| [stability and chemosensitivity of plasmodium falciparum to chloroquine in 1990 and 1991 in ankazobe, a village in high plateau madagascar]. | the in vivo and in vitro response of plasmodium falciparum to chloroquine was conducted in ankazobe, a village located in the high plateau area. these studies confirmed the low level of chloroquine-resistance. the in vivo data indicate the absence of increase resistance during the 2 years study. chloroquine is still the drug of choice for the treatment of malaria attack in this area. | 1992 | 1422272 |
| [preliminary study on malaria transmission at the end of the rainy season in mahitsy near tananarive]. | this survey carried out from march to june 1989, demonstrated the important part of an. funestus in malaria transmission, in mahisty, a village near the malagasy capital city. end of march, the number of an. funestus bites reached 6 per man per night, and only 0.75 for an. gambiae s.l. in march a mean of 23 an. funestus per room were found as indoor resting mosquitoes. one indoor resting an. funestus, caught in june, was positive against p. vivax by elisa. observed of 52 indoor-resting an. funes ... | 1990 | 2078087 |
| [sensitivity of plasmodium falciparum to different antimalarials. a study in 1988 in a village in the hauts-plateaux of madagascar]. | since a few years, malaria has reappeared in the central highland plateaux of madagascar. from 1983 to 1987, plasmodium falciparum resistance to chloroquine remained stable, with a low frequency of r2 therapeutic failures. in 1988, a study was conducted in the village of manarintsoa, 15 km from tananarive. ninety-one who in vivo standard tests were performed. in vitro efficacy of amodiaquine and quinine was also studied. in vitro, the efficacy of chloroquine, quinine, and mefloquine was measured ... | 1989 | 2699273 |
| plasmodium falciparum malaria transmission indices in a highland village of the ikopa river valley near antananarivo, madagascar. | data are reported from a malaria survey carried out in june 1991 in the small village of ankadimbazinba, near miantso, about 45 km north-west of antananarivo (madagascar). the objective was to evaluate the level of transmission of p. falciparum by entomological, parasitological and serological indices. all indices were found consistent with the description of a focus of hyperendemic transmission dependent on the presence of an. funestus at high density, corresponding to more than 50 females per ... | 1991 | 1844515 |
| humoral and cell-mediated immune responses to the plasmodium falciparum antigens pf155/resa and cs protein: seasonal variations in a population recently reexposed to endemic malaria. | resurgence of falciparum malaria occurred in the central highlands of madagascar in the 1980s and the disease is currently hyperendemic. we determined the humoral and cellular responses to synthetic peptides reproducing the repeat sequences of 2 major plasmodium falciparum antigens: the pf155/resa and the circumsporozoite (cs) protein. blood samples from 83 subjects living in a rural community near antananarivo were obtained at the beginning and the end of the transmission season. at enrollment, ... | 1990 | 2221217 |
| [study of malaria serology using indirect immunofluorescence in children of the tananarive area. 1987]. | | 1988 | 3071975 |
| the malaria epidemic in antananarivo observed from pediatric service "a" of the befelatanana general hospital. | a recent malaria epidemic striking antananarivo, the capital city of madagascar, is shown from hospital records of pediatric service "a" of the befelatanana general hospital. from 1980 to 1988 malaria cases in this hospital service increased from 0.9% to 14.4% of all admissions (on average 1785 per year). the unexpected expansion is observed in 1984, 1985 and 1986 and since that time malaria has apparently maintained a stable endemic level. malaria mortality as a proportion of general mortality ... | 1989 | 2487897 |
| [epidemiological data on children hospitalized with malaria from 1983 to 1992]. | authors record the manifestations on the child of the severe malaria epidemic that raged in antananarivo. using the hospitalisation registers of the debré room, pediatric service "a", at the hospital of befelatanana as source documents, they underline some points: concerning morbidity, the epidemic started in 1984, reached its highest point in 1988 (26.7%, of in patients) and began to fade away in 1992. boys and girls were equally affected, with a majority among children of 5 years old and more ... | 1993 | 8192539 |
