Publications

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malaria transmission in a region of savanna-forest mosaic, haut-ogooué, gabon.during the 2 years 1993 to 1995, an entomological survey was carried out in the savanna-forest area of franceville, gabon, investigating malaria transmission in one suburban district of franceville (akou) and in one rural village (benguia). the biting rates of the anopheles vectors were 10 times higher in the rural zone compared to the suburban zone. anopheles funestus giles was the predominant species in both zones followed by anopheles gambiae s.l. giles. the densities of anopheles nili theoba ...199910342264
molecular analysis of dhfr and dhps genes in p. falciparum clinical isolates from the haut--ogooué region in gabon.the main objective of this work was to determine the prevalence of mutations in genes coding for the dihydropteroate synthase (dhps) and the dihydrofolate reductase (dhfr) enzymes which are implicated in resistance of p. falciparum to antifolate (pyrimethamine-sulfadoxine (p/s)). in this study, 117 human blood samples were collected at franceville located in the region of haut-ogooué (south-eastern gabon). in this area, a relatively low level of sensitivity of plasmodium falciparum to p/s has be ...200111311186
in vitro susceptibility to a new antimalarial organometallic analogue, ferroquine, of plasmodium falciparum isolates from the haut-ogooué region of gabon.to assess the activity of a new organometallic chloroquine analogue, ferroquine, against numerous plasmodium falciparum isolates from gabon.200312654770
in vitro antiplasmodial activity and cytotoxicity of nine plants traditionally used in gabon.as part of a project to identify new compounds active on malarial parasites, we tested the in vitro antiplasmodial activity of nine plants traditionally used to treat malaria symptoms in haut-ogooué province, south-east gabon.201021134437
in vitro activity of chloroquine, quinine, mefloquine and halofantrine against gabonese isolates of plasmodium falciparum.to determine the in vitro activity of antimalarial drugs against isolates of plasmodium falciparum in gabon.200312535246
lack of malaria parasite transmission between apes and humans in gabon.the international center for medical research (cirmf) is located in an area highly endemic for malaria in southeastern gabon, where humans and apes (gorillas and chimpanzees) are living in the same geographic area. the presence of the cirmf primate center housing apes (59 chimpanzees and nine gorillas in 1994) within the city of franceville provided an opportunity to investigate the capability of cross-transmission of malaria species from humans to apes. the main vector of human malaria, anophel ...19979158055
placental pathologic changes in malaria. a histologic and ultrastructural study.placenta malarial changes (pmcs) related to maternal plasmodium infection were present in 33% (247 cases) of a series of 741 placentas collected from an unselected population living in an area of high malarial endemicity (haut-ogooué, gabon, africa). plasmodia were found on material thick blood films taken at the time of delivery in 42% of the women with and 24% of women without associated pmcs. plasmodium falciparum was the most frequent infecting organism. pmcs were more frequent and, in gener ...19826758604
natural antibodies against three distinct and defined antigens of plasmodium falciparum in residents of a mesoendemic area in gabon.the magnitude of the antibody response to three distinct and defined antigens of plasmodium falciparum was assessed in 144 inhabitants of the kassa district (haut ogooué province, gabon), a region where malaria is mesoendemic. antibodies against a polypeptide consisting of 40 (asn-ala-asn-pro) repeats of p. falciparum circumsporozoite protein [(nanp)40] were detected by elisa. antibodies against the fusion peptide 31.1, which consists of the n-terminal portion of the 190-200 kda glycoprotein, we ...19883044153
age-related prevalence of antibody response against three different, defined plasmodium falciparum antigens in children from the haut-ogooué province in gabon.the kinetics of the humoral response to defined plasmodium falciparum antigens was studied in 543 children, 1 month to 15 years old, living in an area endemic for malaria. the antigens used for enzyme-linked immunosorbent assay were (i) the synthetic peptide (nanp)40 representing the immunodominant repeated region of the circumsporozoite protein, and (ii) the fusion peptide 31.1, representing the n-terminal portion of the 83 kda polypeptide expressed at the surface of merozoites which is a proce ...19892692217
[epidemiologic aspects of malaria in gabon].the authors report the results of 3 sample surveys carried out in libreville, ngounié and haut-ogooué provinces to evaluate the main malarial indexes among 0 to 15 years old children in gabon. these investigations would suggest that malaria is mesoendemic in the three areas. the systematic presumptive antimarial treatment of fever attacks is widely used in libreville but not so frequent in rural areas.19902195284
In vitro antiplasmodial activity and cytotoxicity of extracts and fractions of Vitex madiensis, medicinal plant of Gabon.Vitex madiensis Oliv. (Lamiaceae) is traditionally used to treat malaria symptoms in Haut-Ogooué, Gabon. Leaves and stem barks extracts were obtained using dichloromethane (CH(2) Cl(2) ), ethyl acetate (EtOAc) and methanol (MeOH) as extraction solvents and fractionated on silica gel column. The in vitro antiplasmodial activity of CH(2) Cl(2) , EtOAc and MeOH extracts and fractions was evaluated against the chloroquine-resistant FCB strain and field isolates of Plasmodium falciparum using the DEL ...201122141406
increased prevalence of the plasmodium falciparum pfmdr1 86n genotype among field isolates from franceville, gabon after replacement of chloroquine by artemether-lumefantrine and artesunate-mefloquine.despite global antimalarial measures, plasmodium falciparum malaria remains a major public health problem. who has recommended the use of arteminisin-based combination therapy to limit the emergence of antimalarial drug resistance. however, act treatment failures have been linked to the selection of the wild types 86n genotype of p. falciparum multidrug resistance 1 (pfmdr1) and the 76k genotype of p. falciparum chloroquine resistance (pfcrt) genes. the aim of this study was to investigate the m ...201121251998
cytoadherence and genotype of plasmodium falciparum strains from symptomatic children in franceville, southeastern gabon.plasmodium falciparum causes severe clinical manifestations by sequestering parasitized red blood cells (prbc) in the microvasculature of major organs such as the brain. this sequestration results from prbc adherence to vascular endothelial cells via erythrocyte membrane protein 1, a variant parasite surface antigen.200717607045
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