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a new insect-specific flavivirus from northern australia suppresses replication of west nile virus and murray valley encephalitis virus in co-infected mosquito cells.recent reports of a novel group of flaviviruses that replicate only in mosquitoes and appear to spread through insect populations via vertical transmission have emerged from around the globe. to date, there is no information on the presence or prevalence of these insect-specific flaviviruses (isfs) in australian mosquito species. to assess whether such viruses occur locally, we used reverse transcription-polymerase chain reaction (rt-pcr) and flavivirus universal primers that are specific to the ...201323460804
comparative susceptibility of mosquito populations in north queensland, australia to oral infection with dengue virus.dengue is the most prevalent arthropod-borne virus, with at least 40% of the world's population at risk of infection each year. in australia, dengue is not endemic, but viremic travelers trigger outbreaks involving hundreds of cases. we compared the susceptibility of aedes aegypti mosquitoes from two geographically isolated populations to two strains of dengue virus serotype 2. we found, interestingly, that mosquitoes from a city with no history of dengue were more susceptible to virus than mosq ...201424420782
weather-driven variation in dengue activity in australia examined using a process-based modeling approach.the impact of weather variation on dengue transmission in cairns, australia, was determined by applying a process-based dengue simulation model (densim) that incorporated local meteorologic, entomologic, and demographic data. analysis showed that inter-annual weather variation is one of the significant determinants of dengue outbreak receptivity. cross-correlation analyses showed that densim simulated epidemics of similar relative magnitude and timing to those historically recorded in reported d ...201223166197
bionomic response of aedes aegypti to two future climate change scenarios in far north queensland, australia: implications for dengue outbreaks.dengue viruses are transmitted by anthropophilic mosquitoes and infect approximately 50 million humans annually. to investigate impacts of future climate change on dengue virus transmission, we investigated bionomics of the mosquito vector, aedes aegypti.201425240382
epidemiology of dengue in a high-income country: a case study in queensland, australia.australia is one of the few high-income countries where dengue transmission regularly occurs. dengue is a major health threat in north queensland (nq), where the vector aedes aegypti is present. whether nq should be considered as a dengue endemic or epidemic region is an ongoing debate. to help address this issue, we analysed the characteristics of locally-acquired (la) and imported dengue cases in nq through time and space. we describe the epidemiology of dengue in nq from 1995 to 2011, to iden ...201425138897
emergence of a new lineage of dengue virus type 2 identified in travelers entering western australia from indonesia, 2010-2012.dengue virus (denv) transmission is ubiquitous throughout the tropics. more than 70% of the current global dengue disease burden is borne by people who live in the asia-pacific region. we sequenced the e gene of denv isolated from travellers entering western australia between 2010-2012, most of whom visited indonesia, and identified a diverse array of denv1-4, including multiple co-circulating viral lineages. most viruses were closely related to lineages known to have circulated in indonesia for ...201525635775
unforeseen costs of cutting mosquito surveillance budgets.a budget proposal to stop the u.s. centers for disease control and prevention (cdc) funding in surveillance and research for mosquito-borne diseases such as dengue and west nile virus has the potential to leave the country ill-prepared to handle new emerging diseases and manage existing ones. in order to demonstrate the consequences of such a measure, if implemented, we evaluated the impact of delayed control responses to dengue epidemics (a likely scenario emerging from the proposed cdc budget ...201021049010
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