Publications

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two new flavones from calliandra californica.two new flavones were isolated from the medicinal plant calliandra californica, 7,2',4',5'-tetramethoxyflavone [1] and 5-hydroxy-7,2',4',5'-tetramethoxyflavone [2]. the structures were determined from spectral evidence and both compounds were synthesized. compound 2 exhibited antimicrobial activity for two test bacterial strains.19947798967
the epidemiology of candidemia in two united states cities: results of a population-based active surveillance.we conducted prospective, active population-based surveillance for candidemia (defined as any candida species isolated from blood) in atlanta and san francisco (total population, 5.34 million) during 1992-1993. the average annual incidence of candidemia at both sites was 8 per 100,000 population. the highest incidence (75 per 100,000) occurred among infants </=1 year old. in 19% of patients, candidemia developed prior to or on the day of admission. underlying medical conditions included cancer ( ...199910524958
fungal culture findings in cyclic vulvitis.to estimate the prevalence of fungal infection in cyclic vulvitis.200010908782
daryamides a-c, weakly cytotoxic polyketides from a marine-derived actinomycete of the genus streptomyces strain cnq-085.in the course of our continuing search for new antitumor-antibiotics from marine-derived actinomycete bacteria, four new cytotoxic compounds, designated as daryamides a (1), b (2), and c (3) and (2e,4e)-7-methylocta-2,4-dienoic acid amide (4), were isolated from the culture broth of a marine-derived streptomyces strain cnq-085. the structures of these new compounds were assigned by detailed interpretation of spectroscopic data. the relative configuration of 1 was determined by comprehensive nmr ...200617190455
bacteremia on an obstetric-gynecologic service.in a one-year evaluation of the obstetric-gynecologic services of the los angeles county university of southern california medical center, bacteremia was confirmed on 144 occasions in 139 patients. this represented an over-all incidence of 7/1,000 admissions with gram-negative bacteremia observed in 3.1/1,000 admissions. there were four deaths in this series. the most frequently recovered aerobes were escherichia coli, enterococci, and beta hemolytic streptococci, not group a or d, while the mos ...19751090168
alfalfa hay induced primary photosensitization in horses.photosensitization, also known as photodermatitis, occurs when phototoxic or photoactive substances accumulate in the skin and interact with sunlight to result in an often severe, crusting, itching or painful dermatitis in unpigmented and/or lightly haired areas of the skin. primary photosensitization, caused by direct ingestion of photosensitizing agents, has been reported anecdotally in horses after ingestion of alfalfa hay. between 2004 and 2014, several large outbreaks of primary photosensit ...201627040919
evaluation of enzyme-linked immunosorbent assays for detecting circulating antibodies to candida albicans.published studies indicate that candida albicans antibody assays utilizing cytoplasmic antigens offer greater utility for identifying cases of systemic candidiasis when compared with assays utilizing cell wall components. we assessed the performance characteristics of a commercially available system that utilizes cytoplasmic antigens to measure c. albicans igg, igm, and iga (candida detect elisa reagents). intra-assay variation was < or =5%, inter-assay variation was < or =10%, and good linearit ...200818623122
nosocomial outbreak of candida albicans sternal wound infections following cardiac surgery traced to a scrub nurse.from august 1988 through october 1989, 15 patients at 1 hospital developed candida albicans sternal wound infections after cardiac surgery. an investigation found that case-patients were more likely than cardiac surgery patients without sternal wound infections to have surgeries lasting > 165 min (11/15 vs. 20/45; odds ratio [or], 5.0; 95% confidence interval [ci], 1.5-16.3) or exposure to first scrub nurse a (15/15 vs. 22/45; or, infinity; 95% ci, 2.5, infinity). molecular typing of 5 case-pati ...19957658076
the pathology of an epizootic of acquired immunodeficiency in rhesus macaques.a syndrome of acquired immunodeficiency within a group of outdoor-housed rhesus macaques (macaca mulatta) with unusually high mortality has been identified at the california primate research center. the cause of death for most of the affected animals included septicemia and/or chronic diarrhea with wasting, often complicated by other problems. in many cases, multiple or unusual infectious agents were isolated or recognized, including cytomegalovirus, cryptosporidium spp., and candida albicans. s ...19846691418
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