Publications

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green tea intake, ace gene polymorphism and breast cancer risk among chinese women in singapore.experimental and epidemiological data have implicated a potential chemoprotective role of green tea polyphenols and a potential enhancing role of angiotensin ii in the development of breast cancer in humans. angiotensin ii is converted from its precursor by angiotensin-converting enzyme (ace). women with low-activity genotype of the ace gene had a reduced risk of breast cancer compared with those possessing high-activity ace genotype. experimental data showed that green tea polyphenols could inh ...200515802301
green tea and black tea consumption in relation to colorectal cancer risk: the singapore chinese health study.the relationships between green tea and black tea consumption and colorectal cancer risk were examined within the singapore chinese health study, a prospective cohort study of diet and cancer involving >60,000 men and women. intake of green tea and black tea was assessed through in-person interviews. incident cancer cases and deaths among cohort members were identified through record linkage of the cohort database with respective databases from the nationwide singapore cancer registry and the si ...200717724377
coffee, tea, and incident type 2 diabetes: the singapore chinese health study.increasing coffee intake was inversely associated with risk of type 2 diabetes in populations of european descent; however, data from high-risk asian populations are lacking as are data on tea intake in general.200818842784
green tea, soy, and mammographic density in singapore chinese women.there is increasing evidence from observational studies that breast cancer risk is inversely associated with soy and green tea consumption. we investigated the effects of these two dietary agents on mammographic density, a well-established biomarker for breast cancer risk, in a cross-sectional analysis of mammograms and validated food frequency questionnaires from 3,315 chinese women in singapore. percent mammographic density (pmd) was assessed using a reproducible computer-assisted method. we u ...200819064551
green and black tea intake in relation to prostate cancer risk among singapore chinese.tea is one of the most commonly consumed beverages worldwide. to date, observational data from prospective cohort studies investigating the relationship between green and black tea intake and prostate cancer risk are sparse and equivocal. in a population-based, prospective cohort study of chinese men in singapore, we investigated the relationship between green and black tea intake and prostate cancer risk.201222864870
serum urate levels and consumption of common beverages and alcohol among chinese in singapore.western studies suggest that beverages may affect serum urate (su) levels, but data from asian populations are scarce. we evaluated the associations between beverages and su levels in singaporean chinese.201323463601
coffee, alcohol and other beverages in relation to cirrhosis mortality: the singapore chinese health study.limited experimental and epidemiologic data suggest that coffee may reduce hepatic damage in chronic liver disease. the association between consumption of coffee and other beverages and risk of cirrhosis mortality was evaluated in the singapore chinese health study. this is a prospective population-based cohort of 63,275 middle-aged and older chinese subjects who provided data on diet, lifestyle, and medical histories through in-person interviews using a structured questionnaire at enrollment be ...201424753005
coffee and tea consumption in relation to inflammation and basal glucose metabolism in a multi-ethnic asian population: a cross-sectional study.abstract: background: higher coffee consumption has been associated with a lower risk of type 2 diabetes in cohort studies, but the physiological pathways through which coffee affects glucose metabolism are not fully understood. the aim of this study was to evaluate the associations between habitual coffee and tea consumption and glucose metabolism in a multi-ethnic asian population and possible mediation by inflammation. methods we cross-sectionally examined the association between coffee, gree ...201121631956
tea consumption and cognitive impairment and decline in older chinese adults.laboratory research suggests that tea has potential neurocognitive protective effects, but this is not established in humans.200818614745
differential effects of black versus green tea on risk of parkinson's disease in the singapore chinese health study.data from asian populations on dietary and lifestyle factors associated with parkinson's disease are sparse. in 1993-2005, the authors examined these factors in relation to parkinson's disease in the singapore chinese health study, a prospective cohort of 63,257 chinese men and women. baseline data were collected through in-person interviews using structured questionnaires. all 157 incident parkinson's disease cases were identified either through follow-up interviews or via linkage with hospital ...200818156141
tea and circulating estrogen levels in postmenopausal chinese women in singapore.the role of tea in the etiology of breast cancer is controversial. we recently provided the first set of human evidence that breast cancer risk is significantly inversely associated with tea intake, largely confined to intake of green tea. since black tea and green tea possess comparable levels of the total tea polyphenols that possess antioxidative activities, reasons for the paradoxical effects of green tea and black tea on breast cancer protection are not apparent. some limited evidence sugge ...200515661801
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