factors associated with encephalopathy in patients with salmonella enterica serotype typhi bacteremia presenting to a diarrheal hospital in dhaka, characterize clinical correlates of typhoid fever-associated encephalopathy, we performed a retrospective chart review of patients with salmonella enterica serotype typhi bacteremia who were hospitalized at the international centre for diarrhoeal disease research, bangladesh, from february of 2009 to june of 2011. of 207 patients bacteremic with salmonella typhi who were ≥ 5 years of age, we identified 43 (21%) patients with encephalopathy. univariate analysis revealed that patients with ence ...201222492156
salmonella enterica serovar typhi-specific immunoglobulin a antibody responses in plasma and antibody in lymphocyte supernatant specimens in bangladeshi patients with suspected typhoid fever.many currently available diagnostic tests for typhoid fever lack sensitivity and/or specificity, especially in areas of the world where the disease is endemic. in order to identify a diagnostic test that better correlates with typhoid fever, we evaluated immune responses to salmonella enterica serovar typhi (serovar typhi) in individuals with suspected typhoid fever in dhaka, bangladesh. we enrolled 112 individuals with suspected typhoid fever, cultured day 0 blood for serovar typhi organisms, a ...200919741090
bacteremic typhoid fever in children in an urban slum, bangladesh.we confirmed a bacteremic typhoid fever incidence of 3.9 episodes/1,000 person-years during fever surveillance in a dhaka urban slum. the relative risk for preschool children compared with older persons was 8.9. our regression model showed that these children were clinically ill, which suggests a role for preschool immunization.200515752457
molecular typing of salmonella typhi strains from dhaka (bangladesh) and development of dna probes identifying plasmid-encoded multidrug-resistant isolates.seventy-eight salmonella typhi strains isolated in 1994 and 1995 from patients living in dhaka, bangladesh, were subjected to phage typing, ribotyping, is200 fingerprinting, and pcr fingerprinting. the collection displayed a high degree of genetic homogeneity, because restricted numbers of phage types and dna fingerprints were observed. a significant number of the s. typhi strains (67%) were demonstrated to be multiple drug resistant (mdr). the vast majority of the mdr strains were resistant to ...19968735083
morbidity and mortality in a diarrhoeal diseases hospital in bangladesh.records of all patients who were admitted to or who died in dhaka hospital of the international centre for diarrhoeal disease research, bangladesh (icddr,b) between july 1980 and 30th june 1981 were reviewed to identify epidemiological characters associated with in-hospital diarrhoeal diseases-related deaths. information on aetiological agents, age, sex, major complications, nutritional status and level of dehydration were analysed. over the one-year period, 3251 patients were admitted to the me ...19863603613
burden of typhoid and paratyphoid fever in a densely populated urban community, dhaka, bangladesh.we conducted blood culture surveillance to estimate the incidence of typhoid and paratyphoid fever among urban slum residents in dhaka, bangladesh.201020236850
molecular basis of resistance displayed by highly ciprofloxacin-resistant salmonella enterica serovar typhi in bangladesh.highly ciprofloxacin-resistant (mic, 512 microg/ml) strains of salmonella enterica serovar typhi were isolated from the blood of typhoid patients in dhaka, bangladesh. the strains were indistinguishable by their antibiograms, biotypes, and variable-number tandem repeat types and had matching point mutations at positions 83 and 87 of the gyra gene. the isolation of these strains in an area of high endemicity indicates the need for continuous surveillance of antibiotic resistance of s. enterica se ...200617021117
multidrug-resistant salmonella enterica serovar typhi isolates with high-level resistance to ciprofloxacin in dhaka, bangladesh. 200617005846
interferon-╬│ and proliferation responses to salmonella enterica serotype typhi proteins in patients with s. typhi bacteremia in dhaka, bangladesh.salmonella enterica serotype typhi is a human-restricted intracellular pathogen and the cause of typhoid fever. cellular immune responses are required to control and clear salmonella infection. despite this, there are limited data on cellular immune responses in humans infected with wild type s. typhi.201121666798
emergence of multidrug-resistant salmonella enterica serotype typhi with decreased ciprofloxacin susceptibility in bangladesh.during 1989-2002, we studied the antimicrobial resistance of 3928 blood culture isolates of salmonella enterica serotype typhi (s. typhi) in dhaka, bangladesh. overall 32% (1270) of the strains were multidrug-resistant (mdr, resistant to chloramphenicol, ampicillin and trimethoprim-sulphamethoxazole); first detected in 1990 (rate of 8%), increased in 1994 (44%), declined in 1996 (22%, p<0.01 compared to 1994) and re-emerged in 2001 (36%) and 2002 (42%, p<0.01 compared to 1996). an increased mic ...200616490150
