectious agents already known to be pathogenic have gained increasing importance in recent decades due to changes in disease patterns. furth ...200312684545
new ecological aspects of hantavirus infection: a change of a paradigm and a challenge of prevention--a review.in the last decades a significant number of so far unknown or underestimated pathogens have emerged as fundamental health hazards of the human population despite intensive research and exceptional efforts of modern medicine to embank and eradicate infectious diseases. almost all incidents caused by such emerging pathogens could be ascribed to agents that are zoonotic or expanded their host range and crossed species barriers. many different factors influence the status of a pathogen to remain unn ...200515744574
high seroprevalence of hantavirus infection on the azuero peninsula of panama.the first outbreak of hantavirus pulmonary syndrome (hps) in central america was documented on the azuero peninsula of panama in late 1999 and 2000. reverse transcriptase-polymerase chain reaction evidence implicated only choclo virus in symptomatic hps with a mortality rate of 20%, although two rodent-borne hantaviruses (choclo virus and calabazo virus) were identified in the peridomestic habitat. neighborhood serosurveys around case households found seroprevalence rates as high as 30%, the hig ...200415211014
isolation of the causative agent of hantavirus pulmonary syndrome.investigation of a recent outbreak of acute respiratory illness in the southwestern united states resulted in the recognition of a new disease, hantavirus pulmonary syndrome (hps) with high mortality. different animals and cell lines were used in attempts to isolate the causative agent. a previously unknown hantavirus was passaged in laboratory-bred deer mice, recovered from lung tissues of a deer mouse, peromyscus maniculatus, and propagated in the e6 clone of vero cells. virus antigen was read ...19948059907
observations on natural and laboratory infection of rodents with the etiologic agent of korean hemorrhagic fever.studies were conducted to define the natural host range of the korean hemorrhagic fever (khf) agent in south korea, and to identify colonized rodents susceptible to this infection. eight species of field rodents were captured in areas of korea endemic for khf and their tissues were examined by immunofluorescence for the presence of khf antigen. one hundred and fourteen of 817 apodemus agrarius coreae captured between 1974 and 1978 had one or more positive organs. no positive organ was found in 2 ...19816786119
parasites, diseases and health status of sympatric populations of sambar deer and white-tailed deer in florida.from december 1983 to december 1984 a study on parasites, diseases and health status was conducted on sympatric populations of sambar deer (cervus unicolor) and white-tailed deer (odocoileus virginianus) from st. vincent island, franklin county, florida. ten sambar and six white-tailed deer were examined. white-tailed deer had antibodies to epizootic hemorrhagic disease virus and bluetongue virus. serologic tests for antibodies to the etiologic agents of bovine virus diarrhea, infectious bovine ...19873035242
[study on the serological typing of patients with epidemic hemorrhagic fever (ehf) and host animals in junan county, shangdong province].using hemagglutination inhibition test (hi), we confirmed that junan county is an endemic area of both ehf of r. norvegicus and a. agrarius, which indicated that the main host animals were r. norvegicus and a. agrarius in the area. remarkable difference was shown between the infectious rates of pigs from the endemic area and that of pigs from the nonendemic area, which suggested that pigs could play certain roles in the transmission of ehf. we also proved that the main transmission mode of ehf v ...19921356628
expression of integrin alphavbeta3 in pig, dog and cattle.the alphavbeta3 integrin, also known as vitronectin receptor, is an adhesive glycoprotein that promotes angiogenesis in the embryo and tumors such as melanoma. integrin alphavbeta3 is one of the receptors for adenovirus and hantavirus. there is little information on the constitutive expression of this integrin especially in animal species that are used for biomedical research. we used light and electron microscope immunocytochemistry and western blots to determine integrin alphavbeta3 expression ...200111642723
serological evidence of hantaan-related viruses in hong kong.sera from rats (rattus norvegicus), domestic animals and man in hong kong were studied by immunofluorescent antibody assay and plaque reduction neutralization tests for evidence of infection by hantaan-related viruses. antibody probably arising from infection by seoul or a seoul-like virus was detected in rat and human sera (and one pig serum), highlighting the potential public health importance of this group of viruses in hong kong, and in the region.19873120366
[study on the surveillance of house-rat type epidemic haemorrhagic fever]. 19882905938
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