| anti-plasmodial activity and toxicity of extracts of plants used in traditional malaria therapy in meru and kilifi districts of kenya. | the methanol and aqueous extracts of 10 plant species (acacia nilotica, azadirachta indica, carissa edulis, fagaropsis angolensis, harrissonia abyssinica, myrica salicifolia, neoboutonia macrocalyx, strychnos heningsii, withania somnifera and zanthoxylum usambarensis) used to treat malaria in meru and kilifi districts, kenya, were tested for brine shrimp lethality and in vitro anti-plasmodial activity against chloroquine-sensitive and chloroquine-resistant strains of plasmodium falciparum (nf54 ... | 2006 | 16530996 |
| tigliane diterpenoids from the stem bark of neoboutonia macrocalyx. | neoboutonia macrocalyx is a plant used by traditional healers among the meru community in kenya. chromatographic fractionation of the petroleum ether and dichloromethane extracts of this plant yielded one known (1) and three new tigliane-type diterpenoids (2-4). the chemical structures of the isolated compounds were established through spectroscopic data interpretation. | 2007 | 17381153 |
| antimalarial activity of some plants traditionally used in meru district of kenya. | ten plant extracts commonly used by the meru community of kenya were evaluated for the in vitro antiplasmodial, in vivo antimalarial, cytotoxicity and animal toxicity activities. the water and methanol extracts of ludwigia erecta and the methanol extracts of fuerstia africana and schkuhria pinnata exhibited high antiplasmodial activity (ic(50) < 5 microg/ml) against chloroquine sensitive (d6) and resistant (w2) plasmodium falciparum clones. the cytotoxicity of these highly active extracts on ver ... | 2007 | 17486688 |
| the in vitro anti-plasmodial and in vivo anti-malarial efficacy of combinations of some medicinal plants used traditionally for treatment of malaria by the meru community in kenya. | the use of herbal drugs as combinations has existed for centuries in several cultural systems. however, the safety and efficacy of such combinations have not been validated. in this study, the toxicity, anti-plasmodial and antimalarial efficacy of several herbal drug combinations were investigated. lannea schweinfurthii, turraea robusta and sclerocarya birrea, used by traditional health practitioners in meru community, were tested for in vitro anti-plasmodial and in vivo anti-malarial activity s ... | 2008 | 18065175 |
| epidemiology of malaria in kenya. | more than four million cases of malaria are reported annually in kenya. a 5.1% mortality rate has been reported among patients admitted with severe malaria. although plasmodium falciparum is the species most frequently associated with severe malaria and accounts for 80-90% of cases in kenya, p. malariae, p. ovale, and p. vivax also exist in the country. vector species in kenya are members of the anopheles gambiae complex and a. funestus. transmission patterns of the disease in kenya are infl ... | 1994 | 12287810 |
| comparison of blood smear microscopy to a rapid diagnostic test for in-vitro testing for p. falciparum malaria in kenyan school children. | to compare the diagnostic performance of microscopy using giemsa-stained thick and thin blood smears to a rapid malaria dipstick test (rdt) in detecting p. falciparum malaria in kenyan school children. | 2008 | 19413207 |
| schistosomiasis mansoni in kenya: relationship between infection and anaemia in schoolchildren at the community level. | haematological surveys were carried out in 3 schools in 2 areas where schistosoma mansoni is endemic in machakos district, kenya, before and after a treatment campaign using praziquantel. earlier clinical impressions of differences in the levels of anaemia between the 2 areas were not confirmed. although individual haemoglobin levels and haematocrits often fell below international norms, significant anaemia with abnormal red blood cell morphology was rare (< 5%), but varied between schools. alti ... | 1996 | 8730312 |
| anti-plasmodial activity of the extracts of some kenyan medicinal plants. | the spread of drug resistant plasmodium falciparum strains necessitates search for alternative newer drugs for use against malaria. medicinal plants used traditionally in preparation of herbal medicines for malaria are potential source of new anti-malarial drugs. | 2009 | 19041710 |
| age-adjusted plasmodium falciparum antibody levels in school-aged children are a stable marker of microgeographical variations in exposure to plasmodium infection. | amongst school-aged children living in malaria endemic areas, chronic morbidity and exacerbation of morbidity associated with other infections are often not coincident with the presence or levels of plasmodium parasitaemia, but may result from long-term exposure to the parasite. studies of hepatosplenomegaly associated with schistosoma mansoni infection and exposure to plasmodium infection indicate that differences that occur over 1-2 km in levels of plasmodium transmission are related to the de ... | 2007 | 17603885 |