Publications

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frequency, intensity, species, and strains of oral candida vary as a function of host age.while the age of the host has been suggested as a determining factor in yeast carriage, no studies in which the genetic relatedness of isolates has been assessed in combination with the frequency and intensity of carriage as a function of host age have been performed in a single geographical locale and over a short time window. therefore, by using a simple plating protocol to determine the frequency and intensity of carriage, sugar assimilation patterns to determine species, and southern blot hy ...19968862593
case-control study of vulvar vestibulitis risk associated with genital infections.to evaluate the risk of vulvar vestibulitis syndrome (vvs) associated with genital infections in a case-control study.200212648313
candidemia surveillance in iowa: emergence of echinocandin resistance.we performed prospective surveillance for candidemia at 14 iowa hospitals in 2011-2012. a total of 163 episodes were analyzed. candida albicans (n = 69 [42%]) and candida glabrata (n = 58 [36%]) were the most common species. antifungal resistance was uncommon; 9% of c. glabrata were fluconazole resistant, and 5% (3 isolates) were intermediate or resistant to 1 or more of the echinocandins. molecular analyses of the fks1 and fks2 hotspots of the c. glabrata revealed no mutations except in 2 of th ...201424666704
epidemiology of candidemia: 3-year results from the emerging infections and the epidemiology of iowa organisms study.bloodstream infections due to candida species cause significant morbidity and mortality. surveillance for candidemia is necessary to detect trends in species distribution and antifungal resistance. we performed prospective surveillance for candidemia at 16 hospitals in the state of iowa from 1 july 1998 through 30 june 2001. using u.s. census bureau and iowa hospital association data to estimate a population denominator, we calculated the annual incidence of candidemia in iowa to be 6.0 per 100, ...200211923348
trends in antifungal use and epidemiology of nosocomial yeast infections in a university hospital.this report describes both the trends in antifungal use and the epidemiology of nosocomial yeast infections at the university of iowa hospitals and clinics between fiscal year (fy) 1987-1988 and fy 1993-1994. data were gathered retrospectively from patients' medical records and from computerized databases maintained by the pharmacy, the program of hospital epidemiology, and the medical records department. after fluconazole was introduced, use of ketoconazole decreased dramatically but adjusted u ...19999986807
computer-assisted methods for assessing strain relatedness in candida albicans by fingerprinting with the moderately repetitive sequence ca3.when used to probe ecori-digested candida albicans dna, the moderately repetitive sequence ca3 generated a southern blot hybridization pattern which included 15 to 25 bands, depending upon the strain. the pattern was stable through 400 generations in each of three independent strains but variable between most of 46 unrelated tester strains, making it a very effective probe for discrimination between strains. computer-assisted methods (dendron) were developed for storage of ca3 patterns in data f ...19902199493
antifungal susceptibilities of candida species causing vulvovaginitis and epidemiology of recurrent cases.there are limited data regarding the antifungal susceptibility of yeast causing vulvovaginal candidiasis, since cultures are rarely performed. susceptibility testing was performed on vaginal yeast isolates collected from january 1998 to march 2001 from 429 patients with suspected vulvovaginal candidiasis. the charts of 84 patients with multiple positive cultures were reviewed. the 593 yeast isolates were candida albicans (n = 420), candida glabrata (n = 112), candida parapsilosis (n = 30), candi ...200515872235
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