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expression studies of delta-globin gene alleles associated with reduced hemoglobin a2 levels in greek cypriots.we previously identified five delta-globin gene alleles associated with reduced hemoglobin (hb) a2 (trifillis, p., ioannou, p., schwartz, e., and surrey, s. (1991) blood 78, 3298-3305). we have now evaluated functional consequences of the changes after expression in cos-1 cells to monitor effects on rna splicing. in addition, variant hb a2 tetramers were expressed in yeast to assess effects of amino acid changes on oxygen binding and stability to heat and mechanical agitation. the g --> t change ...19968900178
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