| hepatitis c virus infection among alaskan drug users. | | 1997 | 9357367 |
| hepatocellular carcinoma not related to hepatitis b virus infection among alaska natives. | chronic infection with hepatitis b or c viruses is a common underlying condition in patients with hepatocellular carcinoma worldwide. we studied serum and liver tissue from a cohort of alaska natives with hepatocellular carcinoma (hcc) for evidence of hepatitis b, c and g viral infection using conventional serological tests as well as the sensitive polymerase chain reaction. evidence of hbv infection was found in 25 and possible hcv infection in two cases. among the remaining 11 patients, four h ... | 1999 | 10528471 |
| community well being and infectious diseases among alaska native communities in the chugach region. | this study sought to examine how native people of the chugach region of alaska perceive their own communities' health and well being, particularly in regard to infectious diseases. | 2001 | 11768448 |
| epidemiology and risk factors for hepatitis c in alaska natives. | large cohorts of persons infected with hepatitis c virus (hcv) that include patients with multiple risk exposures and behaviors have been rarely reported. we herein describe a population-based cohort of 759 alaska natives (an) with hcv who were recruited into a long-term follow-up study. history of injection drug use (idu) was reported by 60.1% and blood transfusion by 14.0%. the most common genotype was 1a (42.0%), followed by 1b (20.3%), 2b (14.7%), 3a (14.3%), and 2a (7.8%). by multivariable ... | 2004 | 14767985 |
| results of a hepatitis c general transfusion lookback program for patients who received blood products before july 1992. | the centers for disease control and prevention recommend hepatitis c virus (hcv) antibody (anti-hcv) screening for persons who received blood products before july 1992. a general transfusion lookback program was implemented to identify, counsel, and screen persons who received transfusions at the alaska native medical center between january 1980 and july 1992. | 2005 | 15935002 |
| high rate of spontaneous negativity for hepatitis c virus rna after establishment of chronic infection in alaska natives. | hepatitis c virus (hcv) leads to chronic infection in 70%-85% of exposed patients. spontaneous clearance of the virus after chronic infection is believed to occur rarely. | 2006 | 16511757 |
| hepatitis c infection in alaska natives with persistently normal, persistently elevated or fluctuating alanine aminotransferase levels. | an estimated one-third of patients with chronic hepatitis c virus (hcv) infection have persistently normal alanine transaminase (pnalt); however, in many previous studies alanine aminotransferase (alt) levels were followed for < or = 12 months. | 2006 | 16842319 |
| steatosis and hepatitis c in an alaska native/american indian population. | to determine the prevalence and characteristics of steatosis in alaska natives/american indians (an/ai) with chronic hepatitis c virus (hcv) infection. | 2006 | 16871831 |
| results of a general hepatitis c lookback program for persons who received blood transfusions in a neonatal intensive care unit between january 1975 and july 1992. | to notify persons who received a blood transfusion in a neonatal intensive care unit between january 1975 and july 1992 of their risk for hepatitis c infection and to encourage them to seek hepatitis c antibody testing. | 2007 | 17283296 |
| clinical significance of elevated alpha-fetoprotein in alaskan native patients with chronic hepatitis c. | the clinical significance of elevated serum alpha-fetoprotein (afp) in patients with chronic hepatitis c virus (hcv) infection is not well defined. we analysed data from a population-based cohort of patients with hcv infection to assess the prevalence of elevated serum afp, to determine its association with clinical and virologic parameters and with clinical outcomes. we defined a slightly elevated serum afp level as 8 to <15 and a high-afp level as > or =15 microg/l. among 541 hcv-rna-positive ... | 2008 | 18233991 |
| changing trends in hepatitis c-related mortality in the united states, 1995-2004. | the disease burden and mortality from hepatitis c are predicted to increase in the united states as the number of persons with long-standing chronic infection grows. we analyzed hepatitis c mortality rates derived from us census and multiple-cause-of-death data for 1995-2004. deaths were considered hepatitis c-related if: (1) hepatitis c was the underlying cause of death, (2) chronic liver disease was the underlying cause and hepatitis c was a contributing cause, or (3) human immunodeficiency vi ... | 2008 | 18318441 |
