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anti-insulin antibodies in dogs with naturally occurring diabetes mellitus.the presence of anti-insulin antibodies was determined by elisa in serum samples from 30 diabetic dogs receiving bovine insulin therapy and 30 normoglycaemic dogs. twenty of the diabetic dogs had significant reactivity to both bovine (heterologous) and porcine (homologous) insulin compared to control dogs. in contrast there was no significant difference between the two populations in reactivity to canine distemper virus (cdv) or canine thyroglobulin. the high degree of correlation between anti-b ...200312507850
the interaction of cells persistently infected with canine distemper virus with antiviral antibody and complement.cells persistently infected with canine distemper virus can be lysed by antibody and complement. this reaction is dependent upon the alternative complement pathway. in the absence of antiviral antibody, the virus-infected cells will activate the alternative complement pathway, although this will not produce cell lysis.19836850842
alkoxyalkyl esters of cidofovir and cyclic cidofovir exhibit multiple-log enhancement of antiviral activity against cytomegalovirus and herpesvirus replication in vitro.the incidence of cytomegalovirus (cmv) retinitis is declining in aids patients but remains a significant clinical problem in patients with organ transplants and bone marrow transplants. prophylaxis with ganciclovir (gcv) or valganciclovir reduces the incidence of cmv disease but may lead to the emergence of drug-resistant virus with mutations in the ul97 or ul54 gene. it would be useful to have other types of oral therapy for cmv disease. we synthesized hexadecyloxypropyl and octadecyloxyethyl d ...200212121908
membrane fusion tropism and heterotypic functional activities of the nipah virus and hendra virus envelope glycoproteins.nipah virus (niv) and hendra virus (hev) are novel paramyxoviruses from pigs and horses, respectively, that are responsible for fatal zoonotic infections of humans. the unique genetic and biological characteristics of these emerging agents has led to their classification as the prototypic members of a new genus within the paramyxovirinae subfamily called henipavirus: these viruses are most closely related to members of the genus morbillivirus and infect cells through a ph-independent membrane fu ...200212388678
antiserum raised in pigs against canine distemper virus and its utility in diagnostic procedures for morbillivirus infections (canine distemper, phocine distemper, rinderpest).antiserum against canine distemper virus (cdv) was raised in pigs by intranasal inoculation with cdv strains cnd65 and rockborn. immunoglobulin fractions were conjugated with horseradish peroxidase. peroxidase-conjugated anti-cdv immunoglobulin preparations were used for the detection and titration of cdv, seal-derived (phocine) distemper virus (pdv) and rinderpest virus (rpv) in vero cell cultures. for the detection and titration of corresponding neutralizing antibodies a direct neutralizing pe ...19902396484
anti-insulin antibodies in diabetic dogs before and after treatment with different insulin preparations.anti-insulin antibodies (aia) occur in diabetic dogs after insulin therapy, although their clinical significance is unclear.200818976287
host range and receptor utilization of canine distemper virus analyzed by recombinant viruses: involvement of heparin-like molecule in cdv infection.we constructed recombinant viruses expressing enhanced green fluorescent protein (egfp) or firefly luciferase from cdna clones of the canine distemper virus (cdv) (a japanese field isolate, yanaka strain). using these viruses, we examined susceptibilities of different cell lines to cdv infection. the results revealed that the recombinant cdvs can infect a broad range of cell lines. infectivity inhibition assay using a monoclonal antibody specific to the human slam molecule indicated that the inf ...200717055025
epizootic canine distemper virus infection among wild mammals.in the spring of 2007, seven raccoon dogs and a weasel were captured near the city of tanabe in wakayama prefecture, japan. the causative agent of the animals' death 1-2days after capture was identified as canine distemper virus (cdv) by virus isolation, immunostaining with an anti-cdv polyclonal antibody, and a commercially available cdv antigen-detection kit. sequence analysis of hemagglutinin genes indicated the isolated viruses belong to genotype asia-1 and possess the substitution from tyro ...201121840141
[combined use of killed vaccines and immunomodulator ridostin for urgent prevention of epidemic stomatitis, aujeszky disease and carnivore plague in experiment].results of experimental studies of mice and pigs infected with foot-and-mouth disease virus, minks infected with aujeszky's disease virus, and dogs infected with canine distemper virus are described. in animals with foot-and-mouth disease and aujeszky's disease, combined treatment with killed vaccine and immunomodulator ridostin by the scheme of urgent prophylaxis (3 days before infection) caused 75% (foot-and-mouth disease) and 100% (aujeszky's disease) prevention of animal death and developmen ...200212508681
[immunosuppression in dogs and pigs infected with canine distemper virus].immunosuppression manifesting itself as leukopenia and a considerably lower lymphocyte proliferative response to t- and b-cell mitogens develops in pigs and dogs within 2-3 weeks after intramuscular or oral infection with canine distemper virus (cdv). cdv antigens are detectable in the oral secretions of the animals within 2-2.5 week after infection.201122171479
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