Publications

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n-ethyl-n'-nitro-n-nitrosoguanidine induced gastric carcinoma in wolfdogs--useful animal model for tracing gastric malignancy transformation. 19863034516
rabies in a vaccinated wolf-dog hybrid.in march 1993, an 11-month-old neutered male wolf-dog hybrid with a 5-day history of progressive neurologic signs was determined to have rabies. the animal was currently vaccinated for rabies with a usda-approved canine rabies vaccine. one month prior to becoming ill, the animal was observed carrying a dead skunk in its enclosure in a rabies-endemic foothills region of northern california. the diagnosis was made by direct fluorescent antibody testing and confirmed by use of polymerase chain reac ...19947744645
immunohistochemical evaluation of a malignant phecochromocytoma in a wolfdog.a malignant pheochromocytoma with multiple metastases was diagnosed in a 7-year-old male wolfdog that resulted from a cross between an eastern timber wolf (canis lupus lycaon) and an alaskan malamute. a yellowish white neoplastic mass approximately 10 cm diameter was found in the right adrenal gland. the neoplasm penetrated through the wall of the caudal vena cava. a diagnosis of pheochromocytoma was established by histopathologic and immunohistochemical procedures. immunohistochemically, the ne ...200111467480
social communication in canids: evidence for the evolution of a stereotyped mammalian display.the variability in the duration and form of the canid play bow was studied in infant coyotes, wolves, wolf-dog hybrids, beagles, and adult free-ranging dogs. both duration and form showed marked stereotypy. it appears that the role of this context-specific social signal in the communication of play intention has been fostered by selection for "morphological" stereotypy.197717836077
real-time assessment of hybridization between wolves and dogs: combining noninvasive samples with ancestry informative markers.wolves and dogs provide a paradigmatic example of the ecological and conservation implications of hybridization events between wild and domesticated forms. however, our understanding of such implications has been traditionally hampered by both high genetic similarity and the difficulties in obtaining tissue samples (ts), which limit our ability to assess ongoing hybridization events. to assess the occurrence and extension of hybridization in a pack of wolf-dog hybrids in northwestern iberia, we ...201525132482
from wolves to dogs, and back: genetic composition of the czechoslovakian wolfdog.the czechoslovakian wolfdog is a unique dog breed that originated from hybridization between german shepherds and wild carpathian wolves in the 1950s as a military experiment. this breed was used for guarding the czechoslovakian borders during the cold war and is currently kept by civilian breeders all round the world. the aim of our study was to characterize, for the first time, the genetic composition of this breed in relation to its known source populations. we sequenced the hypervariable par ...201526636975
spatial assessment of wolf-dog hybridization in a single breeding period.understanding the dynamics of wolf-dog hybridization and delineating evidence-based conservation strategies requires information on the spatial extent of wolf-dog hybridization in real-time, which remains largely unknown. we collected 332 wolf-like scats over ca. 5,000km(2) in the nw iberian peninsula to evaluate wolf-dog hybridization at population level in a single breeding/pup-rearing season. mitochondrial dna (mtdna) and 18 ancestry informative markers were used for species and individual id ...201728195213
fibrosarcoma of the eyelid in two sibling czech wolfdogs.most canine tumors of the eyelid are tumors generally encountered in the skin. they are most commonly of epithelial origin and benign. in this report, we describe the cases of two sibling czech wolfdogs presented, one year apart, with a subcutaneous mass involving the left eyelid. both lesions were histologically consistent with a diagnosis of subcutaneous fibrosarcoma. immunohistochemical analyses of the tumors revealed a mild positivity for vimentin and negativity for gfap, desmin, ╬▒sma, myogl ...201728616389
wolves recolonizing islands: genetic consequences and implications for conservation and management.after a long and deliberate persecution, the grey wolf (canis lupus) is slowly recolonizing its former areas in europe, and the genetic consequences of this process are of particular interest. wolves, though present in mainland estonia for a long time, have only recently started to recolonize the country's two largest islands, saaremaa and hiiumaa. the main objective of this study was to analyse wolf population structure and processes in estonia, with particular attention to the recolonization o ...201627384049
