| distribution of the two forms of plasmodium falciparum erythrocyte binding antigen-175 (eba-175) gene in lao pdr. | the erythrocyte binding antigen 175 (eba-175) is a 175 kda antigen of plasmodium falciparum and plays a major role in erythrocyte recognition by the parasite. the antigen is also supposed to be partly responsible for the invasion of erythrocytes by merozoites. eba-175 has been sequenced from the fcr-3 and camp strains of p. falciparum. the sequences were identical in most parts of the gene. differences were apparent in a 423 bp segment in the fcr-3 strain, the f-fragment, that is not found in th ... | 2003 | 12901736 |
| plasmodium falciparum: correlation of in vivo resistance to chloroquine and antifolates with genetic polymorphisms in isolates from the south of lao pdr. | levels of drug resistance of plasmodium falciparum strains against antimalarials have increased in laos. in several studies, chloroquine (cq) resistance has been associated with point mutations in the pfcrt and pfmdr genes, and sulphadoxine/pyrimethamine (s/p) resistance with point mutations in the genes of dihydrofolate reductase (dhfr) and dihydropteroate synthetase (dhps). we combined a study of these molecular markers with an in vivo antimalarial drug sensitivity study in attapeu province in ... | 2003 | 12950663 |
| serological investigation of the prevalence of anti-dengue igm and igg antibodies in attapeu province, south laos. | the prevalence of dengue antibodies was determined in the attapeu region of south laos with 225 blood samples collected from mostly febrile patients during the rainy season august - october 2001. an igm capture elisa was positive for one (0.4%) sample, while 177 (79%) samples were positive in an indirect igg elisa. of the positive igg samples, 20 (11.3%) were also positive on blood slides for plasmodium falciparum. dengue fever seems to be widespread in this area, but clinical dengue diagnosis r ... | 2004 | 14759246 |
| endemic malaria in four villages in attapeu province, lao pdr. | a study was conducted in four villages in attapeu province, lao pdr in 2002 to determine malaria endemicity. the study villages were mixay, beng phoukham, phou vong and pier geo. mass blood surveys were conducted in may, august, and october. finger prick blood was collected for thick and thin blood film as well as for dipstick. the slide positivity rate was highest in phou hom in october (41.7%). plasmodium falciparum was the dominant species comprising more than 80% of the cases. as a whole, th ... | 2004 | 15689064 |
| malaria transmission by anopheles dirus in attapeu province, lao pdr. | a study was carried out in four malaria-endemic villages in attapeu province, in the southern region of lao pdr. all-night human landing collections were carried out in may, august, and october 2002, to determine malaria vectors. at the same time, mass blood surveys were also carried out in the same villages. anopheles dirus was the predominant species in three of the study villages. sporozoites were found only in an. drius from phou hom. however, in beng phoukham, an. dirus was positive for ooc ... | 2004 | 15691129 |
| epidemiology of malaria in attapeu province, lao pdr in relation to entomological parameters. | surveys were conducted in malaria-endemic villages in the southern province of attapeu, lao pdr during various seasons over a 3-year period. all-night mosquito landing collections, blood surveys and a case-control study were conducted. plasmodium falciparum was the predominant species, and slide positivity rates were higher during the transition/dry season compared with the wet season. anopheles dirus a was found to be the primary vector, and sporozoite rates were highest during the transition/d ... | 2005 | 16112154 |