Publications

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experimental induction of proventricular dilatation disease in cockatiels (nymphicus hollandicus) inoculated with brain homogenates containing avian bornavirus 4.proventricular dilatation disease (pdd) is a fatal disorder of psittacine birds worldwide. the disease is characterized by lymphoplasmacytic infiltration of the central and peripheral nervous systems, leading to gastrointestinal motility and/or central nervous system dysfunction. recently, we detected a significant association between avian bornavirus (abv) infection and clinical signs of pdd in psittacines. however, it remains unclear whether abv infection actually causes pdd. to address this q ...200919589169
avian bornavirus associated with fatal disease in psittacine birds.thanks to new technologies which enable rapid and unbiased screening for viral nucleic acids in clinical specimens, an impressive number of previously unknown viruses have recently been discovered. two research groups independently identified a novel negative-strand rna virus, now designated avian bornavirus (abv), in parrots with proventricular dilatation disease (pdd), a severe lymphoplasmacytic ganglioneuritis of the gastrointestinal tract of psittacine birds that is frequently accompanied by ...201020219910
pathogenesis of avian bornavirus in experimentally infected cockatiels.avian bornavirus (abv) is the presumed causative agent of proventricular dilatation disease (pdd), a major fatal disease in psittacines. however, the influencing factors and pathogenesis of pdd are not known and natural abv infection exhibits remarkable variability. we investigated the course of infection in 18 cockatiels that were intracerebrally and intravenously inoculated with abv. a persistent abv infection developed in all 18 cockatiels, but, as in natural infection, clinical disease patte ...201222304809
no contact transmission of avian bornavirus in experimentally infected cockatiels (nymphicus hollandicus) and domestic canaries (serinus canaria forma domestica).avian bornaviruses (abv) are the causative agents of proventricular dilatation disease (pdd), a widely distributed disease of parrots. distinct abv lineages were also found in various non-psittacine avian species, such as canaries, but the pathogenic role of abv in these species is less clear. despite the wide distribution of abv in captive parrots and canaries, its mode of transmission is poorly understood: both horizontal transmission via the urofaecal-oral route and vertical transmission are ...201424933163
investigation of different infection routes of parrot bornavirus in cockatiels.the aim of this study was to determine the natural infection route of parrot bornavirus (pabv), the causative agent of proventricular dilatation disease (pdd) in psittacines. for this purpose, nine cockatiels ( nymphicus hollandicus ) were inoculated orally, and nine cockatiels were inoculated intranasally, with a pabv-4 isolate. to compare the results of the trials, the same isolate and the same experimental design were used as in a previous study where infection was successful by intravenous a ...201728301249
viral vector vaccines expressing nucleoprotein and phosphoprotein genes of avian bornaviruses ameliorate homologous challenge infections in cockatiels and common canaries.avian bornaviruses are causative agents of proventricular dilatation disease (pdd), an often fatal disease of parrots and related species (order psittaciformes) which is widely distributed in captive psittacine populations and may affect endangered species. here, we established a vaccination strategy employing two different well described viral vectors, namely recombinant newcastle disease virus (ndv) and modified vaccinia virus ankara (mva) that were engineered to express the phosphoprotein and ...201627830736
viral vector vaccines protect cockatiels from inflammatory lesions after heterologous parrot bornavirus 2 challenge infection.avian bornaviruses are causative agents of proventricular dilatation disease (pdd), a chronic neurologic and often fatal disorder of psittacines including endangered species. to date no causative therapy or immunoprophylaxis is available. our previous work has shown that viral vector vaccines can delay the course of homologous bornavirus challenge infections but failed to protect against pdd when persistent infection was not prevented. the goal of this study was to refine our avian bornavirus va ...201728017426
unusual and severe lesions of proventricular dilatation disease in cockatiels (nymphicus hollandicus) acting as healthy carriers of avian bornavirus (abv) and subsequently infected with a virulent strain of abv.a flock of 14 apparently healthy cockatiels, purchased from a single aviary, was tested for the presence of avian bornavirus (abv). twelve birds were found to be intermittently shedding abv, predominantly genotype 4. four of the cockatiels known to be shedding abv4 were subsequently challenged with the tissue culture derived, virulent m24 strain of abv4. the challenged birds remained in apparent good health until day 92 when one was found dead. the remaining three birds began to exhibit severe n ...201121331944
proventricular dilatation disease in cockatiels (nymphicus hollandicus) after infection with a genotype 2 avian bornavirus.an isolate of genotype 2 avian bornavirus (abv) was recovered from a cockatiel (nymphicus hollandicus) that was euthanatized for an unrelated lesion and showing no clinical evidence of proventricular dilatation disease (pdd). on histopathologic examination, mild inflammatory lesions were present in the heart and brain, but gastrointestinal lesions characteristic of classic pdd were not observed. to investigate if this abv2 isolate had reduced virulence, the virus was propagated in duck embryo fi ...201122216720
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