Publications

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impaired immune function and identification of polybrominated biphenyls (pbb) in blood compartments of exposed michigan dairy farmers and chemical workers.in 1973 pbb's were accidentally mixed into animal feed, resulting in marked toxic effects. meat and dairy products were widely consumed in michigan. to determine the impact of pbb's, 55 exposed michigan farm residents, 11 michigan chemical workers and 46 non-exposed wisconsin farmers were examined. abnormalities included decreased number of t-lymphocytes with concomitant increase of lymphocytes with no detectable surface markers, "null cells", and altered lymphocyte function. data obtained from ...1979232874
symposium on pertussis immunization, in honor of dr. pearl l. kendrick in her eightietn year: historical notes on pertussis immunization. 19714329892
rabies surveillance in the united states during 1999.during 1999, 49 states, the district of columbia, and puerto rico reported 7,067 cases of rabies in nonhuman animals to the centers for disease control and prevention, a decrease of 11.2% from 7,961 cases in nonhuman animals and 1 case in a human being reported in 1998. more than 91% (6,466 cases) were in wild animals, whereas 8.5% (601 cases) were in domestic species (compared with 92.4% in wild animals and 7.6% in domestic species in 1998). no cases of rabies were reported in human beings in 1 ...200011132881
occupation, pesticide exposure and risk of multiple myeloma.this population-based case-control study examined the relationship between occupation, living or working on a farm, pesticide exposure, and the risk of multiple myeloma.200415250650
carriage of clostridium difficile and other enteric pathogens among a 4-h avocational cohort.clostridium difficile (cd), salmonella, campylobacter and enterohemorrhagic escherichia coli (ehec) are major causes of morbidity in a variety of enteric diseases in humans and animals, but subclinical carriage in both is probably more common than are clinical cases. little is known regarding the prevalence of these pathogens in animals raised for exhibit at michigan county fairs or the frequency with which michigan citizens raising these animals may have been subclinically colonized. to address ...201120529211
characterization of vancomycin-resistant enterococcus faecium isolated from swine in three michigan counties.vancomycin-resistant enterococci are a major cause of nosocomial infections but are rarely found in humans in the community and have not been identified in food animals in the united states. we evaluated a total of 360 fecal specimens from humans and their animals being raised for exhibit at three county fairs in michigan. fecal samples from 158 humans, 55 swine, 50 cattle, 25 horses, 57 sheep, 14 goats, and 1 llama were obtained and plated onto enterococcosel agar containing 16 μg/ml of vancomy ...201020739498
maintaining the standard: a quality assurance study for new equipment in the michigan ecmo program.activated clotting time (act) ranges are targeted to minimize both bleeding and clotting complications during anticoagulation for extracorporeal life support (ecls) therapy. a change in the equipment used to measure act at the bedside prompted a laboratory-based method comparison study in an animal model to compare act results from two hemochron machines. a retrospective, observational cohort study was undertaken to compare bleeding and clotting complications for both "eras" of hemochron machine ...200717885327
lymphocyte function of michigan dairy farmers exposed to polybrominated biphenyls.michigan dairy farm residents ate farm products containing polybrominated biphenyls (pbb's) after the accidential contamination of animal feed with the chemical in that state in 1973. the circulating blood lymphocytes of these residents show significant changes. abnormalities include decreases in the numbers and percentages of peripheral blood lymphocytes that form rosettes with either sheep erythrocytes alone or with sheep erythrocytes sensitized with antibody and complement, increases in lymph ...1978204005
observations on besnoitiosis in virginia opossum (didelphis virginiana) from michigan, usa.besnoitia tissue cysts were found in five naturally-infected adult opossums (didelphis virginiana) from michigan. details of the microscopy, histopathology, ultra-structure, and genetic features of the cysts were studied to identify their species-specific traits. the materials were differentiated phenotypically from cysts of other besnoitia spp. by difference in size, pattern of tissue distribution, morphology of pellicle and nucleus, number of micronemes and rhoptries, amount of lipids and amyl ...200717580564
a recombinant antigen from the heartwater agent (cowdria ruminatium) reactive with antibodies in some southeastern united states white-tailed deer (odocoileus virginianus), but not cattle, sera.recombinant baculovirus techniques were used to express the 260 amino acid carboxyterminal portion of the 32 kilodalton (kda) major antigenic protein (map 1) of cowdria ruminantium, the heartwater agent, as a fusion protein. the recombinant map 1 was fused to an aminoterminal independently antigenic octapeptide sequence (flag peptide). recombinant map 1 was used as an immunoblotting antigen to evaluate numerous reference antisera against organisms of the tribe ehrlichieae. monoclonal and polyclo ...19968827667
frequency of sarcocystis spp in detroit, metropolitan area, michigan.a survey of sarcocystis spp in feral animals and in domesticated animals slaughtered in detroit, mi, was undertaken during a 6-month period, april to september, 1973, using histologic and digestion diagnostic techniques. results indicated 75.3% of 789 sheep and 10.8% of 306 lambs were infected. infection in young and adult sheep was low in april (0% of 78 lambs and 6.7% of 62 adult sheep), but increased in july (24% of 90 lambs and 94.1% of 201 adult sheep). high frequency of sarcocystis in summ ...1975803806
environmental considerations for the disposal of pbb-contaminated animals and wastes.accidental contamination of livestock feed in 1973 by polybrominated biphenyls (pbb) led to the destruction of over 30,000 animals in michigan. animal carcasses of mostly dairy cattle along with some beef cattle, hogs, sheep and rabbits destroyed under the federal food and drug administration guidelines were disposed on the land at an environmentally safe site in kalkaska county, michigan. the geology and hydrology of the disposal site on state-owned land is considered favorable for the disposal ...1978209986
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