cytophotometric dna analysis on canine stomach carcinogenesis induced by enng.dna content and nuclear area were measured by microspectrophotometry in gastric carcinogenesis of three adult wolfdogs induced by n-ethyl-n'-nitro-n-nitrosoguanidine (enng). the mean values and standard deviations of dna content and nuclear area in normal gastric mucosa were 10.03 +/- 2.30 au and 28.76 +/- 5.85/microns2; those in atrophic gastritis were 12.04 +/- 3.34 au and 28.69 +/- 8.02/microns2; in mild dysplasia 13.52 +/- 3.73 au and 28.23 +/- 8.12/microns2; in moderate dysplasia 20.88 +/- ...19902127246
multilocus detection of wolf x dog hybridization in italy, and guidelines for marker selection.hybridization and introgression can impact the evolution of natural populations. several wild canid species hybridize in nature, sometimes originating new taxa. however, hybridization with free-ranging dogs is threatening the genetic integrity of grey wolf populations (canis lupus), or even the survival of endangered species (e.g., the ethiopian wolf c. simensis). efficient molecular tools to assess hybridization rates are essential in wolf conservation strategies. we evaluated the power of bipa ...201424466077
atlanto-axial malformation and instability in dogs with pituitary dwarfism due to an lhx3 mutation.canine pituitary dwarfism or combined pituitary hormone deficiency (cphd) in shepherd dogs is associated with an lhx3 mutation and can lead to a wide range of clinical manifestations. some dogs with cphd have neurological signs that are localized to the cervical spine. in human cphd, caused by an lhx3 mutation, anatomical abnormalities in the atlanto-axial (c1-c2) joint have been described.201525586673
seasonal trends in intrapack aggression of captive wolves (canis lupus) and wolf-dog crosses: implications for management in mixed-subspecies exhibits.mixed-species exhibits are becoming increasingly common in the captive management of a wide range of species. systematic evaluations of enclosures consisting of multiple subspecies, however, are relatively infrequent. the aim of this study was to measure seasonal trends in aggressive behaviors within a captive pack of wolves and wolf-dog crosses in a sanctuary setting. the frequency of intrapack social behaviors occurring within scan-sampling intervals was recorded for wolves and wolf-dog crosse ...201524940635
rabies vaccination of wolf-dog hybrids. 19957768682
retrospective analysis of co-occurrence of congenital aortic stenosis and pulmonary artery stenosis in dogs.the study has focused on the retrospective analysis of cases of coexisting congenital aortic stenosis (as) and pulmonary artery stenosis (ps) in dogs. the research included 5463 dogs which were referred for cardiological examination (including clinical examination, ecg and echocardiography) between 2004 and 2014. aortic stenosis and ps stenosis were detected in 31 dogs. this complex defect was the most commonly diagnosed in boxers - 7 dogs, other breeds were represented by: 4 cross-breed dogs, 2 ...201526812828
combined use of maternal, paternal and bi-parental genetic markers for the identification of wolf-dog hybrids.the identification of hybrids is often a subject of primary concern for the development of conservation and management strategies, but can be difficult when the hybridizing species are closely related and do not possess diagnostic genetic markers. however, the combined use of mitochondrial dna (mtdna), autosomal and y chromosome genetic markers may allow the identification of hybrids and of the direction of hybridization. we used these three types of markers to genetically characterize one possi ...200312522421
bucking the trend in wolf-dog hybridization: first evidence from europe of hybridization between female dogs and male wolves.studies on hybridization have proved critical for understanding key evolutionary processes such as speciation and adaptation. however, from the perspective of conservation, hybridization poses a concern, as it can threaten the integrity and fitness of many wild species, including canids. as a result of habitat fragmentation and extensive hunting pressure, gray wolf (canis lupus) populations have declined dramatically in europe and elsewhere during recent centuries. small and fragmented populatio ...201223056315
naturally occurring tyzzer's disease in a puppy.a naturally occurring case of tyzzer's disease due to infection with bacillus piliformis in a wolf-dog hybrid resulted in widely disseminated lesions, including severe myocarditis, hepatitis, enterocolitis, intestinal leiomyositis, and adrenal cortical adenitis. previously reported lesions for canine tyzzer's disease have been limited to hepatic necrosis and a necrotizing enterocolitis.19957725599
pituitary dwarfism in saarloos and czechoslovakian wolfdogs is associated with a mutation in lhx3.pituitary dwarfism in german shepherd dogs is associated with autosomal recessive inheritance and a mutation in lhx3, resulting in combined pituitary hormone deficiency. congenital dwarfism also is encountered in breeds related to german shepherd dogs, such as saarloos and czechoslovakian wolfdogs.201725273400
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