immunoproteomic analysis of antibody in lymphocyte supernatant in patients with typhoid fever in bangladesh.we have previously shown that an assay based on detection of anti-salmonella enterica serotype typhi antibodies in supernatant of lymphocytes harvested from patients presenting with typhoid fever (antibody in lymphocyte supernatant [als] assay) can identify 100% of patients with blood culture-confirmed typhoid fever in bangladesh. in order to define immunodominant proteins within the s. typhi membrane preparation used as antigen in these prior studies and to identify potential biomarkers unique ...201424371257
salmonella enterica serovar typhi strain producing extended-spectrum β-lactamases in dhaka, bangladesh. 201222442289
typhoid fever in bangladesh: implications for vaccination describe the age-specific distribution of typhoid fever including the degree of salmonella typhi bacteremia among patients evaluated at a large private diagnostic center in bangladesh, a highly endemic area.200111368111
decline in epidemic of multidrug resistant salmonella typhi is not associated with increased incidence of antibiotic-susceptible strain in bangladesh.since 1987, multidrug resistant (mdr) strains of salmonella typhi, resistant simultaneously to ampicillin, chloramphenicol and trimethoprim-sulfamethoxazole, have caused epidemics of severe typhoid fever in asia and africa. a retrospective analysis of blood culture results (1989-96) in a diarrhoea treatment centre in dhaka, bangladesh detected mdr strains in 0.3% (8 of 2793) of samples in 1990. the isolation rate peaked to 3.2% (240 of 7501) in 1994 (p < 0.01) and decreased to 1.8% (165 of 9348) ...200212211593
emergence of multidrug-resistant salmonella gloucester and salmonella typhimurium in bangladesh.infections due to non-typhoid salmonella, resistant to antibiotics, have recently emerged as an important health problem worldwide. antibiotic resistance was studied by the disc-diffusion method among 3,876 (2.78%) non-typhoid salmonella isolates cultured from 139,279 faecal samples in a diarrhoea treatment centre in dhaka, bangladesh, during 1989-1996. of 499 salmonellae isolated in 1989, serogroup c (1.12%) was the most common, followed by salmonella typhi (0.72%) and serogroup b (0.71%). isol ...200111761773
salmonella typhi and plasmodium falciparum co-infection in a 12-year old girl with haemoglobin e trait from a non-malarious area in bangladesh.a 12-year old girl from uttar badda, dhaka, bangladesh, was admitted to the dhaka hospital of icddr,b, with a 23-day history of fever and diarrhoea. after admission, she was treated for culture-proven salmonella typhi-associated infection and was discovered to be heterozygous for haemoglobin e. despite treatment with appropriate antibiotics, the patient's condition did not improve, prompting further investigation, which revealed malaria due to plasmodium falciparum. dhaka is considered a malaria ...201020941905
a low-cost approach to measure the burden of vaccine preventable diseases in urban areas.we piloted a low-cost approach to measure the disease burden of streptococcus pneumoniae, hib and salmonella typhi by leveraging the existing infrastructure of high performing microbiology laboratories at two large paediatric hospitals in dhaka bangladesh, and assessing the hospital utilization of the catchment population of these hospitals for different syndromes. s. typhi was the most common bacterium identified in culture and accounted for an estimated 211 hospitalizations per 100,000 childre ...201020653079
enteric fever in patients admitted to a diarrhoeal disease hospital in bangladesh.the hospital records of 62 patients with blood culture-proven enteric fever admitted to the dacca hospital of the international centre for diarrhoeal disease research, bangladesh, over a one-year period were reviewed. older children and young adults had the highest age-specific rates of disease. the clinical, epidemiological and laboratory features of patients with enteric fever were compared with similar information from patients in hospital for cholera and shigellosis. patients with enteric fe ...19836636284
decrease of antibiotic resistance in salmonella typhi isolated from patients attending hospitals of dhaka city over a 3 year period.salmonella typhi is an important cause of enteric fever in bangladesh. resistance to commonly used antibiotics like cotrimoxazole and ampicillin has led to the introduction of third generation cephalosporins and fluoroquinolones for the treatment of enteric fever. prescription patterns for enteric fevers and for other infections have been changing and so we looked at the antibiotic resistance of s. typhi isolated from patients in and around dhaka city from 1996-1998. the study showed a gradual c ...200011091044
salmonella-a new threat to admitted 582 neonates with suspected septicaemia were studied in microbiology department of dhaka medical college, dhaka, bangladesh. samples being taken from neonatal unit of dhaka medical college hospital and a neonatal private hospital in one year (january to december 2004). blood culture was done by lytic-centrifugation method. the isolated organisms were identified using standard laboratory procedures. among 582 sick neonates 59(10.14%) were culture positive and the predominant org ...200717917624
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