infant immune response to human rotavirus serotype g1 vaccine candidate reassortant wi79-9: different dose response patterns to virus surface proteins vp7 and vp4.rotavirus is the leading cause of morbidity from gastroenteritis in the developed world and the leading cause of mortality from viral gastroenteritis (estimated 600000 deaths) worldwide. g1 is the most prevalent human serotype. reassortant rotavirus between simian rotavirus rrv or bovine rotavirus wc3 and human strain rotaviruses have been extensively tested as candidate vaccines. rotavirus (rv) reassortant strain wi79-9 consists of a human (strain wi79) g1 serotype vp7 surface protein on a bovi ...200415014293
prospects for development of a rotavirus vaccine against rotavirus diarrhea in infants and young children.major advances have been made in elucidating the etiologic agents of severe infantile diarrhea, and it is clear that rotaviruses are the single most important etiologic agents. progress in the development of rotavirus vaccine candidates has also moved swiftly with the "jennerian" approach, in which a related live, attenuated rotavirus strain from a nonhuman host is used as the immunizing antigen. if this strategy is not effective against all rotavirus serotypes, reassortant rotaviruses hold grea ...19892548276
safety and immunogenicity of live attenuated quadrivalent human-bovine (uk) reassortant rotavirus vaccine administered with childhood vaccines to infants.the safety and immunogenicity of an orally administered, live rotavirus vaccine comprised of four strains, each with a titer of 10(5.3) or 10(5.8) pfu, and each having 10 genes from the uk bovine strain and the vp7 gene from human rotavirus serotype 1, 2, 3, or 4, were evaluated in adults, young children and infants in randomized, double-blind phase 1 trials. three doses of rotavirus vaccine or placebo given with childhood immunizations to infants at 2, 4, and 6 months of age were well tolerated ...200111535316
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