Publications

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[tetravaccine--new fundamental approach to prevention of influenza pandemic].according to opinion of who's experts, development and use of tetravaccine, which contains both interdemic and pandemic (h5n1) serotypes of influenza viruses, is one of the most promising approaches to control possible influenza pandemic. results of recently obtained data from clinical trials allowed experts from who to make a conclusion that protective immunity against avian influenza virus can be achieved after 2-doses immunization, when the immune system will be primed to hemagglutinin after ...200717882832
[molecular characteristic of influenza virus a h5n1 strains isolated from poultry in kurgan region in 2005].during the latter half of 2005 a widespread outbreak caused by influenza highly pathogenic h5n1 virus among wild and domestic birds occurred in russia. as pathogenicity level is a polygenic feature and majority of individual genes of influenza a viruses contribute to pathogenicity of influenza viruses to birds, animals and humans. nucleotide sequencing of the entire genome of influenza h5n1 virus isolates obtained in kurgan region (western siberia) was performed. structure of viral proteins was ...200818389623
[infection of pigs with influenza a/h4 and a/h5 viruses isolated from wild birds on the territory of russia].pigs were intranasally infected with avian influenza a/h5 (h5n1, h5n3) and a/h4 (h4n6, h4n8) viruses in mono- and coinfection. infection with both apathogenic and pathogenic strains caused no clinical manifestations. a virus and/or fragments of its genome retained in nasopharyngeal fluid as long as 6-8 days after infection. during monoinfection, the structure of the hemagglutinin (ha) receptor site of isolates from the pigs infected with a/h5n1 strains (a/chicken/kurgan/3/2005, a/duck/russia/535 ...200819172904
[triazavirin prophylactic efficacy against influenza virus a (h5n1)].the experimental study of the prophylactic efficacy of triazaverin against the experimental form of the influenza virus a (h5n1) on albino mice intranasally infected with the influenza virus a/chicken/kurgan/russia/02/05 vs. the reference drugs tamiflu, remantadin and arbidol showed that in doses of 1 to 100 mg/kg it was efficient in the animal protection from death. the drug was also efficient in the urgent prophylaxis. triazaverin effectively inhibited the influenza a virus multiplication in t ...201021400750
[therapeutic efficacy of triazavirin, a novel russian chemotherapeutic, against influenza virus a (h5n1)].therapeutic activity of triazavirin against experimental influenza a was studied on albino mice intranazally infected with influenza virus a/chicken/kurgan/russia/02/05 (h5n1) vs. reference drugs (oseltamivir, remantadin and arbidol). the study showed that in a therapeutic dose of 1 mg/kg triazavirin was efficient in protection of the animals from death. its protective therapeutic efficacy (36.7+/-1.7%) was close to that of oseltamivir (50.0+/-0.0%), comparable with that of remantadin (38.3+/-1. ...201121780665
antiviral activity of polyporoid mushrooms (higher basidiomycetes) from altai mountains (russia).antiviral activity against type a influenza virus of birds a/chicken/kurgan/05/2005 (h5n1) and humans a/aichi/2/68 (h3n2) was investigated for aqueous extracts from mycelium of 11 basidial fungi species collected in the altai mountains (altai republic, russia). the most perspective strains for producing antiviral medicines are studied strains daedaleopsis confragosa, datronia mollis, ischnoderma benzoinum, trametes gibbosa, t. versicolor, laricifomes officinalis, and lenzites betulina.201222339706
infection of chickens caused by avian influenza virus a/h5n1 delivered by aerosol and other routes.this study presents results of the study of infectivity of avian influenza virus (aiv) a subtype h5n1 strains isolated from agricultural birds across the territory of the russian federation and cis countries. the results of the susceptibility of chickens to the aiv isolates delivered by the aerosol route and the dissemination of the virus in the organs of infected birds are presented. as was observed, the sensitivity of birds to aiv by the aerosol route of infection is 30 times higher than by in ...201322494627
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