| chronic liver disease among alaska-native people, 2003-2004. | a higher proportion of deaths among american-indian/alaska-native (ai/an) people has been attributed to chronic liver disease (cld) compared with other racial/ethnic groups in the united states. the objectives of this study were to determine cld prevalence and to define its etiologies and complications among an and ai people, who received health care from an urban hospital center. | 2009 | 19174808 |
| adverse outcomes in alaska natives who recovered from or have chronic hepatitis c infection. | the factors associated with adverse outcome from hepatitis c virus (hcv) infection are incompletely understood. to determine the incidence and risk factors associated with the development of end-stage liver disease (esld) and liver-related death (lrd), we conducted a retrospective/prospective population-based study in a cohort of alaska native persons chronically infected with hcv from 1994 to 2005. | 2010 | 19909749 |
| factors associated with the progression of fibrosis on liver biopsy in alaska native and american indian persons with chronic hepatitis c. | various factors influence the development and rate of fibrosis progression in chronic hepatitis c virus (hcv) infection. | 2010 | 20652161 |
| changing trends in viral hepatitis-associated hospitalizations in the american indian/alaska native population, 1995-2007. | we described the changing epidemiology of viral hepatitis among the american indian/alaska native (ai/an) population that uses indian health service (ihs) health care. | 2011 | 22043097 |
| the association between race/ethnicity and the effectiveness of direct antiviral agents for hepatitis c virus infection. | black race and hispanic ethnicity were associated with lower rates of sustained virologic response (svr) to interferon-based treatments for chronic hepatitis c virus infection, whereas asian race was associated with higher svr rates compared to white patients. we aimed to describe the association between race/ethnicity and effectiveness of new direct-acting antiviral regimens in the veterans affairs health care system nationally. we identified 21,095 hepatitis c virus-infected patients (11,029 [ ... | 2017 | 27775854 |
| infection with hepatitis c virus genotype 3 is an independent risk factor for end-stage liver disease, hepatocellular carcinoma, and liver-related death. | few studies have examined factors associated with disease progression in hepatitis c virus (hcv) infection. we examined the association of 11 risk factors with adverse outcomes in a population-based prospective cohort observational study of alaska native/american indian persons with chronic hcv infection. | 2017 | 27765729 |
| the changing epidemiology and aetiology of hepatocellular carcinoma from 1969 through 2013 in alaska native people. | alaska native people have an increased rate of hepatocellular carcinoma compared to the united states population. viral hepatitis is a risk factor for malignancy and the leading cause of hepatocellular carcinoma in alaska. with the introduction of hepatitis b immunization in 1982, as well as the emergence of hepatitis c virus in this population, the epidemiology and aetiology of hepatocellular carcinoma in alaska have changed. | 2016 | 27224493 |
| identification and clinical management of persons with chronic hepatitis c virus infection - cherokee nation, 2012-2015. | an estimated 3.5 million persons in the united states are living with hepatitis c virus (hcv) infection, resulting in approximately 20,000 deaths each year, primarily from cirrhosis or hepatocellular carcinoma (1,2). american indian/alaska native (ai/an) populations have the highest incidence of acute hcv infection among all u.s. racial/ethnic groups and are at greater risk for hcv-related mortality compared with the general population (3). in 2013, new antiviral drugs became available that make ... | 2016 | 27172175 |
| birth cohort testing for hepatitis c virus - indian health service 2012-2015. | hepatitis c virus (hcv) infection is a substantial and largely unrecognized public health problem. an estimated 3.5 million persons in the united states are currently living with hcv infection, at least half of whom are unaware of their infection (1-3). persons born during 1945-1965 (the "baby boomer" birth cohort) have a sixfold higher prevalence (2.6%) than adults of other ages, and represent 81% of all persons chronically infected with hcv (4). therefore, in addition to recommending testing f ... | 2016 | 27171026 |
