Publications

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Serologic Markers in Relation to Parasite Exposure History Help to Estimate Transmission Dynamics of Plasmodium vivax.Plasmodium vivax infection has been gaining attention because of its re-emergence in several parts of the world. Southeastern Turkey is one of the places in which persistent focal malaria caused exclusively by P. vivax parasites occurs. Although control and elimination studies have been underway for many years, no detailed study has been conducted to understand the mechanisms underlying the ineffective control of malaria in this region. Here, for the first time, using serologic markers we try to ...201122140521
monitoring of failure of chloroquine treatment for plasmodium vivax using polymerase chain reaction in sanliurfa province, turkey.malaria is a complex disease that varies widely in epidemiology and clinical manifestation in the southeastern part of turkey. in many regions of the world, chloroquine (cq) has been the standard treatment for plasmodium vivax. however, the resistance of the plasmodium species to antimalarial drugs has become an increasing problem and a concern worldwide. our target was to determine the plasmodium species in the southeast region of turkey and the therapeutic efficacy of cq used in the treatment ...201020140453
analysis of naturally acquired antibody responses to the 19-kd c-terminal region of merozoite surface protein-1 of plasmodium vivax from individuals in sanliurfa, turkey.plasmodium vivax is the second most prevalent global plasmodium species causing malaria after p. falciparum. these two plasmodium spp. co-exist in most endemic areas, apart from west and central africa, which has only p. falciparum. however, southeastern turkey is one of the exceptional regions with the sole presence of p. vivax infection, where a thorough epidemiologic survey has not been performed. here, we report for the first time the identification of naturally acquired antibodies against t ...200818458304
parasite density and serum cytokine levels in plasmodium vivax malaria in turkey.we aimed to investigate the relationship between quantitative plasmodium vivax parasitaemia and serum cytokine levels in a highly endemic region of turkey, where such a relation has not been investigated before. active screening was done in a total of 1316 people residing in 33 villages of sanliurfa province, turkey. the study population consisted of 79 consecutive patients with p. vivax malaria, and a control group included 89 healthy subjects. thick blood smears were examined for malaria paras ...200616629705
the decreasing efficacy of chloroquine in the treatment of plasmodium vivax malaria, in sanliurfa, south-eastern turkey.in most regions of the world, chloroquine has been the standard treatment for plasmodium vivax malaria for more than 50 years. recently, however, chloroquine-resistant p. vivax has been reported from oceania, several parts of asia, and south america. in june-august 2004, therapeutic failure following chloroquine treatment of acute p. vivax malaria was investigated among 91 patients from two sites (karacadag and sekerli) in the turkish province of sanliurfa. each patient received a directly obser ...200616492358
comparison with the pan malaria igg assays for malaria diagnosis and direct microscopy among suspected malaria patients in sanliurfa.in this study, we evaluated the usage of the pan malaria igg celisa test in the diagnosis of malarial infections in siverek-sanliurfa, turkey, where malarial infection is endemic and there are minimal health services available. the pan malaria igg celisa (cellabs) test, which uses recombinant antigens and detects exposure to all four forms of malaria (p. falciparum, p. vivax, p. ovale and p. malariae) was used as individuals. using the consensus microscopy results as the standard, sensitivity of ...200616483425
[characteristics of malaria cases diagnosed in edirne province between 1994-2002].in this study, the epidemiological characteristics of malaria cases in edirne province were investigated. between the years of 1994-2002, a total of 317,087 blood samples were collected from soldiers in the province with selective active surveillance and from the resident population with active or passive surveillance methods, by the medical staff of malaria control department and health centers, to search the presence of plasmodium. in 281 of them plasmodium spp. were detected, and the characte ...200415293910
efficacy of chloroquine in the treatment of plasmodium vivax malaria in turkey.in most regions of the world, chloroquine (cq) has been the standard treatment for plasmodium vivax malaria for more than 40 years. recently, however, cq-resistant p. vivax has been reported from oceania, several parts of asia, and south america. the therapeutic efficacy of cq in the treatment of acute, p. vivax malaria has now been assessed in two areas of the turkish province of sanliurfa: the towns of karacadag and sekerli. on admission and on days 2, 3, 7, 14, 21, and 28, all 112 patients in ...200415257793
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