| geographic diversity of plasmodium falciparum antibodies in madagascar. | plasma samples from 50 subjects living in three distinct regions in madagascar (ankazobe, manakara, and foulpointe) were studied by sodium dodecyl sulphate polyacrylamide gel electrophoresis of immunoprecipitated proteins from a plasmodium falciparum strain (fcm22/madagascar) which had been biosynthetically labelled with 35s-methionine and maintained in long-term in-vitro culture. four major proteins with molecular weights of 96, 100, 110, and 118 kd were precipitated by plasma from ankazobe, wh ... | 1985 | 2857815 |
| [the malaria epidemic in antananarivo from 1983 to 1994 as seen through the pediatric service a in the befelatanana general hospital]. | we report the symptoms of children affected by an epidemy of a serious form of malaria which raged in tananarive from 1983 to 1994. these data are based on the hospital registers for the "debré" room of the pediatric service "a" in the befelatanana hospital, and underline a few points as follows. in terms of morbidity, the epidemy started in 1984, reached a peak in 1988 (26.7% of the admitted), and started to spread in 1992. boys and girls were equally affected, with the majority of children bei ... | 1995 | 8784544 |
| [4-aminoquinoline-sensitivity of plasmodium falciparum in madagascar. iii. studies in three regions of the interior]. | among 273 malarial patients recruited through passive detection, 177 in vivo tests were performed in andekaleka and ankazobe and 23 in vitro tests in ifanadiana, and ankazobe (inland of madagascar). in vivo, chloroquine failed within 7 days at 10 mg/kg in 28/86 patients, at 25 mg/kg in 7/34 and amodiaquine failed in 5/55 with 10 mg/kg and in 0/14 with 25 mg/kg. in vitro, the semi-microtest revealed resistance to chloroquine of 1/23 isolates (ic50 = 750 nm/1) but high sensitivity to amodiaquine, ... | 1984 | 6398674 |
| [in vitro sensitivity of plasmodium falciparum to chloroquine in the highland region of madagascar in 1987]. | with the le bras's isotopic semi-microtest method, the authors have studied 139 strains of plasmodium falciparum isolated in a village near tananarive in the highlands of madagascar. conditional malariometric rates show the increase of the recrudescence of malaria in the area which was recently considered as "surveillance area". 5.8% of the 139 studied strains show an in vitro resistance higher than 120 nmoles/l, but whose the level is ever lower than in africa. 4.3% exhibit a level between 90 a ... | 1988 | 3052898 |
| igg1 and igg2 antibody responses to plasmodium falciparum exoantigens correlate inversely and positively, respectively, to the number of malaria attacks. | in manarintsoa, near antananarivo, madagascar, two groups of patients were defined in terms of malaria clinical immune status: group ma+ consisted of 36 patients who suffered from between one to four malaria attacks (ma) during the 20-week study, and group ma- who comprised of 48 persons who did not have any malaria attacks during this time. in group ma+, igm and igg antibody levels to plasmodium falciparum exoantigens (e-ag) were inversely related to the number of malaria attacks. the level of ... | 1996 | 8809551 |
| circulating stable antigens at higher levels down-regulate antibody responses to plasmodium falciparum. | a study involving 169 schoolchildren (5-14 years old) living in manarintsoa near antananarivo (madagascar, east africa) was performed during the seasonal malaria transmission period. for the whole population examined, the prevalence of plasmodium falciparum and the rates of spleen enlargement and of circulating stable antigen (s-ag) were found to be 60.9%, 71.7%, and 46.8%, respectively. the prevalence of igg antibody to resa (ring-infected erythrocyte surface antigen) was 42.7% and that of igg ... | 1993 | 8475036 |
| [the impact of curtains impregnated with deltamethrin on the vectors and morbidity of malaria: results in ankazobe, on the plateaus of madagascar]. | to evaluate the efficacy of deltamethrin impregnated curtains on malaria morbidity in a low transmission area, we studied volunteer families in the village of ankazobe in the madagascar highlands from february 1993 to june 1994. after randomization, we provided 46 houses having 244 inhabitants with impregnated curtains (i) and 45 others having 257 inhabitants with nonimpregnated curtains (ni) as controls. we first estimated the number of mosquito bites in the protected versus nonprotected househ ... | 1997 | 9172875 |
