Publications

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risk factors of female hiv-seropositive patients attending the clinic for sexually transmitted diseases at st mary's hospital, london.of 3450 women tested for antibodies to human immunodeficiency virus hiv-1 and hiv-2 between september 1985 and july 1989, 61 were positive (1.8%). twenty-seven of these (44%) were presumed to have acquired their hiv infection by heterosexual contact and 23 (38%) were intravenous drug addicts. in geographical origin, 23 (38%) of the patients were from the uk and 19 (31%) from africa. amongst these 61 women, 2 (3%) have since died, one committed suicide and one was suspected of committing suicide.19902103742
aids vaccine study begins in england. 19892668833
needlestick injuries: how can we teach people better about risk assessment?at work people run some small risk of death or injury which is directly attributable to their occupation. in biomedical sciences the accidental puncture of the skin by hypodermic needles, other instruments or broken glass has long been regarded as an occupational hazard and there is increasing concern that staff could become infected with a range of micro-organisms, including hepatitis b and the human immunodeficiency virus (hiv). needlestick injuries should be preventable if staff are trained e ...19882907336
seroconversion of human t cell lymphotrophic virus iii (htlv-iii) in patients with haemophilia: a longitudinal study.patients with hemophilia are at a risk for the acquired immuno-deficiency syndrome (aids). as part of a surveillance program on aids, a group of patients with hemophilia was studied for clinical and immunological features associated with the syndrome. 30 patients in england who had received factor viii treatment within 5 years were studied. 29 (male) had hemophilia a, and 1 female heterozygote had been treated for postoperative bleeding. 1 man had been tattooed over 10 years previously. no ...19852988690
cum hastis sic clypeatis: the turbulent history of the condom.the recommendation of the surgeon general of the us public health service that individuals use the condom to prevent the risks of human immunodeficiency virus (hiv) infection and transmission has been poorly received. many oppose it on the basis of the perception that condoms would promote continued sexual activity when the solution to acquired immune deficiency syndrome (aids) is to discourage such activity. others raise questions about the efficacy of condoms in preventing hiv infection. fu ...19883069159
survey of general practitioners' attitudes to aids in the north west thames and east anglian regions.as the numbers of people suffering from human immunodeficiency virus infection and the acquired immune deficiency syndrome (aids) increase, so will the contribution to care required from general practice. a postal questionnaire survey was therefore carried out among general practitioners in the north west thames and east anglian regions to determine their attitudes to aids and the issues it raises for them. one hundred and thirty seven questionnaires were returned (response rate 57%) and four fa ...19883126898
involvement of multiple cryptococcus neoformans strains in a single episode of cryptococcosis and reinfection with novel strains in recurrent infection demonstrated by random amplification of polymorphic dna and dna fingerprinting.we compared the abilities of random amplification of polymorphic dna and dna fingerprinting, with oligonucleotide probes, to type five pairs of cryptococcus neoformans clinical isolates recovered from five separate human immunodeficiency virus-positive patients in london, england. the two techniques had comparable discriminatory abilities when applied to these isolates. a total of eight different isolate types were demonstrated in these patients. no isolate type was observed in more than one pat ...19957699075
hiv and the boundaries of confidentiality.confidentiality is an acknowledged duty of the nurse. it has foundations in ethics and has some legal force. there is also a more disingenuous reason for citing it as a duty: that it helps a group attain professional status. this may cause an over-zealous attitude towards confidentiality in some professionals. there are legal and ethical limits to confidentiality which can be seen clearly in cases which arise out of human immunodeficiency virus (hiv). whilst these make it clear that there are li ...19957897069
practice nurses: characteristics, workload and training needs.this study set out to identify the present and future training needs of practice nurses in south west thames regional health authority and to examine these needs within the nurses' current and changing workloads and social, educational and occupational profiles.19948312031
a clinico-pathological audit of opportunistic viral infections in hiv-infected patients.to determine the prevalence of opportunistic viral infections in multiple tissues at postmortems of hiv-infected patients, and to relate these findings to their antemortem clinical course.19938395189
computer assisted learning (cal) of oral manifestations of hiv disease.general dental practitioners (gdps) in the uk may wish additional education on relevant aspects of human immunodeficiency virus (hiv) disease. the aim of the present study was to develop and assess a computer assisted learning package on the oral manifestations of hiv disease of relevance to gdps. a package was developed using a commercially-available software development tool and assessed by a group of 75 gdps interested in education and computers. fifty-four (72%) of the gdps completed a self- ...19968854425
