| mutations in plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in senegal. | senegal recently (2004) switched to sulfadoxine-pyrimethamine (sp) with amodiaquine as first line therapy for malaria in response to increasing chloroquine resistance. in anticipation of emerging resistance to sp as a result of this change in drug pressure, we set out to define the baseline prevalence of sp-associated mutations in the dhfr and dhps genes in plasmodium falciparum using geographically diverse and longitudinally collected samples. a total of 153 blood samples were analysed from pat ... | 2005 | 16262743 |