| formulation and evaluation of an alternative triglyceride-free propofol microemulsion. | a new triglyceride-free propofol microemulsion for intravenous injection was formulated using nonionic surfactants, poloxamers and polyethylene glycol 660 hydroxystearate. the aim of this investigation was to evaluate the formulation for storage stability, antimicrobial activity, toxicity and preclinical efficacy. the results were compared to the characteristics obtained for the most commonly used formulation of propofol (diprivan®). the mean particle diameter of the microemulsion was less than ... | 2010 | 20945136 |
| nasal polyposis: a study of its association with airborne allergen hypersensitivity. | despite the frequent presence of clinical symptoms such as sneezing and itching, elevated histamine and ige in extracellular polyp fluids, tissue eosinophilia, and degranulated mast cells, allergy is not considered an important cause of nasal polyposis. | 2001 | 11289325 |
| systemic candidiasis and mesenteric mast cell tumor with multiple metastases in a dog. | a 5-year-old female miniature dachshund presenting with persistent vomiting and diarrhea had two concurrent rare pathological conditions: systemic candidiasis and mesenteric mast cell tumor with multiorgan metastases. neoplastic mast cells formed mass in the mesentery of the cecal-colonic region and were also found in the liver, spleen, kidneys, lungs, adrenal grands, ovaries, bone marrow and other tissues. the cells had intracytoplasmic granules with metachromasia and were immunohistochemically ... | 2009 | 19262039 |
| molecular cloning and characterization of three beta-defensins from canine testes. | mammalian beta-defensins are small cationic peptides possessing broad antimicrobial and physiological activities. because dogs are particularly resilient to sexually transmitted diseases, it has been proposed that their antimicrobial peptide repertoire might provide insight into novel antimicrobial therapeutics and treatment regimens. to investigate this proposal, we cloned the full-length cdna of three canine beta-defensin isoforms (cbd-1, -2, and -3) from canine testicular tissues. their predi ... | 2005 | 15845463 |
| comparison of lns-amb, a novel low-dose formulation of amphotericin b with lipid nano-sphere (lns), with commercial lipid-based formulations. | three lipid-based delivery systems (ambisome, amphocil, and abelcet) for amphotericin b (amb) have been marketed to overcome the disadvantages associated with the clinical use of amb. however, to show their efficacy, they need to be administered at higher doses than the conventional dosage form, fungizone. in this study, we compared lns-amb, our new low-dose therapeutic system for amb using lipid nano-sphere (lns), with these commercial formulations in terms of their pharmacokinetics and efficac ... | 2003 | 14602388 |
| t-8581, a new orally and parenterally active triazole antifungal agent: in vitro and in vivo evaluations. | t-8581 is a new water-soluble triazole antifungal agent. the geometric mean ic80s (gm-ic80s; where the ic80 is the lowest drug concentration which reduced the optical density at 630 nm by 80% compared with the optical density at 630 nm of the drug-free control) for candida albicans were as follows: t-8581, 0.218 microgram/ml; fluconazole; 0.148 microgram/ml; and itraconazole, 0.0170 microgram/ml. for cryptococcus neoformans the gm-ic80s were as follows: t-8581, 9.28 micrograms/ml; fluconazole, 4 ... | 1997 | 8980750 |
| [amphotericin b: its characteristics and means of application]. | | 1982 | 6758683 |
| granulocyte transfusions in leukopenic dogs: in vivo and in vitro function of granulocytes obtained by continuous-flow filtration leukopheresis. | | 1974 | 4206915 |
| [disseminated candidiasis (moniliasis) in a dog. a case report]. | a case of systemic candidiasis (candida albicans) in a 1 1/2 year old dog is reported. clinically, the first manifestation was enlargement of a superficial inguinal lymph node. later several peripheral lymph nodes were affected and a fistulous opening appeared, communicating with an inflammatory process in the right humerus. necropsy revealed gross lesions in the kidneys, pancreas and multiple lymph nodes. in addition, microscopic lesions were observed in the myocardium and the bone marrow of th ... | 1982 | 6757853 |
| "candida" sepsis: portals for invasion, tissue filtration, and principles of treatment. | | 1975 | 817806 |
| pathophysiology of candida albicans meningitis in normal, neutropenic, and granulocyte transfused dogs. | | 1980 | 6986922 |
| is interleukin-1 alpha a direct activator of neutrophil migration and phagocytosis in the dog? | | 1990 | 2183577 |
| efficacy of granulocyte transfusions in the control of systemic candidiasis in the leukopenic host. | an experimental canine model was designed to evaluate the effect of granulocyte transfusions on systemic infection with candida albicans in the granulocytopenic host. each of a pair of dogs was rendered granulocytopenic with a single intravenous (i.v.) dose of cyclophosphamide (50 mg/kg body weight) and challenged with 10(6) candida albicans organisms administered i.v. when granulocyte counts were less than or equal to 500/mm3. granulocytes procured by leukofiltration were infused into six exper ... | 1978 | 678666 |