Publications

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invasive bacterial and fungal infections among hospitalized hiv-infected and hiv-uninfected children and infants in northern tanzania.objective  to describe the contribution of paediatric hiv and of hiv co-infections to admissions to a hospital in moshi, tanzania, using contemporary laboratory methods. methods  during 1 year, we enrolled consecutively admitted patients aged ≥2 months and <13 years with current or recent fever. all patients underwent standardized clinical history taking, a physical examination and hiv antibody testing; standard aerobic blood cultures and malaria film were also done, and hospital outcome was rec ...201121470347
invasive bacterial and fungal infections among hospitalized hiv-infected and hiv-uninfected adults and adolescents in northern tanzania.few studies describe patterns of human immunodeficiency virus (hiv) co-infections in african hospitals in the antiretroviral therapy (art) era.201121217181
the dynamics of naturally acquired immune responses to plasmodium falciparum sexual stage antigens pfs230 & pfs48/45 in a low endemic area in tanzania.naturally acquired immune responses against sexual stages of p. falciparum can reduce the transmission of malaria from humans to mosquitoes. these antigens are candidate transmission-blocking vaccines but little is known about the acquisition of sexual stage immunity after exposure to gametocytes, or their longevity and functionality. we conducted a longitudinal study on functional sexual stage immune responses.201021124765
behavioural and insecticidal effects of organophosphate-, carbamate- and pyrethroid-treated mosquito nets against african malaria vectors.three insecticides - the pyrethroid deltamethrin, the carbamate carbosulfan and the organophosphate chlorpyrifos-methyl - were tested on mosquito nets in experimental huts to determine their potential for introduction as malaria control measures. their behavioural effects and efficacy were examined in anopheles gambiae giles s.s. (diptera: culicidae) and anopheles funestus giles s.s. in muheza, tanzania, and in anopheles arabiensis patton and culex quinquefasciatus say in moshi, tanzania. a stan ...200919941597
rapid assessment of malaria transmission using age-specific sero-conversion rates.malaria transmission intensity is a crucial determinant of malarial disease burden and its measurement can help to define health priorities. rapid, local estimates of transmission are required to focus resources better but current entomological and parasitological methods for estimating transmission intensity are limited in this respect. an alternative is determination of antimalarial antibody age-specific sero-prevalence to estimate sero-conversion rates (scr), which have been shown to correlat ...200919562032
submicroscopic plasmodium falciparum gametocyte carriage is common in an area of low and seasonal transmission in tanzania.recently developed molecular gametocyte detection techniques have shown that submicroscopic plasmodium falciparum gametocytes are common in symptomatic patients and can infect mosquitoes. the relevance for the infectious reservoir of malaria in the general population remains unknown. in this study, we investigated submicroscopic asexual parasitaemia and gametocytaemia in inhabitants of an area of hypoendemic and seasonal malaria in tanzania.200717445146
spatial and temporal variation in malaria transmission in a low endemicity area in northern tanzania.spatial and longitudinal monitoring of transmission intensity will allow better targeting of malaria interventions. in this study, data on meteorological, demographic, entomological and parasitological data over the course of a year was collected to describe malaria epidemiology in a single village of low transmission intensity.200617081311
altitude-dependent and -independent variations in plasmodium falciparum prevalence in northeastern tanzania.effective malaria control requires information about intensity of transmission across large areas and populations. estimates based on entomological factors lack precision and are not cost-effective to obtain. we tested altitude and rainfall measurements as correlates of transmission intensity in different ecological settings.200515838785
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