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phylogenetic tree-based epidemiological analysis of hepatitis c virus transmission in a region of japan with a high prevalence of infection.local clustering of hepatitis c virus (hcv) infection has been demonstrated in various regions in japan. hcv genotypes have now been compared between infected individuals from districts of saga prefecture with either a high (h district) or low (l district) prevalence of hcv-seropositivity. the prevalence of hcv genotype 1b was significantly higher (p < 0.001) in the h district (45/50; 90%) than in the l district (19/36; 52.8%). a phylogenetic tree was constructed based on the genomic sequences o ...19968840239
[clinical investigation of hcv antibodies positive cases in the district with high mortality rate of liver diseases in saga prefecture].the mortality and morbidity rates of chronic liver disease (cld) have been extremely high for several years at saga prefecture in japan. epidemiological studied revealed districts with high mortality rate of cld (h-district). we measured c 100-3ab and hcvcoreab (coreab) in the h-district and observed high discrepancy between c100-3 and coreab. in order to examine pathogenesis of this discrepancy, we determined serum hcvrna in these cases. the positive cases of hcv-ab among 459 subjects were 33.6 ...19938390393
[epidemiological study of anti-hcv antibodies in saga district]. 19911849197
prevalence of chronic liver diseases and anti-hcv antibodies in different districts of saga, japan.the authors examined the contribution of hepatitis c virus (hcv) to the morbidity of chronic liver diseases (cld) in selected districts of saga, japan, one group with low (l) and the other with a high (h) mortality rate of cld. age and sex-matched epidemiological studies showed an extremely high morbidity of cld in the h-district (5.3%) and a low one in the l-districts (2.1%). randomized selected studies of anti-hcv antibodies showed an extremely high frequency of 10.8% in the h-district and a f ...19911645685
overlap and discrepancy between tests for anti-c100, anti-gor and anti-cp9 in patients with chronic liver disease and inhabitants in saga, japan.the authors evaluated the clinical significance of anti-c100, anti-gor and anti-cp9 in hepatitis c virus (hcv)-related liver disease in two populations: 459 healthy subjects and 385 patients with chronic liver disease (cld). previously we reported high rates of mortality and morbidity (5.3%) of cld in subjects in saga, japan. this was ascribed to the high prevalence (10.8%) of anti-hcv among randomized populations, as detected by the c100 elisa test system, as compared with a finding of 2-3% in ...19921382031
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