comparison of intestinal function in human immunodeficiency virus-seropositive patients in kampala and london.white homosexual men with human immunodeficiency virus (hiv) show progressive impairment of intestinal function assessed in terms of intestinal permeability and absorptive capacity. in this study we aimed to determine the effects of heterosexually acquired hiv on small-intestinal function in native africans, among whom there is a high prevalence of tropical enteropathy.199910423065
icu admission in patients infected with the human immunodeficiency virus - a multicentre survey.we conducted a retrospective study to assess the reasons for admission to the intensive care unit, and subsequent outcome, in patients infected with the human immunodeficiency virus (hiv). four hospitals in the south of england participated, all with specialist hiv units. data were collected on 127 patients admitted to icu on 133 separate occasions between june 1993 and october 1997. the mean age on admission was 38 years (range 23-60 years). ninety-four patients (70.7%) were documented hiv-posi ...199910460523
two simultaneous cases of cyclospora cayatensis enteritis returning from the dominican republic.according to the "international passenger survey," published in 1996 by the office of trading standards, 534,000 british people traveled to the caribbean area (personal communication, abta, 1998). the dominican republic, the eastern end of a large caribbean island, has become in recent years one of the most popular destinations for uk holidaymakers as well as for travelers from many other countries. cyclospora cayatensis has been firmly identified as a cause of gastroenteritis among internationa ...200010689243
herpes simplex virus infection of the central nervous system in human immunodeficiency virus-type 1-infected patients.we report clinical, radiological and virological data from nine consecutive hiv-infected patients with herpes simplex virus (hsv) infection of the central nervous system (cns). three patients presented with confusion, two with fever and headache, two with anxiety and depression, one with slow mentation and memory loss and one with expressive dysphasia. five patients had previous aids-defining diagnoses: four of these five patients had previous cutaneous hsv infection. hsv dna was detected by the ...200415339367
provision of safe potable water for immunocompromised patients in hospital.we conducted a survey of hospital drinking water provision for patients with immunocompromising conditions in 15 trusts in the north of england. ten trusts replied, reporting on provision of drinking water in 14 separate units. of these, nine provided only tap water to all patients, irrespective of underlying condition. in two units, iced water, with ice from commercially available makers, was used. five units distinguished between neutropenic and non-neutropenic patients, with the former group ...200415474188
advances in anti-viral therapeutics.hepatitis c virus (hcv) and hiv infections are of high economical importance as they have a global impact, high mortality rates and, consequently novel treatments are urgently needed. worldwide, 170 and 34 - 46 million people are infected with hcv and hiv, respectively. hcv and hiv medications constitute the largest antiviral markets today. the efforts in fighting hcv infections are still limited to early clinical development, trying to establish proof-of-concept in man. however, in hiv, there i ...200515833066
lymphogranuloma venereum in the united kingdom.over the past 2 years, lymphogranuloma venereum (lgv), caused by l serovars of chlamydia trachomatis, has emerged as a significant problem among men who have sex with men (msm). we report on, to our knowledge, the largest case series of lgv to date, with detailed epidemiological and clinical characteristics of the epidemic in the united kingdom.200717143811
increased rates of preterm delivery are associated with the initiation of highly active antiretrovial therapy during pregnancy: a single-center cohort study.it remains controversial whether in human immunodeficiency virus (hiv)-positive pregnant women an increased rate of preterm delivery is associated with highly active antiretroviral therapy (haart). since 1995 the management and outcome of all hiv-infected pregnant women delivering at st. mary's hospital london have been prospectively documented. the prevalence of preterm delivery and the correlation between gestational age and type of antiretroviral therapy were sought: preterm delivery occurred ...200717624841
investigating tuberculosis trends in england.to investigate the factors associated with the increasing incidence of tuberculosis in england.200818672258
loss to follow-up among adults attending human immunodeficiency virus services in england, wales, and northern ireland.: to assess the extent to which human immunodeficiency virus (hiv)-diagnosed adults attending hiv-services in england, wales, and northern ireland are lost to follow-up or attend services intermittently.201121844719
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