| control of epidemic malaria on the highlands of madagascar. | the malagashy national malaria control programme ('programme national de lutte contre le paludisme', pnlp) has been developing, since 1996, an epidemiological early warning system for malaria epidemics in the central highlands with the support of the italian development cooperation. the system is based on the monitoring of malaria morbidity (clinical diagnosis) in 536 peripheral health centres (csb) of the highlands. the intervention area corresponds to 27 districts of the antananarivo and fiana ... | 1999 | 10697886 |
| [drug resistance of plasmodium falciparum along the borders of the highlands in madagascar: outlook for a national control program]. | resistance of plasmodium falciparum to chloroquine was first suspected in madagascar in 1975 and later confirmed in vivo and in vitro. during the period from 1985 and 1990, the network of public health monitoring stations reported that 1% of the population living on the central highlands of madagascar died of malaria. thereafter the national malaria control program achieved good success by spraying homes with insecticide and reorganizing distribution of chloroquine in all villages. however data ... | 1998 | 10088103 |
| low autochtonous urban malaria in antananarivo (madagascar). | the study of urban malaria is an area undergoing rapid expansion, after many years of neglect. the problem of over-diagnosis of malaria, especially in low transmission settings including urban areas, is also receiving deserved attention. the primary objective of the present study was to assess the frequency of malaria among febrile outpatients seen in private and public primary care facilities of antananarivo. the second aim was to determine, among the diagnosed malaria cases, the contribution o ... | 2006 | 16573843 |
| plasmodium falciparum: a comparative analysis of the genetic diversity in malaria-mesoendemic areas of brazil and madagascar. | for a better definition of the polymorphic features of plasmodium falciparum parasite populations, the polymerase chain reaction (pcr) typing technique was used to investigate the genetic diversity and complexity of parasites harbored by acute p. falciparum carriers from three yet unexplored malaria-mesoendemic areas with different transmission levels: two localities in northwestern brazil (ariquemes and porto velho) and a village in madagascar (ankazobe). a total of 89 dna samples were analyzed ... | 2000 | 10952272 |
| in-vitro sensitivity of plasmodium falciparum to chloroquine, halofantrine, mefloquine and quinine in madagascar. | to determine how sensitive plasmodium falciparum is to the major antimalarial drugs in madagascar. | 2002 | 12638806 |
| [diagnosis of malaria in antananarivo city: examination of the results obtained at the institut pasteur de madagascar from 2001 to 2004]. | malaria diagnosis is part of the daily activities of the clinical biology center (cbc) of the institut pasteur de madagascar in antananarivo. over a period of four years (2001-2004), regardless the methods being used, out of 6537 blood samples examined, 159 (2.43%) tests were positive. all four species of plasmodium infecting human. were detected with a high prevalence of p. falciparum (87.2%). 49/159 patients were foreigners, but their files did not allow us to distinguish imported from locally ... | 2006 | 16983826 |
| seroprevalence of malaria in inhabitants of the urban zone of antananarivo, madagascar. | antananarivo, the capital of madagascar, is located at an altitude of over 1,200 m. the environment at this altitude is not particularly favourable to malaria transmission, but malaria nonetheless remains a major public health problem. the aim of this study was to evaluate exposure to malaria in the urban population of antananarivo, by measuring the specific seroprevalence of plasmodium falciparum. | 2006 | 17096830 |
| [malaria in the urban highland area of antananarivo, madagascar: bioecology of anopheles arabiensis]. | an entomological study was performed to document the transmission of plasmodium, agents of human malaria in antananarivo, capital of madagascar. human landing mosquitoes were collected at night during two years, between may 2003 and september 2005, in the two sites of ambohimiandra-manakambahiny and ambolokandrina. the genuses of collected mosquitoes were, in order of abundance, culex, mansonia and anopheles. the only potential vector was anopheles arabiensis. its maximal abundance was observed ... | 2008 | 18956819 |
| [malaria cases diagnosed at the parasitology department of the joseph-ravoahangy-andrianavalona university hospital centre, antananarivo, madagascar, 2005-2008]. | | 2010 | 20525547 |