Publications

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vaccinia recombinant virus expressing the rabies virus glycoprotein: safety and efficacy trials in canadian wildlife.twenty-six meadow voles (microtus pennsylvanicus), ten woodchucks (marmota monax), thirteen grey squirrels (sciurus carolinensis), thirteen ring-billed gulls (larus delawarensis), six red-tailed hawks (buteo jamaicensis) and eight great horned owls (bubo virginianus) received vaccinia virus recombinant expressing the rabies virus glycoprotein (v-rg) by direct instillation into the oral cavity. each of ten coyotes (canis latrans) received the virus in two vaccine-laden baits. several voles and mo ...19902249183
animal rabies in massachusetts, 1985-2006.in this study, we review annual rabies data from massachusetts from 1985 to 2006, spanning the introduction of raccoon strain rabies in 1992. of 52,034 animals tested, 9.7% (5,049/52,034) were rabid, representing 26 of over 67 species submitted. bats were the most common rabid animals prior to 1992 (50 of 52), but raccoons (procyon lotor) became the most common rabies-positive species upon arrival of raccoon strain rabies virus (38.2%, 2,728 of 7,138 tested), followed by striped skunks (mephitis ...200919395747
host and viral traits predict zoonotic spillover from mammals.the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ...201728636590
serial passage of a street rabies virus in mouse neuroblastoma cells resulted in attenuation: potential role of the additional n-glycosylation of a viral glycoprotein in the reduced pathogenicity of street rabies virus.street rabies viruses are field isolates known to be highly neurotropic. however, the viral elements related to their pathogenicity have yet to be identified at the nucleotide or amino acid level. here, through 30 passages in mouse neuroblastoma na cells, we have established an attenuated variant of street rabies virus strain 1088, originating from a rabid woodchuck followed by 2 passages in the brains of suckling mice. the variant, 1088-n30, was well adapted to na cells and highly attenuated in ...201222248643
rabies in rodents and lagomorphs in the united states, 1995-2010.to assess the epidemiology of rabies in rodents and lagomorphs and provide information that will enable public health officials to make recommendations regarding postexposure prophylaxis for humans after contact with these animals.201425029313
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