| [in vivo response to chloroquine during the treatment of plasmodium falciparum malaria in a suburban region of kinshasa, zaire]. | | 1985 | 3907530 |
| high-throughput pooling and real-time pcr-based strategy for malaria detection. | molecular assays can provide critical information for malaria diagnosis, speciation, and drug resistance, but their cost and resource requirements limit their application to clinical malaria studies. this study describes the application of a resource-conserving testing algorithm employing sample pooling for real-time pcr assays for malaria in a cohort of 182 pregnant women in kinshasa. a total of 1,268 peripheral blood samples were collected during the study. using a real-time pcr assay that det ... | 2010 | 19940051 |
| pharmacokinetics and pharmacodynamics of artesunate and dihydroartemisinin following oral treatment in pregnant women with asymptomatic plasmodium falciparum infections in kinshasa drc. | in many malaria-endemic countries, increasing resistance may soon compromise the efficacy of sulphadoxine-pyrimethamine (sp) for intermittent preventative treatment (ipt) of malaria in pregnancy. artemisinin-based ipt regimens represent a promising potential alternative to sp. pharmacokinetic and safety data supporting the use of artemisinin derivatives in pregnancy are urgently needed. | 2011 | 21352601 |
| [malaria prevalence at delivery in four maternity hospitals of kinshasa city, democratic republic of congo]. | in areas with stable transmission, malaria is an alarming threat both for mothers (anemia) and fetus (abortion, premature birth, a birth ponderal deficit, death in utero). our study aims at estimating the malaria prevalence among parturients and their newborn babies in kinshasa, democratic republic of congo, in order to conduct the national programme of control. between september and november 2004, 196 pregnant women aged of 14 to 45 years old (average: 25.8 years) were recruited consecutively f ... | 2006 | 16983827 |
| malaria in primary school children and infants in kinshasa, democratic republic of the congo: surveys from the 1980s and 2000. | kinshasa, the capital of the democratic republic of the congo, has been a perennial malarious area and has grown almost 14 times from 380,000 people in 1960 to 5,293,000 in 2003. the most complete information on malaria prevalence in kinshasa was first acquired in 1981-1983. blood smears were obtained from 25,135 children (ages 5-15 years) from 245 schools in 16 of 24 zones. the mean plasmodium falciparum parasite rate was 17%; the parasite rate was similar for both sexes and was higher (p < 0.0 ... | 2004 | 15331825 |
| antimalarial activity of 20 crude extracts from nine african medicinal plants used in kinshasa, congo. | twenty extracts including ten etoh and ten ch2cl2 from different parts of nine african medicinal plants used in congolese traditional medicine for the treatment of malaria, were submitted to a pharmacological test in order to evaluate their effect on p. falciparum growth in vitro. of these plant species, 14 (70%) extracts including etoh and ch2cl2 from cassia occidentalis leaves, cryptolepis sanguinolenta root bark, euphorbia hirta whole plant, garcinia kola stem bark and seeds, morinda lucida l ... | 1999 | 10624878 |
| plasmodium falciparum-associated anemia in children at a large urban hospital in zaire. | chloroquine-resistant plasmodium falciparum malaria and human virus (hiv) infection through blood transfusions used to treat malaria-associated anemia are causes of increasing morbidity and mortality among children in africa. to evaluate the role of malaria and other risk factors for pediatric anemia, we conducted a study of children brought to the emergency ward of a large urban hospital in kinshasa, zaire. a total of 748 children ages six through 59 months were enrolled; 318 (43%) children wer ... | 1993 | 8470774 |
| [relationship between plasmodium parasitemia and febrile episodes in various population groups in kinshasa, zaire]. | the objective of this study was to determine the relative importance of determinants of fever-episodes in an environment with perennial malaria transmission. in 6 neighbourhoods of kinshasa with different degrees of urbanization, 120 clusters of children younger than 10 years were selected over a one year period and followed up for 2 weeks each. in the 4,816 children retained for analysis 906 fever episodes were registered, which corresponds to an average incidence rate of 4.9 episodes per child ... | 1994 | 7726662 |
| [survey of the epidemiological status of malaria in kinshasa (republic of zaire) in 1980]. | | 1982 | 6756325 |
| in vivo and in vitro susceptibility to chloroquine of plasmodium falciparum in kinshasa and mbuji-mayi, zaire. | from april to june 1983, combined in vivo and in vitro studies were conducted to assess the response to chloroquine of plasmodium falciparum in kinshasa and mbuji-mayi, zaire. a total of 109 patients were treated with chloroquine, either as a single dose of 10 mg/kg or as a full dose of 25 mg/kg. all patients rapidly cleared their asexual parasitaemia, no recurrence being noted during the subsequent 3 weeks of follow-up. in the fourth week, recurrences were noted in 3 out of 66 patients treated ... | 1985 | 3893776 |
