| Human Immunodeficiency Virus nef Signature Sequences are Associated with Pulmonary Hypertension. | Severe pulmonary hypertension (PH) associated with vascular remodeling is a long-term complication of HIV infection (HIV-PH) affecting 1/200 infected individuals vs. 1/200,000 frequency in the uninfected population. Factors accounting for increased PH susceptibility in HIV-infected individuals are unknown. Rhesus macaques infected with chimeric SHIVnef virions but not with SIV, display PH-like pulmonary vascular remodeling suggesting that HIV-Nef is associated with PH; these monkeys showed cha ... | 2011 | 22066947 |
| population genetic statistics from rhesus macaques (macaca mulatta) in three different housing configurations at the california national primate research center. | this study analyzed the genetic composition of 3382 genetically characterized and pedigreed animals currently maintained under 3 different housing configurations at the california national primate research center, including the indoor colony, outdoor 'corn cribs,' and half-acre field cages. summary statistics based on 15 short tandem repeats strongly suggest significant effects of genetic drift, including the loss of allele diversity, among the enclosures within the housing facilities even thoug ... | 2010 | 20858362 |
| association between hybrid status and reproductive success of captive male and female rhesus macaques (macaca mulatta) at the california national primate research center (cnprc). | the california national primate research center (cnprc) houses more than 1,000 rhesus macaques (macaca mulatta) of mixed chinese-indian ancestry. most of these animals are kept in outdoor field cages, the colony's long term breeding resource. since 2001, hybrids comprised between 4 and 49% of the field cage populations, but in most cases have represented a maximum of 10% of those populations. the increasing prevalence of hybrids is partly due to management efforts to distribute genetic diversity ... | 2011 | 21433046 |
| predictors of hemoglobin variability in a population of weaning age (3- to 4-month old) rhesus monkeys. | sources of variability in hemoglobin concentration in blood were examined in over 600 rhesus infants at the california national primate research center who had complete blood counts (cbcs) conducted at 3-4 months of age. these infants were born and raised in outdoor social housing. hemoglobin values ranged from 8.5 to 15.3 µg/dl with a mean and standard deviation of 12.2±0.8 µg/dl. as expected, hemoglobin was strongly associated with the number of red blood cells (rbcs). plasma protein concentra ... | 2013 | 23824639 |
| population genetics of the california national primate research center's (cnprc) captive callicebus cupreus colony. | the california national primate research center maintains a small colony of titi monkeys (callicebus cupreus) for behavioral studies. while short tandem repeat (str) markers are critical for the genetic management of the center's rhesus macaque (macaca mulatta) breeding colony, strs are not used for this purpose in the maintenance of the center's titi monkey colony. consequently, the genetic structure of this titi monkey population has not been characterized. a lack of highly informative genetic ... | 2015 | 25179309 |
| mitigating chinese-indian rhesus macaque (macaca mulatta) hybridity at the california national primate research center (cnprc). | the effectiveness of abating hybridity in a rhesus breeding colony was evaluated. str data from the 2006 to 2015 newborns were analyzed. hybridity decreased over successive years. birth cohorts retained high genetic variability without signs of inbreeding and differentiation. hybridity was minimized without compromising overall genetic variability. | 2016 | 27466971 |
| early life wildfire smoke exposure is associated with immune dysregulation and lung function decrements in adolescence. | the long-term health effects of wildfire smoke exposure in pediatric populations are not known. the objectives of this study were to determine if early life exposure to wildfire smoke can affect parameters of immunity and airway physiology that are detectable with maturity. we studied a mixed-sex cohort of rhesus macaque monkeys that were exposed as infants to ambient wood smoke from a series of northern california wildfires in the summer of 2008. peripheral blood mononuclear cells (pbmcs) and p ... | 2017 | 28208028 |
| class ii multiformity generated by variable mhc- drb region configurations in the california sea lion ( zalophus californianus). | in light of the immunological importance of molecules encoded within the major histocompatibility complex ( mhc), there are numerous studies examining the variability of these genes in wildlife populations. an underlying assumption in many of these studies is that mhc diversity invariably arises from a high level of allelic variation at a single gene locus, leading to widespread descriptions of thriving species with apparently limited mhc polymorphism. indeed, in a previous study we failed to fi ... | 2004 | 14997355 |
| the incidence of coccidioidomycosis among nonhuman primates housed outdoors at the california primate research center. | serum from 191 nonhuman primates housed outdoors from october 1977 to october 1978 at the california primate research center was assayed for the presence of antibody specific for coccidioidin. one macaca mulatta had coccidioidal antibody which was found to be associated with disseminated coccidioidomycosis. one macaca radiata had complement-fixing antibody specific for coccidioidin and a pulmonary lesion. additionally, two other animals had coccidioidal antibody but lacked clinical evidence of d ... | 1980 | 6775083 |
