Publications

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evaluation and optimization of membrane feeding compared to direct feeding as an assay for infectivity.malaria parasite infectivity to mosquitoes has been measured in a variety of ways and setting, includind direct feeds of and/or membrane feeding blood collected from randomly selected or gametocytemic volunteers. anopheles gambiae s.l is the main vector responsible of plasmodium falciparum transmission in bancoumana and represents about 90% of the laboratory findings, whereas plasmodium malariae and plasmodium ovale together represent only 10%.200819055715
intermittent preventive treatment of malaria provides substantial protection against malaria in children already protected by an insecticide-treated bednet in mali: a randomised, double-blind, placebo-controlled trial.previous studies have shown that in areas of seasonal malaria transmission, intermittent preventive treatment of malaria in children (iptc), targeting the transmission season, reduces the incidence of clinical malaria. however, these studies were conducted in communities with low coverage with insecticide-treated nets (itns). whether iptc provides additional protection to children sleeping under an itn has not been established.201121304923
Prevalence of maternal and placental malaria and of neonatal low birth weight in a semi-urban area of Bamako (Mali).In 2006, the Malian government established a program for free insecticide-treated net (ITNs) distribution during antenatal care visit (ANC) and intermittent preventive treatment during pregnancy with sulfadoxine-pyrimethamine (IPTp-SP) for pregnant women. In March to November of 2009, we conducted a cross-sectional study in peri-urban areas of Bamako, Mali to determine the malaria prevalence among pregnant women and their newborn children in the context of this policy. We included 379-ápregnant ...201121700554
baseline in vitro efficacy of act component drugs on plasmodium falciparum clinical isolates from mali.in vitro susceptibility to antimalarial drugs of malian plasmodium falciparum isolates collected between 2004 and 2006 was studied. susceptibility to chloroquine and to three artemisinin-based combination therapy (act) component drugs was assessed as a first, to our knowledge, in vitro susceptibility study in mali. overall 96 malian isolates (51 from around bamako and 45 collected from french travellers returning from mali) were cultivated in a co(2) incubator. fifty percent inhibitory concentra ...200818249407
[assessment of chloroquine resistance two years after stopping chemoprophylaxis in 0 to 9-year-old children living in a malaria-endemic village of mali].this study was carried out in the village of faladié, mali located in the malaria-endemic kati region, two years after routine use of chloroquine prophylaxis was discontinued in children 0 to 9 years old. the main purpose of this study was to assess changes in chloroquine resistance. two cross-sectional surveys in association with who in vivo chloroquine sensitivity testing were conducted, i.e., one in september 2000 and one in december 2002. findings in 2000 showed that 77.5% of mothers adminis ...200415771023
perspectives of people in mali toward genetically-modified mosquitoes for malaria control.genetically-modified (gm) mosquitoes have been proposed as part of an integrated vector control strategy for malaria control. public acceptance is essential prior to field trials, particularly since mosquitoes are a vector of human disease and genetically modified organisms (gmos) face strong scepticism in developed and developing nations. despite this, in sub-saharan africa, where the gm mosquito effort is primarily directed, very little data is available on perspectives to gmos. here, results ...201020470410
[systematic search for parasites among leprosy patients in mali].practice of multidrug therapy in leprosy (combination dapsone + rifampicine + clofazimine) established since 1981, has significantly reduced the incidence of the disease. however, immunosuppression due to treatment of multi-drugs therapy induced adverse reactions with glucocorticoid and the change in host immune response due to the leprosy itself, might increase the risk of parasitic infections. to test this hypothesis, we carried out a case-control study at the "institut marchoux" in bamako. st ...200212616942
alleles 308a and 238a in the tumor necrosis factor alpha gene promoter do not increase the risk of severe malaria in children with plasmodium falciparum infection in mali.the hypothesis that tumor necrosis factor (tnf) aggravates malaria in children is supported by observations that tnf polymorphisms and high tnf levels have been associated with cerebral malaria. nevertheless, severe malaria was not associated with polymorphisms located at positions -308a and -238a in the tnf alpha gene promoter or with a high tnf level in plasma in children from bamako, mali.200616982833
determinants of anemia among pregnant women in mali.anemia in pregnancy remains a major problem in nearly all developing and many industrialized countries. in mali, the subpopulation prevalence and etiology of anemia during pregnancy are largely unknown.200616572713
gametocyte infectivity by direct mosquito feeds in an area of seasonal malaria transmission: implications for bancoumana, mali as a transmission-blocking vaccine site.infectivity of gametocytemic volunteers living in bancoumana, a village 60 km from bamako, mali, was determined by direct feeds of laboratory-reared anopheles gambiae s. l. gametocytemic adolescents (10-18 years old) were as infectious to mosquitoes as younger volunteers and appear to be a more suitable population for testing transmission-blocking efficacy as compared with adults (> 18 years old). to begin to validate the membrane-feeding assay, sera collected from these same volunteers were sub ...19989749648
a high malaria reinfection rate in children and young adults living under a low entomological inoculation rate in a periurban area of bamako, mali.in areas of intense malaria parasite transmission, preliminary studies of the rate of reinfection after curative therapy suggest that small sample size studies of vaccine efficacy are feasible. however, the effect of transmission rate, which may vary considerably between transmission seasons, on reinfection rate has not been assessed in areas of mesoendemicity with seasonal transmission. to address this question, the plasmodium falciparum reinfection rate after curative therapy was measured in s ...200212139226
natural polymorphism in the thrombospondin-related adhesive protein of plasmodium falciparum.we have developed a typing system using natural sequence variation in the thrombospondin-related adhesive protein (trap) gene of plasmodium falciparum. this method permits a haplotype to be assigned to any particular trap gene. we have applied this method to a hospital-based, case control-study in mali. previous sequence variation and conservation in trap has been confirmed. particular trap haplotypes can be used as geographic hallmarks. because of the high level of conflict between characters, ...19989452297
[in vivo sensitivity of plasmodium falciparum to chloroquine in bamako (the republic of mali)]. 19863531795
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