Publications

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american cutaneous leishmaniasis, lepromatous leprosy, and pulmonary tuberculosis coinfection with downregulation of the t-helper 1 cell response.cutaneous leishmaniasis, leprosy, and tuberculosis are caused by intracellular pathogens whose development depends on impaired cell-mediated immunity. we report an exceptional triple association of american cutaneous leishmaniasis, lepromatous leprosy, and pulmonary tuberculosis in a man with no recognized immunodeficiency. normal immunological assessment of the interferon-gamma pathway does not support the hypothesis of a genetic defect in any of the genes involved in the t helper (th)-1 cytoki ...200312942392
disseminated cutaneous leishmaniasis due to leishmania guyanensis: case of a patient with 425 lesions.disseminated cutaneous leishmaniasis is characterized by the presence of a large (> or =10) number of lesions at several anatomic sites (head, limbs, and trunk). most of the lesions are small, papular, and appear simultaneously with or secondarily to one or several ulcerated lesions of localized cutaneous leishmaniasis. we report the first case of disseminated cutaneous leishmaniasis in french guiana. it concerns a 24-year-old woman who tested negative for human immunodeficiency virus (hiv). the ...200415569784
Reproductive strategies and population structure in Leishmania: substantial amount of sex in Leishmania Viannia guyanensis.Leishmania species of the subgenus Viannia and especially Leishmania Viannia guyanensis are responsible for a large proportion of New World leishmaniasis cases. Since a recent publication on Leishmania Viannia braziliensis, the debate on the mode of reproduction of Leishmania parasites has been reopened. A predominant endogamic reproductive mode (mating with relatives), together with strong Wahlund effects (sampling of strains from heterogeneous subpopulations), was indeed evidenced. To determin ...201121722225
comparison of tetrazolium salt assays for evaluation of drug activity against leishmania spp.in french guiana, leishmaniasis is an essentially cutaneous infection. it constitutes a major public health problem, with a real incidence of 0.2 to 0.3%. leishmania guyanensis is the causal species most frequently encountered in french guiana. the treatment of leishmaniasis is essentially drug based, but the therapeutic compounds available have major side effects (e.g., liver damage and diabetes) and must be administered parenterally or are costly. the efficacy of some of these agents has decli ...201424719447
prevalence and distribution of leishmania rna virus 1 in leishmania parasites from french guiana.in south america, the presence of the leishmania rna virus type 1 (lrv1) was described in leishmania guyanensis and leishmania braziliensis strains. the aim of this study was to determine the prevalence distribution of lrv1 in leishmania isolates in french guiana given that, in this french overseas department, most leishmania infections are due to these parasite species. the presence of the virus was observed in 74% of leishmania spp. isolates, with a highest presence in the internal areas of th ...201626598572
leishmania spp. identification by polymerase chain reaction-restriction fragment length polymorphism analysis and its applications in french guiana.leishmania (viannia) guyanensis was for many years the only species commonly identified in french guiana, but precise species identifications were quite rare. we describe a new restriction fragment length polymorphism-polymerase chain reaction technique using a 615-bp fragment of the rna polymerase ii gene and 2 restriction enzymes, tspri and hgai. seven reference strains (leishmania (leishmania) amazonensis, leishmania (viannia) lainsoni, leishmania (viannia) braziliensis, l. (v.) guyanensis, l ...201019782495
phlebotomine sand flies (diptera: psychodidae) associated with changing patterns in the transmission of the human cutaneous leishmaniasis in french guiana.between march 2000 and december 2001 a survey of the sand flies (diptera: phlebotominae) of french guiana was carried out during 14 nights of captures with cdc light-traps and malaise traps, and resulted in the collection of 2245 individuals of 38 species. the most abundant species were lutzomyia (trichophoromyia) ininii floch & abonnenc, lu.(psychodopygus) squamiventris maripaensis floch & abonnenc, and lu .(nyssomyia) flaviscutellata mangabeira. half of the collected sand flies females were di ...200717293996
[outbreak of cutaneous leishmaniasis in military population coming back from french guiana].an outbreak of cutaneous leishmaniasis occurred among 71 soldiers who had participated in various missions during a 4-month's period in french guiana. the aims of this study were (i) to describe outbreak and (ii) to determine risk factors of cutaneous leishmaniasis.200616902382
molecular epidemiology of leishmania (viannia) guyanensis in french guiana.little information is available about the genetic variability of leishmania populations and the possible correlations with ecoepidemiological features of leishmaniases. the present study was carried out in french guiana, a country where cutaneous leishmaniases (cl) are endemic over the whole territory. the genetic polymorphism of a nuclear sequence encompassing the end of the ribosomal small subunit and the internal transcribed spacer 1 of 265 isolates from patients with cl was examined by restr ...200616455900
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