| Hepatitis e virus in rats, los angeles, california, USA. | The role of rats in human hepatitis E virus (HEV) infections remains controversial. A genetically distinct HEV was recently isolated from rats in Germany, and its genome was sequenced. We have isolated a genetically similar HEV from urban rats in Los Angeles, California, USA, and characterized its ability to infect laboratory rats and nonhuman primates. Two strains of HEV were isolated from serum samples of 134 wild rats that had a seroprevalence of antibodies against HEV of ˜80%. Virus was tran ... | 2011 | 22172320 |
| genetic characterization of specific pathogen-free rhesus macaque (macaca mulatta) populations at the california national primate research center (cnprc). | a study based on 14 strs was conducted to understand intergenerational genetic changes that have occurred within the california national primate research center's (cnprc) regular specific pathogen-free (spf) and super-spf captive rhesus macaque populations relative to their conventional founders. intergenerational genetic drift has caused age cohorts of each study population, especially within the conventional population, to become increasingly differentiated from each other and from their found ... | 2010 | 20162538 |
| frequency of spontaneous congenital defects in rhesus and cynomolgus macaques. | this paper summarizes the spontaneous incidence of congenital defects in the rhesus and cynomolgus macaque colonies (macaca mulatta and m. fascicularis) at the california regional primate research center. the computerized database used in this analysis included fetuses, term infants, juveniles, and adults that underwent a necropsy procedure over a 14-year period (1983-1996). the calculated malformation rates were 0.9% (40/4,390) and 0.3% (3/965) for the rhesus and cynomolgus monkey, respectively ... | 1997 | 9437266 |
| origins of simian immunodeficiency virus infection in macaques at the new england regional primate research center. | a cohort of rhesus macaques (macaca mulatta), obtained from the california regional primate research center (crprc) and necropsied in 1970-72 with lesions suggestive of simian immunodeficiency virus (siv) infection, was identified at the new england regional primate research center (nerprc). polymerase chain reaction (pcr), dna sequence analysis, and in situ hybridization were used to confirm the presence of siv nucleic acids. this represents the earliest case of siv infection at the nerprc and ... | 1995 | 8751050 |
| the pathology of an epizootic of acquired immunodeficiency in rhesus macaques. | a syndrome of acquired immunodeficiency within a group of outdoor-housed rhesus macaques (macaca mulatta) with unusually high mortality has been identified at the california primate research center. the cause of death for most of the affected animals included septicemia and/or chronic diarrhea with wasting, often complicated by other problems. in many cases, multiple or unusual infectious agents were isolated or recognized, including cytomegalovirus, cryptosporidium spp., and candida albicans. s ... | 1984 | 6691418 |
| clinical features of simian acquired immunodeficiency syndrome (saids) in rhesus monkeys. | a syndrome of acquired immunodeficiency has been identified in a group of rhesus monkeys (macaca mulatta) which died at the california primate research center. clinical evaluation of these animals revealed that 50% or more had lymphadenopathy, weight loss, and diarrhea. at least 30% had splenomegaly, fever, cutaneous abscesses and/or arthritis/myositis. two animals had fibrosarcomas. anemia was seen in 19 animals, lymphopenia in 14, granulocytopenia in four and thrombocytopenia in three. hepatit ... | 1984 | 6328113 |
| epidemic of acquired immunodeficiency in rhesus monkeys. | a syndrome closely resembling acquired immunodeficiency syndrome (aids) in man has been identified in a group of 64 rhesus monkeys (macaca mulatta) maintained outdoors at the california primate research center. the syndrome is characterised by generalised lymphadenopathy, severe opportunistic infections including cytomegalovirus, chronic wasting, and high mortality. in 1 animal a multifocal cutaneous fibrosarcoma developed. this syndrome in monkeys may provide an animal model for human aids. | 1983 | 6130381 |
| infant mortality in macaca mulatta: neonatal and post-neonatal mortality at the california primate research center, 1968-1972. a retrospective study. | seven hundred forty-two macaca mulatta births were recorded at the california primate research center, 1968-1972. the neonatal mortality rate (deaths smaller than or equal to 30 days of age) was 10.8%, and the post-neonatal mortality rate (deaths at 31-183 days) was 6.9%. the neonatal mortality rate was higher in outdoor group cages than in indoor individual cages (24.8 vs. 8.0%). the post-neonatal mortality rate was also higher outdoors than indoors (15.9 vs. 5.9%). outdoor mortality showed app ... | 1975 | 1123839 |
| a large-scale snp-based genomic admixture analysis of the captive rhesus macaque colony at the california national primate research center. | some breeding facilities in the united states have crossbred chinese and indian rhesus macaque (macaca mulatta) founders either purposefully or inadvertently. genetic variation that reflects geographic origins among research subjects has the potential to influence experimental outcomes. the use of animals from different geographic regions, their hybrids, and animals of varying degrees of kinship in an experiment can obscure treatment effects under study because high interanimal genetic variance ... | 2012 | 24436199 |
| contribution of endemic listeriosis to spontaneous abortion and stillbirth in a large outdoor-housed colony of rhesus macaques (macaca mulatta). | listeria monocytogenes is an endemic agent in the primate population at the california national primate research center and has been associated with both sporadic cases and a general outbreak of pregnancy failures. the primary objective of this study was to verify the incidence of l. monocytogenes-associated abortion and fetal deaths in the center's outdoor breeding colony. in addition, we sought to compare the group of female macaques that presented with listeria-associated abortion with both t ... | 2015 | 26224440 |