| hepatitis c virus serotype-specific core and ns4 antibodies in injecting drug users participating in the amsterdam cohort studies. | in the present study, the riba hcv serotyping sia was evaluated with a cohort of injecting drug users. serotyping may be a rapid and cost-effective method of determining genotypes in cohort studies. in this study, hepatitis c virus (hcv) antibody-positive sera from a cohort of 331 chronically infected injecting drug users, of which 167 were coinfected with human immunodeficiency virus (hiv), were serotyped by the riba hcv serotyping sia. among the 331 specimens, serotype-specific antibodies were ... | 1998 | 9738057 |
| risk factors for human herpesvirus 8 infection in a cohort of drug users in the netherlands, 1985-1996. | to elucidate the mode of human herpesvirus 8 (hhv-8) transmission in a population of amsterdam drug users, hhv-8 seroprevalence and seroincidence were determined in 1179 drug users in the amsterdam cohort studies (1985-1996). risk factors for hhv-8 infection were examined. serum samples were screened with an enzyme immunoassay by using hhv-8 lytic capsid (open-reading frame [orf] 65) and latent nuclear (orf73) antigens; positive results were confirmed by western blot and immunofluorescence assay ... | 2002 | 12085330 |
| changes in risk behavior and dynamics of hepatitis c virus infections among young drug users in amsterdam, the netherlands. | to elucidate the character and magnitude of the hepatitis c virus (hcv) epidemic among drug users in amsterdam, 197 young drug users from the period 2000 to 2004 were compared with 215 counterparts from 1985 to 1989. although injection risk behavior and hcv seroprevalence decreased sharply over time, hcv seroprevalence remains high (44%) among young drug users who have ever injected. phylogenetic analysis shows that current hcv infections originate from diversification of strains already circula ... | 2005 | 16254983 |
| increase in hcv incidence among men who have sex with men in amsterdam most likely caused by sexual transmission. | we retrospectively screened 1836 men who have sex with men (msm) participating in the amsterdam cohort studies (1984-2003) for hepatitis c virus (hcv) antibodies. hcv incidence was 0.18/100 person-years (py) in human immunodeficiency virus (hiv)-positive msm (8/4408 py [95% confidence interval {ci}, 0.08-0.36]) but was 0/100 py in msm without hiv (0/7807 py [95% ci, 0.00-0.05]). after 2000, hcv incidence among hiv-positive men increased 10-fold to 0.87/100 py (5/572 py [95% ci, 0.28-2.03]). addi ... | 2007 | 17570110 |
| never injected, but hepatitis c virus-infected: a study among self-declared never-injecting drug users from the amsterdam cohort studies. | the aim of this study was to gain insight in transmission routes of hepatitis c virus (hcv) infection among never-injecting drug users (du) by studying, incidence, prevalence, determinants and molecular epidemiology of hcv infection. from the amsterdam cohort studies among du, 352 never-injecting du were longitudinally tested for hcv antibodies. logistic regression was used to identify factors associated with antibody prevalence. part of hcv ns5b was sequenced to determine hcv genotype and for p ... | 2009 | 19243497 |
| hepatitis c virus infections among hiv-infected men who have sex with men: an expanding epidemic. | since 2000 outbreaks of sexually transmitted hepatitis c virus (hcv) infections have been reported among hiv-infected men who have sex with men (msm). we studied the prevalence and determinants of hcv-infection among msm attending a large sexually transmitted infection (sti) clinic in the netherlands. | 2009 | 19542864 |
| frequent hcv reinfection and superinfection in a cohort of injecting drug users in amsterdam. | this study investigates the occurrence of hcv reinfection and superinfection among hcv seroconverters participating in the amsterdam cohort studies among drug users from 1985 through 2005. | 2009 | 19646773 |
| emergence of hepatitis c virus genotype 4: phylogenetic analysis reveals three distinct epidemiological profiles. | hepatitis c virus (hcv) genotype 4 (hcv-4) infection is considered to be difficult to treat and has become increasingly prevalent in european countries, including the netherlands. using a molecular epidemiological approach, the present study investigates the genetic diversity and evolutionary origin of hcv-4 in amsterdam, the netherlands. phylogenetic analysis of the ns5b sequences (668 bp) obtained from 133 patients newly diagnosed with hcv-4 infection over the period from 1999 to 2008 revealed ... | 2009 | 19794040 |
| hepatitis c testing and treatment among active drug users in amsterdam: results from the dutch-c project. | although hepatitis c virus (hcv) treatment has shown to be effective, uptake of treatment among active drug users is still low. the drug users treatment for chronic hepatitis-c project aims to offer active drug users in amsterdam hcv testing and treatment using a multidisciplinary approach. | 2011 | 21042221 |
| alarming incidence of hepatitis c virus re-infection after treatment of sexually acquired acute hepatitis c virus infection in hiv-infected msm. | recent data indicate that seroprevalence of sexually transmitted hepatitis c virus (hcv) infection among msm is stabilizing in amsterdam. however, little is known about the incidence of hcv re-infection in msm who have cleared their hcv infection. we, therefore, studied the incidence of re-infection in hiv-infected msm who were hcv rna-negative following hcv treatment of acute primary infection. | 2011 | 21857492 |