| absence of association between plasmodium falciparum malaria and human immunodeficiency virus infection in children in kinshasa, zaire. | the possible associations between plasmodium falciparum malaria and hiv (human immunodeficiency virus) seropositivity were investigated in 1986 at the mama yemo hospital in kinshasa, zaire. no significant difference was found in the hiv seropositivity rate of 164 children presenting with p. falciparum malaria (1.2%) and 169 healthy controls (0.6%). secondly, no association was found between p. falciparum slide positivity (51.6%) and hiv seropositivity (3.8%) among 1046 children presenting to the ... | 1987 | 3322600 |
| plasmodium falciparum in kinshasa, zaire: in vitro drug susceptibility studies. | in june 1986, plasmodium falciparum parasites were collected from 33 children presenting at the mama yemo hospital in kinshasa (zaire) and were successfully tested in vitro by a 48-hr reinvasion test for their susceptibility to various antimalarial drugs. in vitro resistance to chloroquine was found in 82% of the isolates, a marked increase over findings obtained by the same technique 3 years ago in kinshasa. in vitro chloroquine resistance was not associated with a history of previous drug inta ... | 1987 | 3310676 |
| [malaria and pregnancy. epidemiological situation in kinshasa (zaïre)]. | by regular blood smears to 730 women (430 pregnant women and 250 non pregnant) authors state precisely epidemiologic situation of malaria to women at kinshasa. the prevalence of malaria of pregnant women is 22 per cent against 6.1 per cent for non pregnant adult women. malarial infestation in gravido-puerperal period is : mother : 23.7 per cent ; umbilical cord : 3.1 per cent ; newborn : 5.4 per cent ; placenta : 10.1 per cent. plasmodium falciparum is the principal agent of malaria at kinshasa. ... | 1988 | 3283914 |
| the association between malaria, blood transfusions, and hiv seropositivity in a pediatric population in kinshasa, zaire. | since plasmodium falciparum malaria is a frequent cause of anemia among african children, and blood transfusions, unscreened for human immunodeficiency virus (hiv) antibody, are used frequently in the treatment of children with severe malaria, the relationships between malaria, transfusions, and hiv seropositivity were investigated in a pediatric population in kinshasa, zaire. in a cross-sectional survey of 167 hospitalized children, 112 (67%) had malaria, 78 (47%) had received transfusions duri ... | 1988 | 3275815 |
| response of children with plasmodium falciparum to chloroquine and development of a national malaria treatment policy in zaire. | in vivo sensitivity of plasmodium falciparum to chloroquine was evaluated in 4 of 9 regions of zaire in 1985 to develop a national strategy for treatment of malaria. children less than 5 years of age were treated with either a single dose of chloroquine base, 10 mg/kg, or a dose of 25 mg/kg given over 3 d. a modified 7-day world health organization in vivo test was used with follow-up 2, 3 and 7 d after the start of treatment. 339 children were studied. in bwamanda 92% of children were aparasita ... | 1988 | 3068841 |
| hospital-based surveillance of malaria-related paediatric morbidity and mortality in kinshasa, zaire. | although plasmodium falciparum malaria is a leading cause of paediatric morbidity and mortality in africa, few quantitative estimates are available about the impact of malaria on childhood health. to quantify the impact of the disease in an urban african setting, we reviewed the paediatric ward and mortuary records at mama yemo hospital in kinshasa, zaire. from june 1985 to may 1986, 6208 children were admitted to the hospital, 2374 (38.2%) of whom had malaria; 500 of those with malaria died (ca ... | 1989 | 2743538 |
| intravenous quinine therapy of hospitalized children with plasmodium falciparum malaria in kinshasa, zaire. | to examine the clinical and parasitologic efficacy of quinine, we studied 34 children (7 months-13 years old) with severe or moderately severe plasmodium falciparum infections. quinine 10 mg/kg every 8 hr for 3 days was administered, initially by intravenous infusion of quinine formate followed by oral quinine dihydrochloride when tolerated. thirty-three of the 34 patients were clinically well and had negative malaria smears 7 days after the initiation of therapy; 1 child, who presented in coma, ... | 1989 | 2653061 |
| incidence of malaria and efficacy of oral quinine in patients recently infected with human immunodeficiency virus in kinshasa, zaire. | there is concern that the impaired cell mediated immunity caused by the human immunodeficiency virus may increase the risk of severity of plasmodium falciparum infection and could lead eventually to a decreased response to standard antimalarial treatment. in 1986, at mama yemo hospital, kinshasa, zaire, the incidence of malaria was determined in a cohort of 59 patients who had recently acquired hiv-i infection through blood transfusion and in a cohort of 83 hiv-i seronegative controls who were r ... | 1990 | 2230175 |