| results of interferon-based treatments in alaska native and american indian population with chronic hepatitis c. | there have been few reports of hepatitis c virus (hcv) treatment results with interferon-based regimens in indigenous populations. | 2016 | 27029671 |
| the prevalence and presumed etiology of elevated aminotransferase levels in a pacific northwest tribal community. | american indians and alaska natives (ai/ans) die from chronic liver disease at high rates, but little data exist on the etiology of liver disease in ai/ans. adult participants from a tribal health clinic in the pacific northwest completed an alcohol consumption survey and underwent laboratory testing, and anthropometric measurements. participants with abnormal serum alanine aminotransferase (alt) levels, positive hepatitis b surface antigen, or hepatitis c antibody were invited for follow-up vis ... | 2015 | 26320926 |
| challenges of hepatitis c treatment in native americans in two north dakota medical facilities. | the prevalence of chronic liver disease (cld) in the aboriginal north american population is disproportionately higher than that of the non-indigenous population. hepatitis c virus (hcv) is the second leading cause of cld in american indians or alaska natives (aians). this study described the experience of two teaching community medical centers in north dakota in treating hcv infection among aians and compared treatment outcomes to a cohort of caucasian patients. | 2014 | 25238693 |
| treatment eligibility in alaska native and american indian persons with hepatitis c virus infection. | treatment with pegylated interferon and ribavirin may prevent progression of liver disease among patients with chronic hepatitis c virus infection (hcv). treatment initiation is based on published clinical eligibility criteria, patients' willingness to undergo treatment and likelihood of success. we examined treatment eligibility in a cohort of alaska native and american indian persons with chronic hcv infection. | 2012 | 22564468 |
| disparities in liver cancer occurrence in the united states by race/ethnicity and state. | liver cancer is highly fatal, and death rates in the united states are increasing faster than for any other cancer, having doubled since the mid-1980s. in 2017, it is estimated that the disease will account for about 41,000 new cancer cases and 29,000 cancer deaths in the united states. in this article, data from the surveillance, epidemiology, and end results (seer) program and the national center for health statistics are used to provide an overview of liver cancer incidence, mortality, and su ... | 2017 | 28586094 |
| risk of end-stage liver disease, hepatocellular carcinoma, and liver-related death by fibrosis stage in the hepatitis c alaska cohort. | long-term prospective studies of the outcomes associated with hepatitis c virus (hcv) infection are rare and critical for assessing the potential impact of hcv treatment. using liver biopsy as a starting point, we analyzed the development of end-stage liver disease (esld), hepatocellular carcinoma (hcc), and liver-related death (lrd) according to fibrosis stage among a cohort of american indian/alaska native persons in alaska. persons were classified as having no/mild (ishak = 0,1), moderate (is ... | 2017 | 28195349 |
| implementation of national hiv screening recommendations in the indian health service. | the indian health service (ihs), a federal agency, provides direct patient care to an estimated 1.9 million american indian/alaska native patients across a large and decentralized network of health facilities. the ihs sought to implement hiv screening of adults and adolescents per national recommendations. the ihs facilities received technical support such as electronic clinical reminders (ecrs) and sample hiv-testing policies. | 2016 | 25656861 |
| chronic liver disease mortality in the united states, 1990-1998. | in 1998, chronic liver disease (cld) was the tenth leading cause of death in the u.s. alcohol and hepatitis c are thought to be important etiologies. however, traditional methods for calculating cld mortality rates from death certificates may underestimate hepatitis c-related cld mortality. we studied patterns of cld deaths reported from 1990 through 1998, using an expanded definition that included death certificates where cld, viral hepatitis, or cld-related sequelae were reported as the underl ... | 2004 | 14768001 |