| prevalence, genotypes, and an isolate (hc-c2) of hepatitis c virus in chinese patients with liver disease. | china has not been extensively investigated for the prevalence of hepatitis c virus (hcv) infection among people with or without liver disease. we analyzed serum from 2,177 liver disease patients from 7 cities in different areas of china. of 435 acute hepatitis patients, only 11% were positive for hcv rna, while hepatitis b surface antigen (hbsag) was detected in 33%. of 1,668 patients with chronic liver disease, 14% and 74% were positive for hcv rna and hbsag, respectively. nearly 80% of non-b ... | 1993 | 8394876 |
| virological features of hepatitis c virus infection in patients with liver diseases in the inshore area of the yangtze river. | the prevalence, genotypes, coinfection and putative core gene sequence of hepatitis c virus (hcv) were investigated in the inshore area of the yangtze river, where hepatocellular carcinoma (hcc) is thought to be very common. most patients with liver diseases were infected with hepatitis b virus (hbv), but the incidence of anti-hcv was very low, being 3.4% in patients with acute hepatitis, and approximately 7% in those with chronic liver diseases. the rate of coinfection with hbv and hcv in patie ... | 1994 | 7524191 |
| hepatitis c virus rna and antibodies among blood donors in beijing. | blood units from voluntary as well as commercial donors in beijing, china, were tested for hepatitis c virus rna and antibodies, and for serological markers of hepatitis b virus infection. hcv rna was detected less frequently in 1909 voluntary donors (5 (0.3%)), than in 1017 commercial donors (58 (5.7%)) (p < 0.001). antibody to hepatitis c virus was detected by the second-generation enzyme immunoassay in 55 (87%) of 63 blood units with viremia. evidence of present or past infection with hepatit ... | 1994 | 7529274 |
| a new molecular simulation software package--peking university drug design system (pkudds) for structure-based drug design. | we present a comprehensive molecular simulation program package, the peking university drug design system (pkudds), which runs on personal computers. pkudds has been developed mainly for computer-aided drug design using the methods of two-dimensional quantitative structure-activity relationships, three-dimensional quantitative structure-activity relationships, molecular docking, and database screening. this study presents an overview of its functionality, especially of methods developed in our g ... | 2001 | 11552694 |
| infection with gb virus c and hepatitis c virus in hemodialysis patients and blood donors in beijing. | rnas of gb virus c (gbv-c) and hepatitis c virus (hcv) were sought by reverse-transcription polymerase chain reaction with nested primers deduced from the 5' untranslated region: 79 patients on maintenance hemodialysis, 205 commercial blood donors, and 205 voluntary donors in beijing were studied. gbv-c rna was detected in 43 (54%) patients and 17 (8%) commercial donors, and hcv rna in 43 (54%) patients and 13 (6%) commercial donors, respectively. by contrast, gbv-c rna was detected only in 2 (1 ... | 1997 | 9131454 |
| hcv subtype characterization among injection drug users: implication for a crucial role of zhenjiang in hcv transmission in china. | hcv transmission is closely associated with drug-trafficking routes in china. however, the transmission route of hcv in eastern china remains unclear. here, we investigate the role of zhenjiang city of jiangsu province, an important transportation hub linking shanghai with other regions of china, in hcv transmission. | 2011 | 21304823 |
| [study on the epidemiology and distribution of human immunodeficiency virus-1 and hepatitis c virus infection among intravenous drug users and illegal blood donors in china]. | to determine the epidemiologic features and distribution of human immunodeficiency virus-1 (hiv-1) and hepatitis c virus (hcv) infection among intravenous drug users and illegal blood donors in china. | 2003 | 14687492 |
| [a prevalence study on hepatitis c infection in 4,055 healthy children of beijing]. | to understand the prevalence of hepatitis c (hc) infection in children of urban beijing. | 1999 | 11864475 |
| double-antigen sandwich elisa for the detection of anti-hepatitis c virus antibodies. | a double-antigen sandwich elisa was developed a detection of hcv antibodies by a recombinant multi-epitope hcv antigen and a biotin-streptavidin amplification system. three plasma specimens from 1708 individuals who were suspected previously to be hcv-positive using an hcv antibody diagnostic kit (chuangxin, xiamen, china) displayed negative results when using the elisa. these results were validated by a recombinant immunoblotting assay (two were negative, and one was indeterminate). among 889 b ... | 2010 | 21029749 |
| [investigation of anti-hepatitis c virus in the sera of different populations of beijing]. | a study of anti-hcv in the sera of different populations of beijing was conducted. of the general population, 2.1% (9/438) were anti-hcv positive, and of the patients that underwent blood transfusion 11.1% (6/54) were anti-hcv positive. among patients with chronic liver diseases, anti-hcv was positive in 10.5% (36/342) of patients with chronic persistent hepatitis (cph), 12.1% (13/107) of those with chronic active hepatitis (cah), 42.6% (63/148) of those with liver cirrhosis (lc) and 38.4% (20/5 ... | 1992 | 1374286 |
| [analysis of hiv/syphilis/hcv infection among drug users in 15 cities, china]. | to study the hiv infection rate and relevant behavioural characteristics among drug users (dus) in the 15 cities of china-gates hiv/aids program. | 2010 | 21215121 |