| [epidemiology of congenital malaria in the urban milieu of kinshasa (zaire)]. | thick blood films for detection of hematozoa were routinely performed in 953 neonates and their mothers within 12 hours of delivery. hematozoa were found in 4% of neonates and 13% of mothers. positive tests were found in 19 neonates born to mothers with negative tests. mean birth weight was 3,166 g in infected neonates and 3,171 g in uninfected neonates, suggesting that congenital malaria has no effect on birth weight. | 1990 | 2190523 |
| plasmodium falciparum malaria and perinatally acquired human immunodeficiency virus type 1 infection in kinshasa, zaire. a prospective, longitudinal cohort study of 587 children. | it is uncertain whether plasmodium falciparum malaria is more frequent or more severe in children with perinatally acquired human immunodeficiency virus type 1 (hiv-1) infection and whether p. falciparum infection accelerates the progression of hiv-related disease. | 1991 | 2052043 |
| prospects for malaria control in urban and rural kinshasa. | malaria is a major cause of paediatric illness and death in kinshasa, and all 3 million inhabitants are at risk. in view of the increasing chloroquine-resistance of plasmodium falciparum, the early treatment of fever cases as the sole malaria control measure is no longer acceptable. the prospects for vector control are determined by the effectiveness, the acceptability and the practicability of the various methods in the local conditions of kinshasa. pronounced differences in the level of endemi ... | 1991 | 1793262 |
| infant and child mortality and malaria in the congo. the trend in the suburbs of brazzaville between 1981 and 1988. | this survey was carried out on a cohort of children born between 1st january 1981 and 30th june 1987 in the maternity department of the hospital in linzolo, a village situated 25 km south-west of brazzaville, the capital of the congo. the mothers of the children resided in the suburbs of brazzaville at the time of delivery. in this region, the rate of transmission of plasmodium falciparum malaria is high without marked seasonable variations. the mothers and children were traced in the second qua ... | 1992 | 1470838 |
| resistance-mediating polymorphisms in plasmodium falciparum infections in kinshasa, democratic republic of the congo. | genetic polymorphisms in plasmodium falciparum are associated with resistance to a number of drugs, but data on their prevalence are limited from many areas. we explored the prevalence of key polymorphisms in patients presenting with malaria in kinshasa. prevalences of pfcrt k76t; pfmdr1 n86y; pfdhfr n51i, c59r, and s108n; and pfdhps a437g were well above 50% and of pfmdr1 y184f, n1042d, and d1246y; pfdhfr i164l; and pfdhps k540e were low. these results suggest an intermediate level of resistanc ... | 2009 | 19346374 |
| short report: analysis of anti-malaria immune response during human immunodeficiency virus infection in adults in kinshasa, democratic republic of the congo. | co-infection of human immunodeficiency virus and malaria is not uncommon in people living in sub-saharan africa. since hiv infection results in immune deficiency, it may alter the ability of hiv patients to mount proper immune responses against malaria parasites. we measured specific malaria antibodies in 47 specimens from 25 couples from kinshasa, democratic republic of the congo (drc), according to their hiv status, and investigated probable interaction between malaria and hiv infection. plasm ... | 2003 | 12685648 |
| relationship of antibodies to soluble plasmodium falciparum antigen (pf70) and protection against malaria in a human population living under intense transmission in kinshasa, zaire. | the rapid acquisition of resistance by plasmodium falciparum to antimalarial drugs has focused worldwide efforts on vaccine development. the definition of critical antigens involved in the induction of protective immunity against disease is essential. our previous studies have characterized a synthetic peptide complex (spf70), derived from a 70 kda p. falciparum exoantigen, in terms of its immunogenicity and antigenic reactivity. in the present study total anti-p. falciparum asexual blood-stage ... | 1995 | 8525288 |
| malaria in urban and rural kinshasa: the entomological input. | mosquitoes were collected on human bait over a 16-month period (september 1988 to december 1989) in an urban and a rural area of kinshasa, zaïre. p. falciparum malaria sporozoite rates were determined by elisa. in the urban area culex quinquefasciatus accounts for 96% of the 121 bites/person/night (b/p/n). the only anopheline is anopheles gambiae, sensu stricto, with an average of 5.1 b/p/n and a sporozoite rate of 1.86%. the entomological inoculation rate (eir) averages 0.08 infective b/p/n. ma ... | 1993 | 8481529 |